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Neuro-Oncology Advances logoLink to Neuro-Oncology Advances
. 2025 Nov 7;7(Suppl 5):vdaf213.100. doi: 10.1093/noajnl/vdaf213.100

SBPS-10 POSTOPERATIVE EVOLUTION OF PITUITARY ADENOMAS RETAINED BY TRANSSPHENOIDAL ENDONASAL ENDOSCOPIC APPROACH : IVORIAN EXPERIENCE OF 150 CASES

Landry Teti 1,2, Landry Konan 3, Soress Dongo 4, Konan Serges Yao 5, Bernard Fionko 6, Traore Aboubakar 7, Ange Yao 8, Désirée Kofi 9, Mbiakeu Jorel 10, Dzidoula Lawson 11, Louis Derou 12, Valentin Tokpa 13, Aderehime Haidara 14, Jacko Abodo 15
PMCID: PMC12690752

Abstract

Introduction

Transsphenoidal endonasal endoscopic surgery has established itself as the preferred approach for the treatment of pituitary adenomas. Although this minimally invasive approach offers excellent results in terms of tumor resection and reduced morbidity, the quality of postoperative medical care remains a determining factor in functional prognosis.

Objective

To analyze the modalities of post-operative medical management and evaluation of the clinical, endocrine and radiological evolution of patients presenting with a pituitary adenoma by transsphenoidal endonasal endoscopic approach.

Methodology

This is a retrospective, single-center study involving 150 patients selected between 2015 and 2022. Functional adenomas represented 58% of cases, with a predominance of prolactinomas (33%), followed by corticotropes (17%) and somatotropes (5%). Nonfunctional adenomas constituted 42% of cases. The analysis focused on tumor characteristics, postoperative complications, hormonal replacement management and medium-term results.

Results

Hormone replacement was initiated in 65% of patients. Transient diabetes insipidus occurred in 12% of cases, while cerebrospinal fluid (CSF) leak was observed in 6% of patients. A visual disturbance was noted in 82% of the cases concerned. Complete endocrine recovery was achieved in 22% of patients. The five-year radiological recurrence rate is 15%, mainly observed in invasive or partially resected adenomas.

Conclusion

Postoperative management of pituitary adenomas requires a multidisciplinary approach, with rigorous endocrine monitoring. Long-term evaluation shows an overall favorable evolution, although the need for hormone replacement therapy remains frequent. Earlier anticipation of post-operative endocrine disorders helps improve patients’ quality of life.


Articles from Neuro-Oncology Advances are provided here courtesy of Oxford University Press

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