Fig. 2.

Manhathan plots of the association between genome-wide DNA methylation and phthalate and DINCH metabolite levels, by exposure period. Each dot is the association of the DNA methylation levels at one CpG with the levels of one of the phthalate or DINCH metabolites measured at 19w (A), at 35w (B), and in whole pregnancy (C). The x-axis represents the position of the CpGs and the y-axis the −log10 p value of the association. The horizontal dashed lines are the suggestive (1E-05p value < 1E-05) and Bonferroni (p value < 1E-7) multiple-testing thresholds. Associations surviving Bonferroni correction are coloured according to the legend. For CpGs annotated to a gene, the gene is shown, for the rest, the CpG ID is shown.