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. 1966 Dec;101(3):698–706. doi: 10.1042/bj1010698

Metabolism of the herbicide 2,6-dichlorobenzonitrile in rabbits and rats

J G Wit 1, H Van Genderen 1
PMCID: PMC1270175  PMID: 16742447

Abstract

1. The metabolism of 2,6-dichlorobenzonitrile was studied in rabbits and rats. Oral administration caused an increased urinary excretion of glucuronides and ethereal sulphates. There was also an indication of mercapturic acid formation. 2,6-Dichloro-3-hydroxybenzonitrile and its 4-hydroxy analogue were identified as metabolites in the urine. A small amount of the unchanged substance was recovered from the faeces. 2. By using 2,6-dichlorobenzo[14C]nitrile the phenolic metabolites were determined quantitatively and some other possible metabolic routes were excluded. 3. Incubation of 2,6-dichlorobenzonitrile with enzyme preparations (papain and high-speed supernatant of rat-liver homogenate plus glutathione) gave no indications for a reaction with thiol compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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