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. 1967 May;103(2):472–479. doi: 10.1042/bj1030472

The formation of lithocholic acid, chenodeoxycholic acid and α- and β-muricholic acids from cholesterol incubated with rat-liver mitochondria

K A Mitropoulos 1, N B Myant 1
PMCID: PMC1270430  PMID: 6047622

Abstract

1. When rat-liver mitochondria were incubated with [4-14C]cholesterol in the presence of a soluble supernatant fraction, various steroids more polar than cholesterol were formed. These included 3β-hydroxycholest-5-en-26-oic acid, 3β-hydroxychol-5-enoic acid, lithocholic acid, chenodeoxycholic acid and α- and β-muricholic acids. 2. All the radioactive C24 bile acids recovered were in conjugated form, probably as taurine conjugates. 3. The formation of 3β-hydroxychol-5-enoic acid from cholesterol shows that liver mitochondria are capable of carrying out the oxidative removal of the isopropyl unit of the side chain before any modification has occurred in the ring system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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