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. 1967 Aug;104(2):435–440. doi: 10.1042/bj1040435

Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine

Valda M Craddock 1, P N Magee 1
PMCID: PMC1270604  PMID: 6048785

Abstract

1. Evidence is presented for the excretion of 7-methylguanine in normal rat urine at a rate of approx. 65μg./day. Experiments with animals in which the nucleic acids had been prelabelled by treatment of the neonatal rats with [14C]-formate gave evidence that the methylated base originated in the nucleic acids of the rat. 2. Injection of [14C]dimethylnitrosamine leads to an increased excretion of 7-methylguanine, and the base becomes labelled in the methyl group. The disappearance of labelled 7-methylguanine formed in nucleic acids of rats treated with the carcinogen therefore does not take place by an N-demethylation reaction, but by liberation of the intact methylated base.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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