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. 1967 Aug;104(2):616–626. doi: 10.1042/bj1040616

Cyanogen bromide cleavage and partial sequence of the heavy chain of a pathological immunoglobulin G

P J Piggot 1, E M Press 1
PMCID: PMC1270628  PMID: 4167412

Abstract

The heavy chain of a pathological immunoglobulin G (Daw) of type L, subclass γ2b (We) and Gm(a+)(f−), has been cleaved with cyanogen bromide. The five fragments resulting from the cleavage have been isolated and analysed. The papain-digest fragments, Fab and Fc, have also been cleaved with cyanogen bromide and the products analysed and compared with those from the heavy chain. The order of the five fragments in the heavy chain has been established and the location of some of the inter-chain and inter-fragment disulphide bonds has been determined. The sequence of the N-terminal fragment consisting of 34 residues is reported.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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