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. 1980 Oct;133(4):279–288.

Remission-Induction Regimens in Acute Nonlymphocytic Leukemia

Donald C Brennan 1,2, Jerry P Lewis 1,2
PMCID: PMC1272302  PMID: 7347042

Abstract

A sequential study was carried out involving 40 adults with acute nonlymphocytic leukemia (ANLL). The first 20 patients were treated with cytarabine (Ara-C) and 6-thioguanine (6-TG), the second 20 with a regimen that added a three-day course of daunomycin (DNM) to the Ara-C and 6-TG therapy. With both groups well matched for age, patients in the DNM-treated group had a higher complete remission (CR) rate but failed to survive longer than those in the Ara-C and 6-TG treatment group. In a comprehensive literature review of various treatments for adult ANLL, a higher CR rate but not significantly better survival for patients initially treated with DNM-combined regimens was found. Our analysis of cases and literature review suggest that while DNM is a very active drug, its use in the initial treatment of adult ANLL has not produced a significant improvement in overall survival or in survival of those brought into complete remission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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