Abstract
The estrogen component in oral contraceptives is generally thought to increase the risk of stroke in users as compared with controls. If this were true, an increased risk for stroke also should be seen among postmenopausal women using estrogens as compared with nonusers. To test this hypothesis, the charts of 198 postmenopausal patients who had had strokes were compared with those of 396 controls for estrogen use and for the associated risk factors of diabetes, hypertension and coronary artery disease. The difference between estrogen use in the study population versus controls proved not significant, and the use of estrogens did not significantly influence the distribution of the above risk factors. We concluded that the use of estrogens in physiological replacement doses does not increase the risk of stroke in postmenopausal women.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Mann J. I., Vessey M. P., Thorogood M., Doll S. R. Myocardial infarction in young women with special reference to oral contraceptive practice. Br Med J. 1975 May 3;2(5965):241–245. doi: 10.1136/bmj.2.5965.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
- Pfeffer R. I., Van Den Noort S. Estrogen use and stroke risk in postmenopausal women. Am J Epidemiol. 1976 May;103(5):445–456. doi: 10.1093/oxfordjournals.aje.a112246. [DOI] [PubMed] [Google Scholar]
- Rosenberg L., Armstrong B., Jick H. Myocardial infarction and estrogen therapy in post-menopausal women. N Engl J Med. 1976 Jun 3;294(23):1256–1259. doi: 10.1056/NEJM197606032942302. [DOI] [PubMed] [Google Scholar]
- Stern M. P., Brown B. W., Jr, Haskell W. L., Farquhar J. W., Wehrle C. L., Wood P. D. Cardiovascular risk and use of estrogens or estrogen-progestagen combinations. Stanford three-community study. JAMA. 1976 Feb 23;235(8):811–815. [PubMed] [Google Scholar]