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. 1981 Oct;135(4):276–284.

Malignant Lymphomas: Cell Surface Markers and Advances in Classification

James A Strauchen 1
PMCID: PMC1273170  PMID: 6979127

Abstract

Identification of cell surface markers permits detailed analysis and classification of the cells involved in the immune response. Application of these techniques to the study of malignant lymphomas has led to our understanding of these tumors as neoplasms of specific elements of the immune system. This approach, which emphasizes functional characteristics of the neoplastic cells, promises to revolutionize the diagnosis and classification of the lymphomas and replace classifications based solely on morphology.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aisenberg A. C., Bloch K. J., Long J. C. Cell-surface immunoglobulins in chronic lymphocytic leukemia and allied disorders. Am J Med. 1973 Aug;55(2):184–191. doi: 10.1016/0002-9343(73)90167-8. [DOI] [PubMed] [Google Scholar]
  2. Aisenberg A. C., Wilkes B. Lymphosarcoma cell leukemia: the contribution of cell surface study to diagnosis. Blood. 1976 Nov;48(5):707–715. [PubMed] [Google Scholar]
  3. Arseneau J. C., Canellos G. P., Banks P. M., Berard C. W., Gralnick H. R., DeVita V. T., Jr American Burkitt's lymphoma: a clinicopathologic study of 30 cases. I. Clinical factors relating to prolonged survival. Am J Med. 1975 Mar;58(3):314–321. doi: 10.1016/0002-9343(75)90597-5. [DOI] [PubMed] [Google Scholar]
  4. BURKITT D. A sarcoma involving the jaws in African children. Br J Surg. 1958 Nov;46(197):218–223. doi: 10.1002/bjs.18004619704. [DOI] [PubMed] [Google Scholar]
  5. Baird S., Raschke W. The pattern of involvement of murine lymphoid tissues by primary lymphomas of different cell lineage. Hum Pathol. 1978 Jan;9(1):47–50. doi: 10.1016/s0046-8177(78)80006-9. [DOI] [PubMed] [Google Scholar]
  6. Baltimore D. Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes? Nature. 1974 Mar 29;248(447):409–411. doi: 10.1038/248409a0. [DOI] [PubMed] [Google Scholar]
  7. Banks P. M., Arseneau J. C., Gralnick H. R., Canellos G. P., DeVita V. T., Jr, Berard C. W. American Burkitt's lymphoma: a clinicopathologic study of 30 cases. II. Pathologic correlations. Am J Med. 1975 Mar;58(3):322–329. doi: 10.1016/0002-9343(75)90598-7. [DOI] [PubMed] [Google Scholar]
  8. Barr R. D., Sarin P. S., Perry S. M. Terminal transferase in human bone-marrow lymphocytes. Lancet. 1976 Mar 6;1(7958):508–509. doi: 10.1016/s0140-6736(76)90295-6. [DOI] [PubMed] [Google Scholar]
  9. Berard C. W., Greene M. H., Jaffe E. S., Magrath I., Ziegler J. NIH conference. A multidisciplinary approach to non-hodgkin's lymphomas. Ann Intern Med. 1981 Feb;94(2):218–235. doi: 10.7326/0003-4819-94-2-218. [DOI] [PubMed] [Google Scholar]
  10. Berard C. W., Jaffe E. S., Braylan R. C., Mann R. B., Nanba K. Immunologic aspects and pathology of the malignant lymphomas. Cancer. 1978 Aug;42(2 Suppl):911–921. doi: 10.1002/1097-0142(197808)42:2+<911::aid-cncr2820420713>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  11. Black M. M., Jones E. W. "Lymphomatoid" pityriasis lichenoides: a variant with histological features simulating a lymphoma. A clinical and histopathological study of 15 cases with details of long term follow up. Br J Dermatol. 1972 Apr;86(4):329–347. doi: 10.1111/j.1365-2133.1972.tb05046.x. [DOI] [PubMed] [Google Scholar]
  12. Bollum F. J. Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. Blood. 1979 Dec;54(6):1203–1215. [PubMed] [Google Scholar]
  13. Braylan R. C., Jaffe E. S., Burbach J. W., Frank M. M., Johnson R. E., Berard C. W. Similarities of surface characteristics of neoplastic well-differentiated lymphocytes from solid tissues and from peripheral blood. Cancer Res. 1976 May;36(5):1619–1625. [PubMed] [Google Scholar]
  14. Broder S., Edelson R. L., Lutzner M. A., Nelson D. L., MacDermott R. P., Durm M. E., Goldman C. K., Meade B. D., Waldmann T. A. The Sézary syndrome: a malignant proliferation of helper T cells. J Clin Invest. 1976 Dec;58(6):1297–1306. doi: 10.1172/JCI108585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Brouet J. C., Flandrin G., Seligmann M. Indications of the thymus-derived nature of the proliferating cells in six patients with Sézary's syndrome. N Engl J Med. 1973 Aug 16;289(7):341–344. doi: 10.1056/NEJM197308162890703. [DOI] [PubMed] [Google Scholar]
  16. Brouet J. C., Preud'Homme J. L., Seligmann M., Bernard J. Blast cells with monoclonal surface immunoglobulin in two cases of acute blast crisis supervening on chronic lymphocytic leukaemia. Br Med J. 1973 Oct 6;4(5883):23–24. doi: 10.1136/bmj.4.5883.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Brouet J. C., Sasportes M., Flandrin G., Preud'Homme J. L., Seligmann M. Chronic lymphocytic leukaemia of T-cell origin. Immunological and clinical evaluation in eleven patients. Lancet. 1975 Nov 8;2(7941):890–893. doi: 10.1016/s0140-6736(75)92127-3. [DOI] [PubMed] [Google Scholar]
  18. Brouet J. C., Seligmann M. The immunological classification of acute lymphoblastic leukemias. Cancer. 1978 Aug;42(2 Suppl):817–827. doi: 10.1002/1097-0142(197808)42:2+<817::aid-cncr2820420703>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  19. Donlon J. A., Jaffe E. S., Braylan R. C. Terminal deoxynucleotidyl transferase activity in malignant lymphomas. N Engl J Med. 1977 Sep 1;297(9):461–464. doi: 10.1056/NEJM197709012970901. [DOI] [PubMed] [Google Scholar]
  20. Edelson R. L., Kirkpatrick C. H., Shevach E. M., Schein P. S., Smith R. W., Green I., Lutzner M. Preferential cutaneous infiltration by neoplastic thymus-derived lymphocytes. Morphologic and functional studies. Ann Intern Med. 1974 Jun;80(6):685–692. doi: 10.7326/0003-4819-80-6-685. [DOI] [PubMed] [Google Scholar]
  21. Flaxman B. A., Zelazny G., Van Scott E. J. Nonspecificity of characteristic cells in mycosis fungoides. Arch Dermatol. 1971 Aug;104(2):141–147. [PubMed] [Google Scholar]
  22. Harris N. L., Gang D. L., Quay S. C., Poppema S., Zamecnik P. C., Nelson-Rees W. A., O'Brien S. J. Contamination of Hodgkin's disease cell cultures. Nature. 1981 Jan 22;289(5795):228–230. doi: 10.1038/289228a0. [DOI] [PubMed] [Google Scholar]
  23. Huber H., Polley M. J., Linscott W. D., Fudenberg H. H., Müller-Eberhard H. J. Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G. Science. 1968 Dec 13;162(3859):1281–1283. doi: 10.1126/science.162.3859.1281. [DOI] [PubMed] [Google Scholar]
  24. Jaffe E. S., Braylan R. C., Frank M. M., Green I., Berard C. W. Heterogeneity of immunologic markers and surface morphology in childhood lymphoblastic lymphoma. Blood. 1976 Aug;48(2):213–222. [PubMed] [Google Scholar]
  25. Jaffe E. S., Braylan R. C., Nanba K., Frank M. M., Berard C. W. Functional markers: a new perspective on malignant lymphomas. Cancer Treat Rep. 1977 Sep;61(6):953–962. [PubMed] [Google Scholar]
  26. Jaffe E. S., Shevach E. M., Frank M. M., Berard C. W., Green I. Nodular lymphoma--evidence for origin from follicular B lymphocytes. N Engl J Med. 1974 Apr 11;290(15):813–819. doi: 10.1056/NEJM197404112901501. [DOI] [PubMed] [Google Scholar]
  27. Kadin M. E., Stites D. P., Levy R., Warnke R. Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin's disease. N Engl J Med. 1978 Nov 30;299(22):1208–1214. doi: 10.1056/NEJM197811302992203. [DOI] [PubMed] [Google Scholar]
  28. Kaplan H. S., Gartner S. "Sternberg-reed" giant cells of Hodgkin's Disease: cultivation in vitro, heterotransplantation, and characterization as neoplastic macrophages. Int J Cancer. 1977 Apr 15;19(4):511–525. doi: 10.1002/ijc.2910190412. [DOI] [PubMed] [Google Scholar]
  29. Leech J. Immunoglobulin-positive Reed Sternberg cells in Hodgkin's disease. Lancet. 1973 Aug 4;2(7823):265–266. doi: 10.1016/s0140-6736(73)93173-5. [DOI] [PubMed] [Google Scholar]
  30. Levy R., Warnke R., Dorfman R. F., Haimovich J. The monoclonality of human B-cell lymphomas. J Exp Med. 1977 Apr 1;145(4):1014–1028. doi: 10.1084/jem.145.4.1014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Long J. C., Zamecnik P. C., Aisenberg A. C., Atkins L. Tissue culture studies in Hodgkin's disease: Morphologic, cytogenetic, cell surface, and enzymatic properties of cultures derived from splenic tumors. J Exp Med. 1977 Jun 1;145(6):1484–1500. doi: 10.1084/jem.145.6.1484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Lukes R. J., Collins R. D. Immunologic characterization of human malignant lymphomas. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1503. doi: 10.1002/1097-0142(197410)34:8+<1488::aid-cncr2820340822>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  33. Lukes R. J., Collins R. D. Immunologic characterization of human malignant lymphomas. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1503. doi: 10.1002/1097-0142(197410)34:8+<1488::aid-cncr2820340822>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  34. Lukes R. J., Taylor C. R., Parker J. W., Lincoln T. L., Pattengale P. K., Tindle B. H. A morphologic and immunologic surface marker study of 299 cases of non-Hodgkin lymphomas and related leukemias. Am J Pathol. 1978 Feb;90(2):461–486. [PMC free article] [PubMed] [Google Scholar]
  35. Lukes R. J. The immunologic approach to the pathology of malignant lymphomas. Am J Clin Pathol. 1979 Oct;72(4 Suppl):657–669. [PubMed] [Google Scholar]
  36. Lutzner M. A., Jordan H. W. The ultrastructure of an abnormal cell in Sézary's syndrome. Blood. 1968 Jun;31(6):719–726. [PubMed] [Google Scholar]
  37. Mann R. B., Jaffe E. S., Braylan R. C., Nanba K., Frank M. M., Ziegler J. L., Berard C. W. Non-endemic Burkitts's lymphoma. A B-cell tumor related to germinal centers. N Engl J Med. 1976 Sep 23;295(13):685–691. doi: 10.1056/NEJM197609232951301. [DOI] [PubMed] [Google Scholar]
  38. Mason D. Y., Taylor C. R. The distribution of muramidase (lysozyme) in human tissues. J Clin Pathol. 1975 Feb;28(2):124–132. doi: 10.1136/jcp.28.2.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. McCaffrey R., Smoler D. F., Baltimore D. Terminal deoxynucleotidyl transferase in a case of childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 1973 Feb;70(2):521–525. doi: 10.1073/pnas.70.2.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Nanba K., Jaffe E. S., Braylan R. C., Soban E. J., Berard C. W. Alkaline phosphatase-positive malignant lymphoma. A subtype of B-cell lymphomas. Am J Clin Pathol. 1977 Nov;68(5):535–542. doi: 10.1093/ajcp/68.5.535. [DOI] [PubMed] [Google Scholar]
  41. Nathwani B. N., Kim H., Rappaport H. Malignant lymphoma, lymphoblastic. Cancer. 1976 Aug;38(2):964–983. doi: 10.1002/1097-0142(197608)38:2<964::aid-cncr2820380248>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  42. Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Pangalis G. A., Nathwani B. N., Rappaport H. Malignant lymphoma, well differentiated lymphocytic: its relationship with chronic lymphocytic leukemia and macroglobulinemia of Waldenström. Cancer. 1977 Mar;39(3):999–1010. doi: 10.1002/1097-0142(197703)39:3<999::aid-cncr2820390302>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  44. Rappaport H., Thomas L. B. Mycosis fungoides: the pathology of extracutaneous involvement. Cancer. 1974 Oct;34(4):1198–1229. doi: 10.1002/1097-0142(197410)34:4<1198::aid-cncr2820340431>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  45. Risdall R. J., McKenna R. W., Nesbit M. E., Krivit W., Balfour H. H., Jr, Simmons R. L., Brunning R. D. Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979 Sep;44(3):993–1002. doi: 10.1002/1097-0142(197909)44:3<993::aid-cncr2820440329>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  46. Sen L., Borella L. Clinical importance of lymphoblasts with T markers in childhood acute leukemia. N Engl J Med. 1975 Apr 17;292(16):828–832. doi: 10.1056/NEJM197504172921604. [DOI] [PubMed] [Google Scholar]
  47. Shevach E. M., Jaffe E. S., Green I. Receptors for complement and immunoglobulin on human and animal lymphoid cells. Transplant Rev. 1973;16:3–28. doi: 10.1111/j.1600-065x.1973.tb00115.x. [DOI] [PubMed] [Google Scholar]
  48. Shiftan T. A., Mendelsohn J. The circulating "atypical" lymphocyte. Hum Pathol. 1978 Jan;9(1):51–61. doi: 10.1016/s0046-8177(78)80007-0. [DOI] [PubMed] [Google Scholar]
  49. Stamper H. B., Jr, Woodruff J. J. Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J Exp Med. 1976 Sep 1;144(3):828–833. doi: 10.1084/jem.144.3.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Strauchen J. A., Young R. C., DeVita V. T., Jr, Anderson T., Fantone J. C., Berard C. W. Clinical relevance of the histopathological subclassification of diffuse "histiocytic" lymphoma. N Engl J Med. 1978 Dec 21;299(25):1382–1387. doi: 10.1056/NEJM197812212992503. [DOI] [PubMed] [Google Scholar]
  51. Vogler L. B., Crist W. M., Bockman D. E., Pearl E. R., Lawton A. R., Cooper M. D. Pre-B-cell leukemia. A new phenotype of childhood lymphoblastic leukemia. N Engl J Med. 1978 Apr 20;298(16):872–878. doi: 10.1056/NEJM197804202981603. [DOI] [PubMed] [Google Scholar]
  52. Waldron J. A., Leech J. H., Glick A. D., Flexner J. M., Collins R. D. Malignant lymphoma of peripheral T-lymphocyte origin: immunologic, pathologic, and clinical features in six patients. Cancer. 1977 Oct;40(4):1604–1617. doi: 10.1002/1097-0142(197710)40:4<1604::aid-cncr2820400433>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  53. Warnke R. A., Kim H., Dorfman R. F. Malignant histiocytosis (histiocytic medullary reticulosis). I. Clinicopatholigic study of 29 cases. Cancer. 1975 Jan;35(1):215–230. doi: 10.1002/1097-0142(197501)35:1<215::aid-cncr2820350127>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  54. Warnke R., Miller R., Grogan T., Pederson M., Dilley J., Levy R. Immunologic phenotype in 30 patients with diffuse large-cell lymphoma. N Engl J Med. 1980 Aug 7;303(6):293–300. doi: 10.1056/NEJM198008073030601. [DOI] [PubMed] [Google Scholar]
  55. van Furth R. Origin and kinetics of monocytes and macrophages. Semin Hematol. 1970 Apr;7(2):125–141. [PubMed] [Google Scholar]

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