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. 1981 Dec;135(6):441–445.

Important Infections in Elderly Persons

Thomas T Yoshikawa 1,2,3,4
PMCID: PMC1273317  PMID: 7039132

Abstract

Elderly persons are prone to more frequent or greater morbidity and higher mortality from selected infectious diseases than the average population. Factors that may affect this increased predilection or poorer prognosis include environmental exposure, normal physiological changes of aging, coexistence of chronic diseases and alteration of host defense mechanisms.

Infections to which the aged are particularly vulnerable are pneumonia, influenza, tuberculosis, urinary tract infection, Gram-negative bacteremia, intra-abdominal sepsis, soft tissue infection, infective endocarditis, bacterial meningitis, bacterial arthritis and herpes zoster infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albano W. A., Zielinski C. M., Organ C. H. Is appendicitis in the aged really different? Geriatrics. 1975 Jan;30(1 SZ):81–88. [PubMed] [Google Scholar]
  2. Almy T. P., Howell D. A. Medical progress. Diverticular disease of the colon. N Engl J Med. 1980 Feb 7;302(6):324–331. doi: 10.1056/NEJM198002073020605. [DOI] [PubMed] [Google Scholar]
  3. Ammann A. J., Schiffman G., Austrian R. The antibody responses to pneumococcal capsular polysaccharides in aged individuals. Proc Soc Exp Biol Med. 1980 Jul;164(3):312–316. doi: 10.3181/00379727-164-40868. [DOI] [PubMed] [Google Scholar]
  4. Applefeld M. M., Hornick R. B. Infective endocarditis in patients over age 60. Am Heart J. 1974 Jul;88(1):90–94. doi: 10.1016/0002-8703(74)90354-8. [DOI] [PubMed] [Google Scholar]
  5. Argen R. J., Wilson C. H., Jr, Wood P. Suppurative arthritis. Clinical features of 42 cases. Arch Intern Med. 1966 May;117(5):661–666. doi: 10.1001/archinte.117.5.661. [DOI] [PubMed] [Google Scholar]
  6. Baker P. J., Amsbaugh D. F., Stashak P. W., Caldes G., Prescott B. Regulation of the antibody response to pneumococcal polysaccharide by thymus-derived cells. Rev Infect Dis. 1981 Mar-Apr;3(2):332–341. doi: 10.1093/clinids/3.2.332. [DOI] [PubMed] [Google Scholar]
  7. Bodey G. P. Infections in cancer patients. Cancer Treat Rev. 1975 Jun;2(2):89–128. doi: 10.1016/s0305-7372(75)80005-3. [DOI] [PubMed] [Google Scholar]
  8. Brocklehurst J. C., Bee P., Jones D., Palmer M. K. Bacteriuria in geriatric hospital patients its correlates and management. Age Ageing. 1977 Nov;6(4):240–245. doi: 10.1093/ageing/6.4.240. [DOI] [PubMed] [Google Scholar]
  9. Cherubin C. E., Marr J. S., Sierra M. F., Becker S. Listeria and gram-negative bacillary meningitis in New York City, 1972-1979. Frequent causes of meningitis in adults. Am J Med. 1981 Aug;71(2):199–209. doi: 10.1016/0002-9343(81)90106-6. [DOI] [PubMed] [Google Scholar]
  10. Dontas A. S., Kasviki-Charvati P., Papanayiotou P. C., Marketos S. G. Bacteriuria and survival in old age. N Engl J Med. 1981 Apr 16;304(16):939–943. doi: 10.1056/NEJM198104163041604. [DOI] [PubMed] [Google Scholar]
  11. EICKHOFF T. C., SHERMAN I. L., SERFLING R. E. Observations on excess mortality associated with epidemic influenza. JAMA. 1961 Jun 3;176:776–782. doi: 10.1001/jama.1961.03040220024005. [DOI] [PubMed] [Google Scholar]
  12. Ebright J. R., Rytel M. W. Bacterial pneumonia in the elderly. J Am Geriatr Soc. 1980 May;28(5):220–223. doi: 10.1111/j.1532-5415.1980.tb00523.x. [DOI] [PubMed] [Google Scholar]
  13. Finland M., Barnes M. W. Acute bacterial meningitis at Boston City Hospital during 12 selected years, 1935-1972. J Infect Dis. 1977 Sep;136(3):400–415. doi: 10.1093/infdis/136.3.400. [DOI] [PubMed] [Google Scholar]
  14. Fraser D. W., Henke C. E., Feldman R. A. Changing patterns of bacterial meningitis in Olmsted County, Minnesota, 1935-1970. J Infect Dis. 1973 Sep;128(3):300–307. doi: 10.1093/infdis/128.3.300. [DOI] [PubMed] [Google Scholar]
  15. Freeman J., McGowan J. E., Jr Risk factors for nosocomial infection. J Infect Dis. 1978 Dec;138(6):811–819. doi: 10.1093/infdis/138.6.811. [DOI] [PubMed] [Google Scholar]
  16. Galpin J. E., Chow A. W., Bayer A. S., Guze L. B. Sepsis associated with decubitus ulcers. Am J Med. 1976 Sep;61(3):346–350. doi: 10.1016/0002-9343(76)90371-5. [DOI] [PubMed] [Google Scholar]
  17. Garb J. L., Brown R. B., Garb J. R., Tuthill R. W. Differences in etiology of pneumonias in nursing home and community patients. JAMA. 1978 Nov 10;240(20):2169–2172. [PubMed] [Google Scholar]
  18. Gardner I. D. The effect of aging on susceptibility to infection. Rev Infect Dis. 1980 Sep-Oct;2(5):801–810. doi: 10.1093/clinids/2.5.801. [DOI] [PubMed] [Google Scholar]
  19. Garvey G. J., Neu H. C. Infective endocarditis--an evolving disease. A review of endocarditis at the Columbia-Presbyterian Medical Center, 1968-1973. Medicine (Baltimore) 1978 Mar;57(2):105–127. [PubMed] [Google Scholar]
  20. Gladstone J. L., Recco R. Host factors and infectious diseases in the elderly. Med Clin North Am. 1976;60(6):1225–1240. doi: 10.1016/s0025-7125(16)31878-8. [DOI] [PubMed] [Google Scholar]
  21. Goldenberg D. L., Brandt K. D., Cathcart E. S., Cohen A. S. Acute arthritis caused by gram-negative bacilli: a clinical characterization. Medicine (Baltimore) 1974 May;53(3):197–208. doi: 10.1097/00005792-197405000-00003. [DOI] [PubMed] [Google Scholar]
  22. Goldenberg D. L., Cohen A. S. Acute infectious arthritis. A review of patients with nongonococcal joint infections (with emphasis on therapy and prognosis). Am J Med. 1976 Mar;60(3):369–377. doi: 10.1016/0002-9343(76)90753-1. [DOI] [PubMed] [Google Scholar]
  23. Harbrecht P. J., Garrison R. N., Fry D. E. Surgery in elderly patients. South Med J. 1981 May;74(5):594–598. doi: 10.1097/00007611-198105000-00023. [DOI] [PubMed] [Google Scholar]
  24. Hewitt W. L., Sanford J. P. Workshop on hospital-associated infections. J Infect Dis. 1974 Dec;130(6):680–686. doi: 10.1093/infdis/130.6.680. [DOI] [PubMed] [Google Scholar]
  25. Hodgin U. G., Sanford J. P. Gram-negative rod bacteremia. An analysis of 100 patients. Am J Med. 1965 Dec;39(6):952–960. doi: 10.1016/0002-9343(65)90118-x. [DOI] [PubMed] [Google Scholar]
  26. Howells C. H., Vesselinova-Jenkins C. K., Evans A. D., James J. Influenza vaccination and mortality from bronchopneumonia in the elderly. Lancet. 1975 Feb 15;1(7903):381–383. doi: 10.1016/s0140-6736(75)91291-x. [DOI] [PubMed] [Google Scholar]
  27. Infection and diabetes mellitus. West J Med. 1979 Jun;130(6):515–521. [PMC free article] [PubMed] [Google Scholar]
  28. Keighley M. R., Drysdale R. B., Quoraishi A. H., Burdon D. W., Alexander-Williams J. Antibiotic treatment of biliary sepsis. Surg Clin North Am. 1975 Dec;55(6):1379–1390. doi: 10.1016/s0039-6109(16)40797-8. [DOI] [PubMed] [Google Scholar]
  29. Kreger B. E., Craven D. E., Carling P. C., McCabe W. R. Gram-negative bacteremia. III. Reassessment of etiology, epidemiology and ecology in 612 patients. Am J Med. 1980 Mar;68(3):332–343. doi: 10.1016/0002-9343(80)90101-1. [DOI] [PubMed] [Google Scholar]
  30. Louie T. J., Bartlett J. G., Tally F. P., Gorbach S. L. Aerobic and anaerobic bacteria in diabetic foot ulcers. Ann Intern Med. 1976 Oct;85(4):461–463. doi: 10.7326/0003-4819-85-4-461. [DOI] [PubMed] [Google Scholar]
  31. Makinodan T., Kay M. M. Age influence on the immune system. Adv Immunol. 1980;29:287–330. doi: 10.1016/s0065-2776(08)60047-4. [DOI] [PubMed] [Google Scholar]
  32. Massanari R. M. Purulent meningitis in the elderly: when to suspect an unusual pathogen. Geriatrics. 1977 Mar;32(3):55–59. [PubMed] [Google Scholar]
  33. Miller L. H., Brunell P. A. Zoster, reinfection or activation of latent virus? Observations on the antibody response. Am J Med. 1970 Oct;49(4):480–483. doi: 10.1016/s0002-9343(70)80042-0. [DOI] [PubMed] [Google Scholar]
  34. Miller L. H. Herpes zoster in the elderly. Cutis. 1976 Sep;18(3):427–432. [PubMed] [Google Scholar]
  35. Mufson M. A., Kruss D. M., Wasil R. E., Metzger W. I. Capsular types and outcome of bacteremic pneumococcal disease in the antibiotic era. Arch Intern Med. 1974 Sep;134(3):505–510. [PubMed] [Google Scholar]
  36. PEARCE M. L., GUZE L. B. Some factors affecting prognosis in bacterial endocarditis. Ann Intern Med. 1961 Aug;55:270–282. doi: 10.7326/0003-4819-55-2-270. [DOI] [PubMed] [Google Scholar]
  37. Palmblad J., Haak A. Ageing does not change blood granulocyte bactericidal capacity and levels of complement factors 3 and 4. Gerontology. 1978;24(5):381–385. doi: 10.1159/000212275. [DOI] [PubMed] [Google Scholar]
  38. Peltokallio P., Jauhiainen K. Acute appendicitis in the aged patient. Study of 300 cases after the age of 60. Arch Surg. 1970 Feb;100(2):140–143. doi: 10.1001/archsurg.1970.01340200028006. [DOI] [PubMed] [Google Scholar]
  39. Phair J. P. Aging and infection: a review. J Chronic Dis. 1979;32(7):535–540. doi: 10.1016/0021-9681(79)90115-2. [DOI] [PubMed] [Google Scholar]
  40. Phair J. P., Kauffman C. A., Bjornson A., Gallagher J., Adams L., Hess E. V. Host defenses in the aged: evaluation of components of the inflammatory and immune responses. J Infect Dis. 1978 Jul;138(1):67–73. doi: 10.1093/infdis/138.1.67. [DOI] [PubMed] [Google Scholar]
  41. Phair J. P., Kauffman C. A., Bjornson A. Investigation of host defense mechanisms in the aged as determinants of nosocomial colonization and pneumonia. J Reticuloendothel Soc. 1978 May;23(5):397–405. [PubMed] [Google Scholar]
  42. Powell K. E., Farer L. S. The rising age of the tuberculosis patient: a sign of success and failure. J Infect Dis. 1980 Dec;142(6):946–948. doi: 10.1093/infdis/142.6.946. [DOI] [PubMed] [Google Scholar]
  43. Riley H. D. Hospital-acquired infections. South Med J. 1977 Nov;70(11):1265–1267. [PubMed] [Google Scholar]
  44. Roberts-Thomson I. C., Whittingham S., Youngchaiyud U., Mackay I. R. Ageing, immune response, and mortality. Lancet. 1974 Aug 17;2(7877):368–370. doi: 10.1016/s0140-6736(74)91755-3. [DOI] [PubMed] [Google Scholar]
  45. Romano J. M., Kaye D. UTI in the elderly: common yet atypical. Geriatrics. 1981 Jun;36(6):113-5, 120. [PubMed] [Google Scholar]
  46. Shuman C. R. Clinical pearls in the use of insulin in the elderly diabetic. Geriatrics. 1980 Mar;35(3):47–64. [PubMed] [Google Scholar]
  47. Singer C., Kaplan M. H., Armstrong D. Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am J Med. 1977 May;62(5):731–742. doi: 10.1016/0002-9343(77)90876-2. [DOI] [PubMed] [Google Scholar]
  48. Stead W. W. Tuberculosis among elderly persons: an outbreak in a nursing home. Ann Intern Med. 1981 May;94(5):606–610. doi: 10.7326/0003-4819-94-5-606. [DOI] [PubMed] [Google Scholar]
  49. Thell R., Martin F. H., Edwards J. E. Bacterial endocarditis in subjects 60 years of age and older. Circulation. 1975 Jan;51(1):174–182. doi: 10.1161/01.cir.51.1.174. [DOI] [PubMed] [Google Scholar]
  50. Valenti W. M., Trudell R. G., Bentley D. W. Factors predisposing to oropharyngeal colonization with gram-negative bacilli in the aged. N Engl J Med. 1978 May 18;298(20):1108–1111. doi: 10.1056/NEJM197805182982002. [DOI] [PubMed] [Google Scholar]
  51. WEIL M. H., SHUBIN H., BIDDLE M. SHOCK CAUSED BY GRAM-NEGATIVE MICROORGANISMS. ANALYSIS OF 169 CASES. Ann Intern Med. 1964 Mar;60:384–400. doi: 10.7326/0003-4819-60-3-384. [DOI] [PubMed] [Google Scholar]
  52. WOLFSON S. A., KALMANSON G. M., RUBINI M. E., GUZE L. B. EPIDEMIOLOGY OF BACTERIURIA IN A PREDOMINANTLY GERIATRIC MALE POPULATION. Am J Med Sci. 1965 Aug;250:168–173. doi: 10.1097/00000441-196508000-00007. [DOI] [PubMed] [Google Scholar]
  53. Weinstein L., Rubin R. H. Infective endocarditis--1973. Prog Cardiovasc Dis. 1973 Nov-Dec;16(3):239–274. doi: 10.1016/s0033-0620(73)80001-5. [DOI] [PubMed] [Google Scholar]
  54. Williams G. O. Vaccines in older patients: combating the risk of mortality. Geriatrics. 1980 Nov;35(11):55-7, 63-4. [PubMed] [Google Scholar]

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