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. 2025 Dec 15;16:1734058. doi: 10.3389/fphar.2025.1734058

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity

Hui-Fang Deng 1,, Lan-Xin Yue 1,, Ning-Ning Wang 1,2,, Yong-Qiang Zhou 1,, Wei Zhou 1, Xian Liu 1, Yu-Hao Ni 1, Cong-Shu Huang 1,3, Li-Zhen Qiu 1,2, Hong Liu 1,3, Hong-Ling Tan 1, Xiang-Lin Tang 1, Yu-Guang Wang 1, Zeng-Chun Ma 1, Yue Gao 1,2,*
PMCID: PMC12745867  PMID: 41472795

There was a mistake in Figure 2 as published. The image for the DFO group in Figure 2C was mistakenly replaced with the control group’s image, resulting in partial overlap between Figure 1C and Figure 2C. Additionally, to prevent misinterpretation of the ALI (25 μM) groups in Figures 1C and Figure 2C, we have used new images for the ALI group in Figure 2C. Finally, the housekeeping protein β-actin in Figure 2E was inadvertently duplicated from Figure 5C, and we have corrected this error. The corrected Figure 2 appears below.

FIGURE 2.

Bar graphs, fluorescence images, and Western blot results illustrating effects of different treatments: A) Cell viability comparison among control, DFO, ALI, and DFO+ALI groups. B) Fe2+ concentration levels. C) Fluorescence microscopy images for control, DFO, ALI, and DFO+ALI groups. D) GSH-MBB fluorescence intensity histogram. E) Western blot showing 4-HNE expression against β-actin. F) Bar graph of 4-HNE/β-actin ratio across groups. Statistical significance is indicated with asterisks and hashes.

ALI-induced cytotoxicity could be alleviated by iron chelator DFO. (A) Cell viability of HK-2 cells was detected using CCK-8 assay. (B) Intracellular Fe2+ levels in HK-2 cells treated by ALI and DFO. (C,D) Intracellular GSH content in HK-2 (X200). (E,F) The protein levels of 4-HNE were measured by Western blot. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. the control group; # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001 vs. the ALI group.

The original article has been updated.

Footnotes

Edited and reviewed by: Ying-Yong Zhao, Northwest University, China

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