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. 1981 Mar;312:335–344. doi: 10.1113/jphysiol.1981.sp013631

GABA-antagonists and spatial summation in Y-type cat retinal ganglion cells.

A W Kirby, D E Schweitzer-Tong
PMCID: PMC1275556  PMID: 7264997

Abstract

1. The effect of GABA-antagonists on centre size of Y-type retinal ganglion cells was measured under conditions which ensured that cells were rod driven. 2. Both bicuculline and picrotoxin, administered intravenously, led to reliable and reversible changes in centre size as determined by area-sensitivity measurements. 3. The administration of GABA-antagonists produced opposite results in on- and off-centre cells; the centre summing area decreased in on-centre cells and increased in off-centre cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cleland B. G., Enroth-cugell C. Quantitative aspects of sensitivity and summation in the cat retina. J Physiol. 1968 Sep;198(1):17–38. doi: 10.1113/jphysiol.1968.sp008591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cleland B. G., Levick W. R., Sanderson K. J. Properties of sustained and transient ganglion cells in the cat retina. J Physiol. 1973 Feb;228(3):649–680. doi: 10.1113/jphysiol.1973.sp010105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Enroth-Cugell C., Hertz G., Lennie P. Cone signals in the cat's retina. J Physiol. 1977 Jul;269(2):273–296. doi: 10.1113/jphysiol.1977.sp011902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Enroth-Cugell C., Robson J. G. The contrast sensitivity of retinal ganglion cells of the cat. J Physiol. 1966 Dec;187(3):517–552. doi: 10.1113/jphysiol.1966.sp008107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Enroth-Cugell C., Shapley R. M. Flux, not retinal illumination, is what cat retinal ganglion cells really care about. J Physiol. 1973 Sep;233(2):311–326. doi: 10.1113/jphysiol.1973.sp010309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hochstein S., Shapley R. M. Linear and nonlinear spatial subunits in Y cat retinal ganglion cells. J Physiol. 1976 Nov;262(2):265–284. doi: 10.1113/jphysiol.1976.sp011595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hochstein S., Shapley R. M. Quantitative analysis of retinal ganglion cell classifications. J Physiol. 1976 Nov;262(2):237–264. doi: 10.1113/jphysiol.1976.sp011594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hubel D. H. Tungsten Microelectrode for Recording from Single Units. Science. 1957 Mar 22;125(3247):549–550. doi: 10.1126/science.125.3247.549. [DOI] [PubMed] [Google Scholar]
  9. Kirby A. W., Enroth-Cugell C. The involvement of gamma-aminobutyric acid in the organization of cat retinal ganglion cell receptive fields. A study with picrotoxin and bicuculline. J Gen Physiol. 1976 Oct;68(4):465–484. doi: 10.1085/jgp.68.4.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kolb H. The inner plexiform layer in the retina of the cat: electron microscopic observations. J Neurocytol. 1979 Jun;8(3):295–329. doi: 10.1007/BF01236124. [DOI] [PubMed] [Google Scholar]
  11. Levick W. R. Another tungsten microelectrode. Med Biol Eng. 1972 Jul;10(4):510–515. doi: 10.1007/BF02474199. [DOI] [PubMed] [Google Scholar]
  12. Linsenmeier R. A., Hertz B. G. Eye movements in paralyzed cats induced by drugs and sympathetic stimulation. Vision Res. 1979;19(11):1249–1252. doi: 10.1016/0042-6989(79)90191-3. [DOI] [PubMed] [Google Scholar]
  13. Marshall J., Voaden M. Autoradiographic identification of the cells accumulating 3H gamma-aminobutyric acid in mammalian retinae: a species comparison. Vision Res. 1975 Mar;15(3):459–461. doi: 10.1016/0042-6989(75)90102-9. [DOI] [PubMed] [Google Scholar]
  14. Nelson R. Cat cones have rod input: a comparison of the response properties of cones and horizontal cell bodies in the retina of the cat. J Comp Neurol. 1977 Mar 1;172(1):109–135. doi: 10.1002/cne.901720106. [DOI] [PubMed] [Google Scholar]
  15. Nelson R., Famiglietti E. V., Jr, Kolb H. Intracellular staining reveals different levels of stratification for on- and off-center ganglion cells in cat retina. J Neurophysiol. 1978 Mar;41(2):472–483. doi: 10.1152/jn.1978.41.2.472. [DOI] [PubMed] [Google Scholar]
  16. RUSHTON W. A. VISUAL ADAPTATION. Proc R Soc Lond B Biol Sci. 1965 Mar 16;162:20–46. doi: 10.1098/rspb.1965.0024. [DOI] [PubMed] [Google Scholar]
  17. Rodieck R. W. Quantitative analysis of cat retinal ganglion cell response to visual stimuli. Vision Res. 1965 Dec;5(11):583–601. doi: 10.1016/0042-6989(65)90033-7. [DOI] [PubMed] [Google Scholar]

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