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. 1994 Jan;66(1):259–267. doi: 10.1016/S0006-3495(94)80775-1

MR diffusion tensor spectroscopy and imaging.

P J Basser 1, J Mattiello 1, D LeBihan 1
PMCID: PMC1275686  PMID: 8130344

Abstract

This paper describes a new NMR imaging modality--MR diffusion tensor imaging. It consists of estimating an effective diffusion tensor, Deff, within a voxel, and then displaying useful quantities derived from it. We show how the phenomenon of anisotropic diffusion of water (or metabolites) in anisotropic tissues, measured noninvasively by these NMR methods, is exploited to determine fiber tract orientation and mean particle displacements. Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined. They coincide with the eigenvectors of Deff, while the effective diffusivities along these orthotropic directions are the eigenvalues of Deff. Diffusion ellipsoids, constructed in each voxel from Deff, depict both these orthotropic axes and the mean diffusion distances in these directions. Moreover, the three scalar invariants of Deff, which are independent of the tissue's orientation in the laboratory frame of reference, reveal useful information about molecular mobility reflective of local microstructure and anatomy. Inherently tensors (like Deff) describing transport processes in anisotropic media contain new information within a macroscopic voxel that scalars (such as the apparent diffusivity, proton density, T1, and T2) do not.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chenevert T. L., Brunberg J. A., Pipe J. G. Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. Radiology. 1990 Nov;177(2):401–405. doi: 10.1148/radiology.177.2.2217776. [DOI] [PubMed] [Google Scholar]
  2. Cleveland G. G., Chang D. C., Hazlewood C. F., Rorschach H. E. Nuclear magnetic resonance measurement of skeletal muscle: anisotrophy of the diffusion coefficient of the intracellular water. Biophys J. 1976 Sep;16(9):1043–1053. doi: 10.1016/S0006-3495(76)85754-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cory D. G., Garroway A. N. Measurement of translational displacement probabilities by NMR: an indicator of compartmentation. Magn Reson Med. 1990 Jun;14(3):435–444. doi: 10.1002/mrm.1910140303. [DOI] [PubMed] [Google Scholar]
  4. Doran M., Hajnal J. V., Van Bruggen N., King M. D., Young I. R., Bydder G. M. Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences. J Comput Assist Tomogr. 1990 Nov-Dec;14(6):865–873. doi: 10.1097/00004728-199011000-00001. [DOI] [PubMed] [Google Scholar]
  5. Douek P., Turner R., Pekar J., Patronas N., Le Bihan D. MR color mapping of myelin fiber orientation. J Comput Assist Tomogr. 1991 Nov-Dec;15(6):923–929. doi: 10.1097/00004728-199111000-00003. [DOI] [PubMed] [Google Scholar]
  6. Fullerton G. D., Cameron I. L., Ord V. A. Orientation of tendons in the magnetic field and its effect on T2 relaxation times. Radiology. 1985 May;155(2):433–435. doi: 10.1148/radiology.155.2.3983395. [DOI] [PubMed] [Google Scholar]
  7. Le Bihan D., Breton E., Lallemand D., Grenier P., Cabanis E., Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986 Nov;161(2):401–407. doi: 10.1148/radiology.161.2.3763909. [DOI] [PubMed] [Google Scholar]
  8. Le Bihan D., Turner R., Douek P. Is water diffusion restricted in human brain white matter? An echo-planar NMR imaging study. Neuroreport. 1993 Jul;4(7):887–890. doi: 10.1097/00001756-199307000-00012. [DOI] [PubMed] [Google Scholar]
  9. Moseley M. E., Cohen Y., Kucharczyk J., Mintorovitch J., Asgari H. S., Wendland M. F., Tsuruda J., Norman D. Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology. 1990 Aug;176(2):439–445. doi: 10.1148/radiology.176.2.2367658. [DOI] [PubMed] [Google Scholar]
  10. Turner R., Le Bihan D., Maier J., Vavrek R., Hedges L. K., Pekar J. Echo-planar imaging of intravoxel incoherent motion. Radiology. 1990 Nov;177(2):407–414. doi: 10.1148/radiology.177.2.2217777. [DOI] [PubMed] [Google Scholar]

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