Abstract
Celiprolol (400 mg) and atenolol (100 mg) were given once a day to 16 patients with stable angina pectoris in a double blind placebo controlled crossover study. Celiprolol produced less suppression of heart rate both at rest and during exercise than atenolol. Both drugs were equally effective in reducing the frequency of angina and in delaying the onset of ischaemia during exercise. Radionuclide ventriculography showed that atenolol but not celiprolol lowered cardiac output at rest and during exercise. Thus the ancillary properties of celiprolol, including partial beta 2 agonist activity and direct vasodilating activity, have detectable effects on cardiac function that may be beneficial in patients with angina.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Battock D. J., Alvarez H., Chidsey C. A. Effects of propranolol and isosorbide dinitrate on exercise performance and adrenergic acitivity in patients with angina pectoris. Circulation. 1969 Feb;39(2):157–169. doi: 10.1161/01.cir.39.2.157. [DOI] [PubMed] [Google Scholar]
- Caruso F. S., Doshan H. D., Hernandez P. H., Costello R., Applin W., Neiss E. S. Celiprolol: pharmacokinetics and duration of pharmacodynamic activity. Br J Clin Pract Suppl. 1985 Jun;40:12–16. [PubMed] [Google Scholar]
- Eff J., Godfrey J., Garutti R., Capone P. Celiprolol in angina pectoris: a controlled study. J Cardiovasc Pharmacol. 1986;8 (Suppl 4):S132–S134. doi: 10.1097/00005344-198608004-00030. [DOI] [PubMed] [Google Scholar]
- Kirby W. M., De Maine J. B., Serrill W. S. Pharmacokinetics of the cephalosporins in healthy volunteers and uremic patients. Postgrad Med J. 1971 Feb;47(Suppl):41–46. [PubMed] [Google Scholar]
- Nelson R. R., Gobel F. L., Jorgensen C. R., Wang K., Wang Y., Taylor H. L. Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise. Circulation. 1974 Dec;50(6):1179–1189. doi: 10.1161/01.cir.50.6.1179. [DOI] [PubMed] [Google Scholar]
- Robinson B. F. Mode of action of nitrglycerin in angina pectoris. Correlation between haemodynamic effects during exercise and prevention of pain. Br Heart J. 1968 May;30(3):295–302. doi: 10.1136/hrt.30.3.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor S. H. Beta-blocking drugs and myocardial function. J Cardiovasc Pharmacol. 1986;8 (Suppl 4):S75–S82. doi: 10.1097/00005344-198608004-00014. [DOI] [PubMed] [Google Scholar]
- Taylor S. H., Silke B. Coronary insufficiency and beta-blockade. J Cardiovasc Pharmacol. 1985;7 (Suppl 2):S80–S89. doi: 10.1097/00005344-198507002-00016. [DOI] [PubMed] [Google Scholar]