Abstract
Experimental exposure of susceptible pregnant sows by various routes to the gut-origin transmissible gastroenteritis virus stimulated production of milk and serum antibodies. These antibodies neutralized the cytopathic effect of transmissible gastroenteritis virus propagated in cell culture. This in vitro neutralizing antibody resided in the IgG and IgA immunoglobulin classes. On the other hand, protection for baby pigs resided in the IgA class of milk immunoglobulin of sows exposed orally or intramammarily but not of sows exposed intramuscularly to the virus.
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Selected References
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- Abou-Youssef M. H., Ristic M. Distribution of antibodies to transmissible gastroenteritis virus in serum and milk of sows: isolation and identification of the immunoglobulin classes of swine serum and milk. Am J Vet Res. 1972 May;33(5):975–979. [PubMed] [Google Scholar]
- BAY W. W. Transmissible gastroenteritis in swine-field herd studies. J Am Vet Med Assoc. 1952 May;120(902):283–286. [PubMed] [Google Scholar]
- Bohl E. H., Gupta R. K., Olquin M. V., Saif L. J. Antibody responses in serum, colostrum, and milk of swine after infection or vaccination with transmissible gastroenteritis virus. Infect Immun. 1972 Sep;6(3):289–301. doi: 10.1128/iai.6.3.289-301.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cate T. R., Rossen R. D., Douglas R. G., Jr, Butler W. T., Couch R. B. The role of nasal secretion and serum antibody in the rhinovirus common cold. Am J Epidemiol. 1966 Sep;84(2):352–363. doi: 10.1093/oxfordjournals.aje.a120648. [DOI] [PubMed] [Google Scholar]
- Curtis J., Bourne F. J. Immunoglobulin quantitation in sow serum, colostrum and milk and the serum of young pigs. Biochim Biophys Acta. 1971 Apr 27;236(1):319–332. doi: 10.1016/0005-2795(71)90181-4. [DOI] [PubMed] [Google Scholar]
- HAELTERMAN E. O., HUTCHINGS L. M. Epidemic diarrheal disease of viral origin in newborn swine. Ann N Y Acad Sci. 1956 Aug 10;66(1):186–190. doi: 10.1111/j.1749-6632.1956.tb40119.x. [DOI] [PubMed] [Google Scholar]
- Kim Y. B., Bradley S. G., Watson D. W. Ontogeny of the immune response. I. Development of immunoglobulins in germfree and conventional colostrum-deprived piglets. J Immunol. 1966 Jul;97(1):52–63. [PubMed] [Google Scholar]
- Porter P., Allen W. D. Classes of immunoglobulins related to immunity in the pig. J Am Vet Med Assoc. 1972 Feb 15;160(4):511–518. [PubMed] [Google Scholar]
- Porter P., Noakes D. E., Allen W. D. Secretory IgA and antibodies to Escherichia coli in porcine colostrum and milk and their significance in the alimentary tract of the young pig. Immunology. 1970 Feb;18(2):245–257. [PMC free article] [PubMed] [Google Scholar]
- Ristic M., Abou-Youssef M. H. Comments on the immunology of transmissible gastroenteritis. J Am Vet Med Assoc. 1972 Feb 15;160(4):549–553. [PubMed] [Google Scholar]
- Smith C. B., Purcell R. H., Bellanti J. A., Chanock R. M. Protective effect of antibody to parainfluenza type 1 virus. N Engl J Med. 1966 Nov 24;275(21):1145–1152. doi: 10.1056/NEJM196611242752101. [DOI] [PubMed] [Google Scholar]
- Vaerman J. P., Arbuckle J. B., Heremans J. F. Immunoglobulin A in the pig. II. Sow's colostral and milk IgA: quantitative studies and molecular size estimation. Int Arch Allergy Appl Immunol. 1970;39(2-3):323–333. [PubMed] [Google Scholar]