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. 1975 Apr;39(2):194–207.

Investigation of factors of probable significance in the pathogenesis of pneumonic pasteurellosis in cattle.

R G Thomson, S Chander, M Savan, M L Fox
PMCID: PMC1277442  PMID: 164992

Abstract

Six groups of ten beef calves six to eight months of age were shipped from western Canada and observed untreated for one week after arrival. The following parameters were measured daily: body temperature, plasma fibrinogen, nasal bacterial mean colony counts of Pasteurella hemolytica and Pasteurella multocida, total and differential leukoyte counts, packed cell volumes and the following, twice during the week: serum and nasal antibody titres to P. hemolytica and parainfluenza-3 virus. The lungs from 44 of the calves were obtained at post mortem and given a numerical score based on the degree of pneumonia present. Animals were designated SICK and WELL according to body temperature and plasma fibrinogen. The SICK animals had higher nasal mean colony counts of P. hemolytica than the WELL animals. The SICK animals had lower levels of serum antibody to P. hemolytica than the WELL on day 1 but had a greater rise in titre over the week than did the WELL animals. Both groups were similar with regard to serum antibody to parainfluenza-3 virus and there was little change in these titres. The SICK animals had a much greater degree of pneumonia than the WELL. The values of some of the parameters were combined with the data of previously studied animals in order to provide a comparison of SICK and WELL with larger numbers of animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIBERSTEIN E. L., GILLS M., KNIGHT H. Serological types of Pasteurella hemolytica. Cornell Vet. 1960 Jul;50:283–300. [PubMed] [Google Scholar]
  2. Baldwin D. E., Marshall R. G., Wessman G. E. Experimental infection of calves with myxovirus parainfluenza-3 and Pasteurella haemolytica. Am J Vet Res. 1967 Nov;28(127):1773–1782. [PubMed] [Google Scholar]
  3. COLLIER J. R., BROWN W. W., Jr, CHOW T. L. Microbiologic investigations of natural epizootics of shipping fever of cattle. J Am Vet Med Assoc. 1962 Apr 15;140:807–810. [PubMed] [Google Scholar]
  4. Carter G. R., McSherry B. J. Further Observations On Shipping Fever In Canada. Can J Comp Med Vet Sci. 1955 Jun;19(6):177–181. [PMC free article] [PubMed] [Google Scholar]
  5. Carter G. R. Observations On The Pathology And Bacteriology Of Shipping Fever In Canada. Can J Comp Med Vet Sci. 1954 Oct;18(10):359–364. [PMC free article] [PubMed] [Google Scholar]
  6. Duncan J. R., Thomson R. G. Influence of immunization procedures on upper respiratory tract immunity in cattle. Can J Comp Med. 1970 Jan;34(1):94–100. [PMC free article] [PubMed] [Google Scholar]
  7. Frank G. H., Marshall R. G. Relationship of serum and nasal secretion-neutralizing antibodies in protection of calves against parainfluenza-3 virus. Am J Vet Res. 1971 Nov;32(11):1707–1713. [PubMed] [Google Scholar]
  8. Gilka F., Thomson R. G., Savan M. The effect of edema, hydrocortisone acetate, concurrent viral infection and immunization on the clearance of Pasteurella hemolytica from the bovine lung. Can J Comp Med. 1974 Jul;38(3):251–259. [PMC free article] [PubMed] [Google Scholar]
  9. Grey C. L., Thomson R. G. Pasteurella haemolytica in the tracheal air of calves. Can J Comp Med. 1971 Apr;35(2):121–128. [PMC free article] [PubMed] [Google Scholar]
  10. Jakab G. J., Green G. M. Immune enhancement of pulmonary bactericidal activity in murine virus pneumonia. J Clin Invest. 1973 Nov;52(11):2878–2884. doi: 10.1172/JCI107484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Knight H. D., Biberstein E. L., Allison M. The role of capsular and somatic antigens in immunization of mice against Pasteurella hemolytica infection. Cornell Vet. 1969 Jan;59(1):55–64. [PubMed] [Google Scholar]
  12. McSherry B. J., Horney F. D., DeGroot J. J. Plasma fibrinogen levels in normal and sick cows. Can J Comp Med. 1970 Jul;34(3):191–197. [PMC free article] [PubMed] [Google Scholar]
  13. Morse E. E., Panek S., Menga R. Automated fibrinogen determination. Am J Clin Pathol. 1971 Jun;55(6):671–676. doi: 10.1093/ajcp/55.6.671. [DOI] [PubMed] [Google Scholar]
  14. Rice C. E., Beauregard M., Maybee T. K. Survey of Shipping Fever in Canada: Serological Studies. Can J Comp Med Vet Sci. 1955 Nov;19(11):329–349. [PMC free article] [PubMed] [Google Scholar]
  15. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  16. Schell K., Sanderson R. P., Whalen J. W., Bittle J. L. The antigenicity of multivalent vaccines for bovine respiratory disease. Cornell Vet. 1972 Jan;62(1):101–109. [PubMed] [Google Scholar]
  17. Sweat R. L. Epizootiologic studies of bovine myxovirus parainfluenza 3. J Am Vet Med Assoc. 1967 Jan 15;150(2):178–183. [PubMed] [Google Scholar]
  18. Sweat R. L. Isolation of myxovirus parainfluenza 3 from cattle with respiratory diseases. J Am Vet Med Assoc. 1967 Jan 15;150(2):172–177. [PubMed] [Google Scholar]
  19. Thomson G. W., McSherry B. J., Valli V. E. Evaluation of a rapid method of determination of plasma fibrinogen. Can J Comp Med. 1974 Jul;38(3):266–270. [PMC free article] [PubMed] [Google Scholar]
  20. Thomson R. G., Benson M. L., Savan M. Pneumonic pasteurellosis of cattle: microbiology and immunology. Can J Comp Med. 1969 Jul;33(3):194–206. [PMC free article] [PubMed] [Google Scholar]
  21. Thomson R. G., Gilka F. A brief review of pulmonary clearance of bacterial aerosols emphasizing aspects of particular relevance to veterinary medicine. Can Vet J. 1974 Apr;15(4):99–107. [PMC free article] [PubMed] [Google Scholar]
  22. Thomson R. G. Pathology and pathogenesis of the common diseases of the respiratory tract of cattle. Can Vet J. 1974 Sep;15(9):249–251. [PMC free article] [PubMed] [Google Scholar]
  23. Wray C., Thompson D. A. An epidemiological study of Pasteurella haemolytica in calves. Br Vet J. 1973 Mar-Apr;129(2):116–123. doi: 10.1016/s0007-1935(17)36534-x. [DOI] [PubMed] [Google Scholar]

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