Abstract
Glucose-glucagon relationships were examined in adult sheep. Hyperglycemia was induced by infusing glucose at 120 mg/hr/kg body weight. Hypoglycemia was obtained by infusing insulin at 1.2 U/hr. In several experiments glucose at 40 mg/hr/kg was infused with insulin to obtain hyperinsulinemia without hypoglycemia to distinguish glucose-insulin effects. Glucagon concentrations decreased during hyperglycemia and increased during hypoglycemia. This study indicates that glucose-glucagon interactions may be important in regulation of glucagon secretion in sheep.
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Selected References
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