Abstract
A reevaluation of the disposition kinetics and extent of absorption of sulfadimethoxine in normal dogs following intravenous and oral dosage has been made. The tissue to plasma level ratio at the peak tissue level (k12/k21) was 0.55, while the tissue to plasma level ratio after distribution equilibrium (k12/k21-beta) was 0.926. The systemic availability of sulfadimethoxine from the oral suspension was 48.8% (24.4-86.2) when corrections for intrasubject variability were made.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baggot J. D., Ludden T. M., Powers T. E. The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs. Can J Comp Med. 1976 Jul;40(3):310–317. [PMC free article] [PubMed] [Google Scholar]