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. 1978 Jan;42(1):132–138.

Effect of prednisolone treatment on selected respiratory parameters and cardiac output in prematurely delivered neonatal lambs.

F N Thompson, M van Kampen, D H Culver
PMCID: PMC1277804  PMID: 647453

Abstract

Lambs were delivered by hysterotomy on days 142 and 143 postcoitum and were assigned to either a control group or a prednisolone-treated group (10 mg/kg daily for four days). On days 1 through 3 of life erythrocyte 2,3-diphosphoglycerate values were significantly increased in the treated group. Prednisolone treatment did not result in significantly increased P50 values. Mean plasma corticoid values in the control group decreased gradually postpartum. The prednisolone-treated lambs compared to the control lambs had depressed corticoid values, differing significantly on day 4. Body weight gains were significantly depressed by treatment and this effect lasted beyond the treatment period. On day 1 of life (24 hours postinitial treatment) oxygen consumption and cardiac output were significantly elevated in the treated group.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agar N. S. Postnatal changes in the levels of 2,3-diaphosphoglycerate, reduced glutathione and some enzyme activities in the erythrocytes of lambs. Res Vet Sci. 1976 Mar;20(2):223–224. [PubMed] [Google Scholar]
  2. Alexander D. P., Britton H. G., Cohen N. M., Nixon D. A. The permeability of the sheep placenta to insulin: studies with the perfused placental preparation. Biol Neonate. 1972;21(5):361–368. doi: 10.1159/000240524. [DOI] [PubMed] [Google Scholar]
  3. Alexander G., Williams D. Cardiovascular function in young lambs during summit metabolism. J Physiol. 1970 May;208(1):65–83. doi: 10.1113/jphysiol.1970.sp009106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baden M., Bauer C. R., Colle E., Klein G., Taeusch H. W., Jr, Stern L. A controlled trial of hydrocortisone therapy in infants with respiratory distress syndrome. Pediatrics. 1972 Oct;50(4):526–534. [PubMed] [Google Scholar]
  5. Bassett J. M., Alexander G. Insulin, growth hormone and corticosteroids in neonatal lambs. Normal concentrations and the effects of gold. Biol Neonate. 1971;17(1):112–125. doi: 10.1159/000240306. [DOI] [PubMed] [Google Scholar]
  6. Bellingham A. J., Detter J. C., Lenfant C. Regulatory mechanisms of hemoglobin oxygen affinity in acidosis and alkalosis. J Clin Invest. 1971 Mar;50(3):700–706. doi: 10.1172/JCI106540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Benesch R., Benesch R. E. The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem Biophys Res Commun. 1967 Jan 23;26(2):162–167. doi: 10.1016/0006-291x(67)90228-8. [DOI] [PubMed] [Google Scholar]
  8. GOETSCH D. D., McDONALD L. E. Glucocorticoid effects on respiration and metabolism by rat liver homogenates. Am J Physiol. 1962 Feb;202:343–346. doi: 10.1152/ajplegacy.1962.202.2.343. [DOI] [PubMed] [Google Scholar]
  9. Gorshein D., Oski F. A., Delivoria-Papadopoulos M. Effect of androgens on the red cell 2, 3 diphosphoglycerate hemoglobin oxygen affinity and red cell mass in mammals. Proc Soc Exp Biol Med. 1974 Dec;147(3):616–618. doi: 10.3181/00379727-147-38400. [DOI] [PubMed] [Google Scholar]
  10. Huisman T. H., Lewis J. P., Blunt M. H., Adams H. R., Miller A., Dozy A. M., Boyd E. M. Hemoglobin C in newborn sheep and goats: a possible explanation for its function and biosynthesis. Pediatr Res. 1969 May;3(3):189–198. doi: 10.1203/00006450-196905000-00001. [DOI] [PubMed] [Google Scholar]
  11. Liggins G. C., Howie R. N. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics. 1972 Oct;50(4):515–525. [PubMed] [Google Scholar]
  12. Loeb J. N. Corticosteroids and growth. N Engl J Med. 1976 Sep 2;295(10):547–552. doi: 10.1056/NEJM197609022951007. [DOI] [PubMed] [Google Scholar]
  13. McConn R., Del Guercio L. R. Respiratory function of blood in the acutely ill patient and the effect of steroids. Ann Surg. 1971 Sep;174(3):436–450. doi: 10.1097/00000658-197109000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mellor D. J., Mackay J. M., Williams J. T. Effects of oestrogen on activity and survival of lambs delivered by hysterectomy. Res Vet Sci. 1972 Jul;13(4):399–401. [PubMed] [Google Scholar]
  15. Murphy B. E. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967 Jul;27(7):973–990. doi: 10.1210/jcem-27-7-973. [DOI] [PubMed] [Google Scholar]
  16. Paisey R. B., Nathanielsz P. W. Plasma cortisol levels in the newborn lamb from birth to 30 days. J Endocrinol. 1971 Aug;50(4):701–702. doi: 10.1677/joe.0.0500701. [DOI] [PubMed] [Google Scholar]
  17. Platzker A. C., Kitterman J. A., Mescher E. J., Clements J. A., Tooley W. H. Surfactant in the lung and tracheal fluid of the fetal lamb and acceleration of its appearance by dexamethasone. Pediatrics. 1975 Oct;56(4):554–561. [PubMed] [Google Scholar]
  18. Rorth M. Hemoglobin interactions and red cell metabolism. Ser Haematol. 1972;5(1):1–104. [PubMed] [Google Scholar]
  19. Silken A. B. Pharmacologic manipulation of human erythrocyte 2,3-diphosphoglycerate levels by prednisone administration. Pediatr Res. 1975 Feb;9(2):61–64. doi: 10.1203/00006450-197502000-00001. [DOI] [PubMed] [Google Scholar]
  20. Taylor P., Hopkins L., Young M., McFadyen I. R. Ketamine anaesthesia in the pregnant sheep. Vet Rec. 1972 Jan 8;90(2):35–36. doi: 10.1136/vr.90.2.35. [DOI] [PubMed] [Google Scholar]
  21. Thompson F. N., Armstrong K., Kreuz S. S., Cornelius L. M. Effect of adrenalectomy in the dog on blood gas tensions and oxygen content. Am J Vet Res. 1977 Feb;38(2):235–239. [PubMed] [Google Scholar]
  22. Thompson F. N., Wagner W. C. Fetal-maternal corticosteroid relationships in sheep during late pregnancy. J Reprod Fertil. 1974 Nov;41(1):49–56. doi: 10.1530/jrf.0.0410049. [DOI] [PubMed] [Google Scholar]

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