Bioscience Reports has been made aware of potential issues surrounding the scientific validity of this paper and is hence issuing an Expression of Concern to notify readers whilst the Editorial Office investigates. Irregularities have been noted in the Western Blots of Figure 1B and C. Specifically, there are background details in Figure 1B that unexpectedly repeat, and a region of the CC column of Figure 1C that has a smudged appearance. The authors have been contacted for comment, and we have not yet received a response or the requested raw data.
. 2025 Oct 9;45(10):675. doi: 10.1042/BSR20160612_EOC
Expression of Concern: Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis
Guo-Dong Zhen
1, Lian-Bin Zhao
1, Shan-Shan Wu
1, Ming-Yu Chen
1, Zhen-He Li
1, Sheng-Zhi Zhou
1, Zhen-Fu Li
1
Guo-Dong Zhen
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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Lian-Bin Zhao
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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Shan-Shan Wu
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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Ming-Yu Chen
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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Zhen-He Li
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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Sheng-Zhi Zhou
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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Zhen-Fu Li
1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
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1Department of Emergency, Yishui Central Hospital of Linyi, Linyi 276400, Shandong Province, China
Collection date 2025 Oct.
© [year] The Author(s).
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
PMCID: PMC12784342 PMID: 41065331
This is an expression of concern about the following article: "Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis" in volume 37, BSR20160612.
