Correction: Ashadi et al. Reproductive Health 22, 236 (2025)
https://doi.org/10.1186/s12978-025–02180-1
In this article [1], Tables 3 and 4 appeared incorrectly and have now been corrected in the original publication. For completeness and transparency, the correct versions are displayed below:
Table 3.
Characteristics of studies on miscarriage factors (< 28 weeks)
| Author | Non-genetic factors | Number of primary studies | Number of cases/ controls |
Summary effect size based on random model (95%CI) | PI 95% | P-value random | The largest study | I2 |
P-value Egger test |
NOS |
|---|---|---|---|---|---|---|---|---|---|---|
| Diseases | ||||||||||
| [46] | Rheumatoid arthritis | 6 | - | 1/32(1/21–1/43) | - | 0/001 | - | 25/8% | - | 10 |
| [47] | Underweight | 9 |
20,512 168,691 |
1/08(0/98–1/20) | - | 0/170 | - | 54% | did not exist | 7 |
| [47] | Overweight | 7 |
25,618 87,644 |
1/07(1/02–1/12) | - | 0/010 | - | 41% | did not exist | 7 |
| [47] | Obesity | 7 |
11,934 87,644 |
1/15(1/08–1/23) | - | 0/0001 | - | 8% | did not exist | 7 |
| [47] | Obesity (Grade 1) | 3 |
2314 23,233 |
1/08(0/97–1/20) | - | 0/180 | - | 47% | did not exist | 7 |
| [47] | Obesity (Grade 2) | 3 |
1242 2333 |
1/50(1/32–1/70) | - | 0/0001 | - | 23% | did not exist | 7 |
| [48] | PCOs | 3 |
295 275 |
2/86(1/64–4/98) | Including the null value | 0/0001 | 3/00(1/39–6/46) | 0% | 0/123 | 9 |
| Medicines and treatments | ||||||||||
| [49] | Inhaled corticosteroid-s (anti-inflammatory and immunosuppressive medication) | 3 | - | 1/20(1/15–1/24) | 0/46–2/13 | 0/0001 | 1/20(1/20–1/30) | 0% | 0/428 | 8 |
| [49] | Systemic corticosteroids (anti-inflammatory and immunosuppressive drugs) | 2 | - | 1/41(0/86–2/32) | It could not be calculated | 0/163 | 1/70(1/10–2/50) | 36/8% | It could not be calculated | 8 |
| [50] | Endocervical versus decidual polypectomy | 2 |
64 92 |
0/26(0/04–1/58) | It could not be calculated | 0/145 | 0/58(0/07–4/89) | 18/4% | It could not be calculated | 11 |
| Behavioral factors | ||||||||||
| [51] | Smoking | 50 | - | 1/22(1/16–1/29) | 0/90–1/51 | 0/0001 | 1/13(1/05 0 1/22) | 58/4% | 0/010 | 9 |
| [51] | Second-hand smoke | 17 | - | 1/11(0/94–1/30) | 0/51–1/88 | 0/192 | 1/01(0/80–1/27) | 44/5% | 0/262 | 9 |
| [52] | pregnancy intention | 2 | - | 1/54(1/78–3/03) | It could not be calculated | 0/213 | 1/10(0/90–1/50) | 90% | It could not be calculated | 8 |
Table 4.
Characteristics of studies on miscarriage factors (definition of miscarriage is not mentioned in the study)
| Author | Non-genetic factors | Number of primary studies | Number of cases/ controls |
Summary effect size based on random model (95%CI) | PI 95% | P-value random | The largest study | I2 |
P-value Egger test |
NOS |
|---|---|---|---|---|---|---|---|---|---|---|
| Chemical biomarkers | ||||||||||
| [53] | Gamma-aminobutyric acid analog | 4 | - | 1/64(1/13–2/37) | 0/07–4/76 | 0/0001 | 1/90(1/10–3/40) | 0% | 0/762 | 9 |
| [54] | High serum β-human chorionic gonadotropin | 4 |
2558 46,876 |
2/88(1/76–4/68) | 0/042 − 7/08 | 0/0001 | 2/18(1/38–3/49) | 11/4% | 0/270 | 8 |
| [55] | hyperhomocysteinemia | 3 |
117 133 |
0/53(0/33–0/86) | Including the null value | 0/010 | 0/55(0/31–0/99) | 0% | 0/949 | 7 |
| [55] | Serum Vitamin B12 deficiency | 2 |
100 102 |
3/00(1/70–5/28) | It could not be calculated | 0/0001 | 2/55(1/43–4/61) | 9/3% | It could not be calculated | 7 |
| [55] | Folic acid deficiency | 4 |
683 1138 |
0/78(0/48–1/27) | 0/009 − 5/23 | 0/322 | 1/06(0/88–1/28) | 75% | 0/250 | 7 |
| [56] | Thyroid autoimmune antibodies | 10 |
1426 11,194 |
4/29(2/22–8/27) | 0/10–8/00 | 0/0001 | 6/11(3/96–9/38) | 87/6% | 0/264 | 7 |
| Semiconductor agents | ||||||||||
| [57] | fabrication | 6 | - | 1/26(1/03–1/55) | 0/40–2/38 | 0/020 | 0/94(0/58–1/50) | 6/9% | 0/210 | 11 |
| [57] | Photo-lithography work | 6 | - | 1/37(1/10–1/71) | 0/41–2/57 | 0/005 | 1/43(1/02 - 2/01) | 0% | 0/037 | 11 |
| [57] | Ethylene glycol ether | 4 | - | 1/42(0/94–2/16) | 0/03–5/13 | 0/090 | 1/43(1/02–2/01) | 53/5% | 0/145 | 11 |
| [57] |
Fluoride exposure |
2 | - | 1/19(0/73–1/95) | It could not be calculated | 0/472 | 1/14(0/66–1/99) | 0% | It could not be calculated | 11 |
| Environmental factors | ||||||||||
| [58] |
Particulate matter PM2.5 |
5 | - | 1/21(1/02–1/42) | 0/37–2/37 | 0/025 | 1/04(1/03–1/06) | 98/9% | 0/711 | 10 |
| [58] |
Particulate matter PM10 |
5 | - | 1/09(1/02–1/17) | 0/67–1/56 | 0/010 | 1/02(0/99–1/06) | 82/1% | 0/011 | 10 |
| [59] | Pesticides | 13 |
192,426 232,214 |
1/41(1/10–1/80) | 0/39–2/68 | 0/006 | 1/62(1/58–1/65) | 81/8% | 0/379 | 8 |
| [60] | Perfluoro-decanoate | 5 | - | 1/59(0/95–2/66) | 0/04–5/09 | 0/076 | 1/10(0/81–1/53) | 62/8% | 0/360 | 9 |
| [60] | Perfluoro-hexane sulfonate | 5 | - | 1/03(0/96–1/11) | 0/65–1/48 | 0/368 | 1/04(0/96–1/12) | 0% | 0/794 | 9 |
| [60] |
Perfluoro- nonanoate |
5 | - | 1/45(0/72–2/90) | 0/01–6/34 | 0/292 | 0/86(0/70–1/06) | 91/5% | 0/495 | 9 |
| [60] |
Perfluoro- Octanoate sulphonate |
9 | - | 1/00(0/88–1/12) | 0/54–1/60 | 0/999 | 0/95(0/87–1/04) | 34/1% | 0/086 | 9 |
| [60] |
Perfluoro- octane sulfonic acid |
9 | - | 1/06(0/94–1/21) | 0/55–1/69 | 0/317 | 0/99(0/94–1/05) | 43/7% | 0/283 | 9 |
| [61] | Antineoplastic agents | 9 | - | 1/56(1/16–2/09) | 0/30–3/18 | 0/003 | 1/16(0/99–1/35) | 78/2% | 0/289 | 10 |
| [62] | Exposure to dioxins in food | 2 |
837 1065 |
1/04(0/79–1/37) | It could not be calculated | 0/751 | 0/98(0/83–1/17) | 23/9% | It could not be calculated | 9 |
| Microbial, infectious agents and vaccination | ||||||||||
| [63] | Helicobacter pylori | 6 |
1159 4750 |
1/50(1/05–2/14) | 0/18–3/58 | 0/06 | 0/92(0/42–2/02) | 27/8% | 0/764 | 10 |
| [64] | Serum antibodies against Toxoplasma gondii | 11 |
2207 1717 |
3/98(2/03–7/77) | 0/15–7/24 | 0/0001 | 1/59(0/95–2/66) | 32/1% | 0/005 | 9 |
| [65] | Toxoplasma gondii IgG antibody | 19 |
4130 3159 |
2/21(1/54–3/18) | 0/28–4/25 | 0/0001 | 0/94(0/77–1/15) | 83/9% | 0/006 | 10 |
| [65] | Toxoplasma gondii IgM antibody | 19 |
4077 2740 |
4/33(2/42–7/76) | 0/19–7/42 | 0/0001 | 1/14(0/73–1/77) | 71/3% | 0/001 | 10 |
| [66] | HIV infection | 2 |
155 948 |
1/35(0/77– 2/35) | It could not be calculated | 0/29 | 1/58(0/74–3/37) | 0% | It could not be calculated | 8 |
| [67] | Oral cholera vaccine | 2 |
2147 1107 |
1/54(0/78–3/03) | It could not be calculated | 0/205 | 1/62(0/76–3/44) | 0% | It could not be calculated | 9 |
| [68] | HPV Vaccine | 7 |
52,503 3,280,744 |
0/98(0/85–1/13) | 0/43–1/78 | 0/852 | 0/94(0/87–1/02) | 68/1% | 0/724 | 11 |
| [69] | Neisseria gonorrhoeae | 3 | - | 2/11(0/50–8/92) | - | 0/307 | 0/86(0/56–1/33) | 72/9% | 0/075 | 10 |
| [70] | HPV | 3 |
124 386 |
0/99(0/37–2/64) | Including the null value | 0/990 | 1/80(0/99–3/30) | 66/1% | 0/701 | 10 |
| [71] | hepatitis B virus infection | 2 | - | 1/09(0/51–2/29) | It could not be calculated | 0/817 | 0/77(0/53–1/12) | 79/1% | It could not be calculated | 9 |
| [72] | hepatitis E virus infection | 3 |
274 309 |
1/71(0/79–3/69) | Including the null value | 0/169 | 1/49(0/46–4/78) | 1/3% | 0/080 | 10 |
| [73] | Genital mycoplasma | 19 |
1584 2020 |
2/35(1/50–3/67) | 0/19–4/83 | 0/0001 | 1/17(0/61–2/23) | 69/7% | 0/471 | 8 |
| [74] | Vaginal bacteria | 7 |
622 836 |
1/30(1/04–1/62) | 0/37–2/53 | 0/019 | 1/04(0/91–1/19) | 56/8% | 0/104 | 10 |
| [75] | Dengue infection | 5 | - | 1/90(0/95–3/78) | 0/02–6/33 | 0/067 | 0/78(0/29–2/11) | 17/5% | 0/244 | 9 |
| Diseases | ||||||||||
| [76] | Thyroid Cancer | 3 |
2373 9838 |
1/80(1/28–2/52) | 0/0002–10/53 | 0/001 | 2/07(1/58–2/72) | 32/9% | 0/056 | 9 |
| [77] | Breast Cancer | 2 | - | 1/04(0/86–1/26) | It could not be calculated | 0/696 | 1/05(0/86–1/27) | 0% | It could not be calculated | 9 |
| [78] | Gestational diabetes | 26 |
2166 24,032 |
3/01(2/38–3/82) | 0/76–4/38 | 0/0001 | 4/32(2/95–6/32) | 68/2% | 0/572 | 11 |
| [79] | Leiomyomas | 5 |
1394 20,435 |
0/86(0/72–1/03) | 0/28–1/97 | 0/107 | 0/83(0/63–1/08) | 0% | 0/128 | 10 |
| [80] | Hodgkin lymphoma | 2 | - | 0/78(0/55–1/10) | It could not be calculated | 0/160 | 0/80(0/50–1/29) | 0% | It could not be calculated | 9 |
| [81] | Non-Hodgkin lymphoma | 2 | - | 0/94(0/62–1/43) | It could not be calculated | 0/787 | 1/10(0/90–1/40) | 55/3% | It could not be calculated | 9 |
| [82] | Psoriasis | 4 | - | 1/62(0/99–2/63) | 0/01–6/10 | 0/050 | 1/10(1/00– 1/20) | 80/6% | 0/193 | 9 |
| [83] | Lyme disease | 3 | - | 1/27(0/42–3/85) | Including the null value | 0/668 | 2/14(0/50–9/09) | 0% | 0/147 | 10 |
| [84] | Uterine artery embolization | 3 |
244 253 |
0/86(0/72–1/03) | Including the null value | 0/290 | 1/40(0/66–2/97) | 0% | 0/963 | 10 |
| [85] | Uterine fibroids | 15 | - | 4/51(2/80–7/26) | - | 0/0001 | - | 51/3% | - | 10 |
| [86] | Primary biliary cholangitis | 4 |
596 1058 |
1/26(1/01–1/57) | 0/19–3/12 | 0/035 | 1/22(0/86–1/75) | 0% | 0/880 | 10 |
| [87] | Familial Mediterranean fever | 5 |
910 1030 |
0/94(0/71–1/24) | 0/16–2/67 | 0/693 | 0/93(0/63–1/36) | 89% | 0/17 | 10 |
| [88] | Sjögren’s syndrome | 4 |
343 902 |
9/35(4/18–20/91) | 0/007 − 16/47 | 0/0001 | 16/32(6/79–39/23) | 0% | 0/005 | 11 |
| [89] | Hyperandrogenic | 6 |
572 694 |
1/47(0/92–2/35) | 0/09–4/20 | 0/100 | 1/23(0/75–2/01) | 42/7% | 0/230 | 10 |
| [90] | Systemic lupus erythematosus | 3 |
4397 8,788,494 |
4/64(3/02–7/28) | Including the null value | 0/0001 | 4/85(4/26–5/51) | 66% | 0/944 | 10 |
| [91] | Depression | 2 | - | 1/88(1/50–2/35) | It could not be calculated | - | - | 0% | It could not be calculated | 10 |
| [91] | Anxiety | 2 | - | 1/25(1/11–1/40) | It could not be calculated | - | - | 0% | It could not be calculated | 10 |
| [92] | Non-alcoholic fatty liver | 2 |
1870 4614 |
1/15(1/02–1/30) | It could not be calculated | 0/02 | - | 0% | It could not be calculated | 9 |
| [93] | Epilepsy | 6 | - | 1/78(1/11–2/85) | - | - | - | 78/6% | - | 11 |
| [94] | Nausea and vomiting during pregnancy | 2 | - | 0/40(0/12–1/27) | It could not be calculated | 0/122 | 0/66(0/46–0/99) | 77/6% | It could not be calculated | 6 |
| [95] | Primary antiphospholipid syndrome | 3 |
190 287 |
2/47(1/11–5/47) | Including the null value | 0/025 | 2/58(1/40–4/74) | 36/9% | 0/679 | 8 |
| [96] | History of recurrent miscarriage | 2 |
595 989 |
6/37(3/83–10/57) | It could not be calculated | 0/0001 | 5/54(3/17–9/69) | 13/1% | It could not be calculated | 8 |
| [97] | Vaginal bleeding | 8 | - | 4/30(2/00–9/00) | - | - | - | 93% | - | 11 |
| [98] | Diabetes Mellitus | 13 |
110,872 7,266,388 |
1/23(1/13–1/33) | 0/8–1/65 | 0/0001 | 1/11(1/07–1/15) | 82/6% | 0/812 | 7 |
| [98] | T1DM | 7 |
4806 233,055 |
1/18(1/01–1/37) | 0/51–2/01 | 0/030 | 1/11(1/00–1/23) | 49/1% | 0/846 | 7 |
| [98] | T2DM | 6 | - | 1/08(1/04–1/12) | 0/79–1/38 | 0/0001 | 1/04(1/00–1/09) | 28/9% | 0/062 | 7 |
| [98] | Insulin-resistant diabetes mellitus | 3 |
27,484 263,731 |
1/43(1/22–1/68) | 0/019–5/71 | 0/0001 | 1/26(1/22–1/31) | 87/8% | 0/890 | 7 |
| [99] | Hyperthyroidism | 4 |
163 5278 |
2/11(0/23–18/85) | Including the null value | 0/501 | 0/22(0/05–0/89) | 78/6% | 0/709 | 10 |
| [100] | Family history of miscarriage | 2 |
338 3450 |
2/31(1/73–3/09) | It could not be calculated | 0/0001 | 2/52(1/74–3/66) | 0% | It could not be calculated | 10 |
| [101] | Celiac disease | 7 |
7978 78,241 |
1/34(1/10–1/65) | 0/43–2/45 | 0/004 | 1/05(0/98–1/13) | 62/6% | 0/006 | 10 |
| Medicines and treatments | ||||||||||
| [102] | Itraconazole | 3 |
536 929 |
1/43(0/37–5/45) | Including the null value | 0/594 | 1/44(0/15–13/58) | 0% | 0/428 | 9 |
| [103] | Pregravid OCP | 4 |
23,295 76,441 |
0/62(0/41–0/96) | 0/011–4/57 | 0/032 | 0/97(0/90–1/05) | 92/4% | 0/203 | 9 |
| [104] | Ondansetron | 13 |
188,200 3,936,991 |
0/52(0/31–0/89) | 0/025–3/53 | 0/017 | 0/82(0/64–1/05) | 92/1% | 0/634 | 9 |
| [105] | Preconcep-tion care for women with diabetes | 11 |
869 1836 |
0/86(0/70–1/06) | - | - | - | - | - | 11 |
| [106] | Proton pump inhibitors | 3 | - | 0/85(0/70–1/90) | - | - | - | 0% | - | 10 |
| [107] | Nonsteroidal anti-inflammatory drug | 11 | - | 1/19(0/92–1/54) | 0/46–3/43 | 0/163 | 1/10(0/99–1/22) | 91/6% | 0/54 | 10 |
| [108] | Levothyroxine in autoimmunity | 5 | - | 0/12(0/07–0/19) | - | 0/0001 | - | 62% | - | 9 |
| [109] | Treating Chronic Hepatitis B Infection | - | - | 0/47(0/11–1/92) | - | 0/290 | - | 31% | - | 9 |
| [110] | Benzodiazepines in the treatment of anxiety | 5 | - | 1/85(1/42–2/42) | 0/29–3/68 | 0/0001 | 1/40(1/26–1/57) | 76/5% | 0/174 | 10 |
| [111] |
Amino Acid Salicylic Acid in IBD |
5 | - | 1/14(0/65–2/01) | - | 0/738 | - | - | - | 8 |
| [112] | Triptans in the treatment of migraine and cluster headaches | 2 |
178 50,865 |
3/54(2/24–5/59) | It could not be calculated | 0/0001 | 3/64(2/22–5/99) | 0% | It could not be calculated | 10 |
| [113] | enoxaparin and aspirin verses aspirin for thromboembolism and thromboprophylaxis during pregnancy | 2 | - | 0/53(0/12–2/23) | It could not be calculated | 0/392 | 0/38(0/26– 0/56) | 34% | It could not be calculated | 10 |
| [114] | Topical retinoids | 3 |
430 945 |
1/01(0/63–1/62) | Including the null value | 0/937 | 1/41(0/77–2/61) | 7/7% | 0/156 | 9 |
| [115] | Antipsychotics | 4 |
1306 2482 |
1/05(0/61–1/81) | 0/007–6/03 | 0/856 | 0/81(0/59– 1/11) | 70% | 0/741 | 9 |
| [76] | Radiotherapy for thyroid cancer | 6 |
6078 7270 |
1/07(0/99–1/16) | 0/69–1/50 | 0/065 | 1/07(0/98–1/16) | 0% | 0/304 | 9 |
| [116] | Colchine in the treatment of familial Mediterranean fever | 4 |
590 1575 |
0/64(0/45–0/92) | 0/03–3/65 | 0/003 | 0/57(0/33–0/99) | 0% | 0/897 | 9 |
| [117] | Hemodialysis | 2 | - | 0/38(0/12–1/23) | It could not be calculated | - | - | 0% | It could not be calculated | 9 |
| [118] | Infliximab versus adalimumab in inflammatory bowel disease patients | 5 |
193 97 |
0/60(0/17–2/09) | 0/00024–8/42 | 0/429 | 0/32(0/03–4/01) | 0% | 0/727 | 11 |
| [119] | surgical therapies for inflammatory bowel disease | 5 |
246 530 |
2/02(1/13–3/60) | 0/05–5/68 | 0/016 | 1/20(0/54–2/67) | 8/4% | 0/317 | 10 |
| [120] |
Hyperthyroidism Treatment (Propylthiouracil vs. Methimazole) |
4 |
1734 1654 |
0/89(0/71–1/12) | 0/13–2/81 | 0/336 | 0/90(0/71–1/13) | 0% | 0/592 | 9 |
| [121] | Amniocentesis | 6 | - | 1/59(0/98–2/59) | - | 0/06 | - | - | - | 10 |
| [121] | Chorionic villus sampling | 2 | - | 1/61(0/36–7/26) | It could not be calculated | 0/50 | - | - | It could not be calculated | 10 |
| [122] | Cervical cerclage | 6 |
904 622 |
0/42(0/28–0/63) | - | 0/0001 | - | 71% | - | 10 |
| [123] | Long-acting insulin compared to intermediate-acting basal insulin | 2 | - | 1/26(0/85–1/87) | It could not be calculated | 0/233 | 1/25(0/84–1/86) | 0% | It could not be calculated | 9 |
| [124] | Insulin lispro vs. regular | 3 | - | 0/76(0/19–3/02) | - | - | - | - | - | 8 |
| [125] | Laser treatment in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome | 4 | - | 1/56(1/28–1/91) | 0/28–3/24 | 0/0001 | 1/44(1/05–2/00) | 0% | 0/355 | 10 |
| [126] | Laparoscopy vs. laparotomy in removal of uterine adnexal mass | 11 |
299 504 |
1/53(0/66–3/54) | 0/03–5/25 | 0/311 | 1/75(0/33–1/15) | 0% | 0/153 | 9 |
| [127] | Poor HbA1C control versus optimal control | 4 | - | 3/23(1/64–6/36) | 0/0089–8/99 | 0/001 | 5/44(2/23–12/45) | 28/2% | 0/713 | 8 |
| [128] | Histamine H2 Blockers in the Treatment of Gastroesophageal Reflux | 2 |
738 1575 |
0/62(0/36–1/05) | It could not be calculated | - | - | - | It could not be calculated | 9 |
| [129] | Metformin in the treatment of polycystic ovary syndrome | 4 |
326 454 |
0/19(0/12–0/31) | 0/003–4/19 | 0/001 | 0/23(0/11–0/48) | 0% | 0/365 | 8 |
| [130] | Hydroxychloroquine in the treatment of autoimmune diseases | 4 |
363 707 |
1/85(1/10–3/14) | 0/02–6/33 | 0/021 | 2/29(1/13–4/65) | 12/4 | 0/436 | 9 |
| [131] | hysteroscopic septum resection | 7 |
258 184 |
0/25(0/07–0/88) | Including the null value | 0/03 | 1/67(0/94–2/97) | 81% | 0/007 | 9 |
| [132] | Radiation therapy during childhood | 2 |
648 1247 |
1/20(0/83–1/73) | It could not be calculated | 0/335 | 1/44(0/99–2/09) | 45/6% | It could not be calculated | 10 |
| Trace elements | ||||||||||
| [133] | Cadmium | 8 |
361 398 |
7/95(2/23–28/33) | 0/004–15/40 | 0/001 | 2/23(1/40–3/93) | 93/8% | 0/115 | 9 |
| [133] | Lead | 15 |
765 1218 |
14/04(4/95–39/76) | 0/032–20/10 | 0/0001 | 2/33(1/53–3/52) | 96% | 0/001 | 9 |
| [133] | Copper | 14 |
655 2108 |
0/07(0/02–0/19) | 0/0001–6/35 | 0/0001 | 0/63(0/39–1/01) | 95/4% | 0/011 | 9 |
| [133] | Zinc | 14 |
673 2000 |
0/14(0/04–0/51) | Including the null value | 0/003 | 0/22(0/13–0/36) | 96/9% | 0/309 | 9 |
| Behavioral and emotional factors | ||||||||||
| [134] | IUD removal | - | - | 0/51(0/39–0/66) | - | 0/0001 | - | 85% | 8 | |
| [135] | cocaine use /drug free controls | 2 | - | 5/32(0/22–125/9) | It could not be calculated | - | - | - | It could not be calculated | 5 |
| [135] | cocaine polydrug users /drug free controls | 2 | - | 10/56(1/74–64/1) | It could not be calculated | - | - | - | It could not be calculated | 5 |
| [135] | cocaine polydrug users /polydrug no cocaine controls | 2 | - | 3/50(0/64–19/2) | It could not be calculated | - | - | - | It could not be calculated | 5 |
| [136] | Adverse childhood experiences | 3 | - | 1/82(1/47–2/85) | - | 0/001 | - | 0% | did not exist | 10 |
| [137] | intimate partner violence | 9 | - | 2/03(1/25–3/31) | - | - | - | - | - | 9 |
| [137] | Sexual violence in childhood | 6 | - | 1/35(0/75–2/44) | - | - | - | - | - | 9 |
| [138] | Breastfeeding | 3 |
595 1324 |
0/88(0/33–2/34) | Including the null value | 0/805 | 0/46(0/22–0/95) | 63/7% | 0/281 | 10 |
| [139] | Pregnancy interval 6 to 11 months | 2 | - | 1/00(0/80–1/24) | It could not be calculated | - | - | 0% | It could not be calculated | 9 |
| Menstrual disorders | ||||||||||
| [140] | Short menstrual cycle | 3 | - | 1/86(1/10–3/14) | Including the null value | 0/020 | 1/74(0/88–3/44) | 0% | 0/782 | 11 |
| [140] | Long menstrual cycles | 4 | - | 1/88(1/02–3/47) | 0/008–7/32 | 0/042 | 0/99(0/53–1/85) | 43% | 0/050 | 11 |
| Occupational factors | ||||||||||
| [141] | Rotating shifts vs. daily shifts | 14 | - | 1/04(0/84–1/29) | 0/34–2/15 | 0/664 | 0/82(0/68–0/99) | 63/8% | 0/534 | 11 |
| [141] | Working more than 40 h | 5 | - | 1/72(1/27–2/34) | 0/25–3/62 | 0/0001 | 1/80(1/02–3/19) | 0% | 0/491 | 11 |
| [141] | Working the night shift | 12 | - | 1/23(1/03–1/46) | 0/52–2/07 | 0/021 | 1/32(1/04–1/68) | 33/2% | 0/507 | 11 |
| [142] | Anesthetic gases | 16 |
11,623 33,146 |
1/26(0/98–1/63) | 0/29–2/70 | 0/068 | 0/85(0/71–1/01) | 88/4% | 0/735 | 9 |
| [142] | Chemotherapy agents | 6 |
2529 4866 |
1/20(0/79–1/83) | 0/10–3/62 | 0/371 | 1/31(0/75–2/28) | 32/4% | 0/138 | 9 |
| [143] | Exposure to noise | 5 | - | 1/07(0/99–1/16) | 0/63–1/58 | 0/087 | 1/10(1/00–1/20) | 28/4% | 0/874 | 8 |
| [144] | Hairdresser | 7 |
5413 1173 |
1/28(1/11–1/47) | 0/39–2/46 | 0/0001 | 1/31(1/07–1/60) | 0% | 0/312 | 8 |
| Nutritional factors | ||||||||||
| [145] | Coffee consumption | 4 |
1143 2460 |
2/76(1/64–4/64) | 0/02–7/50 | 0/0001 | 3/98(2/55–6/21) | 63/8% | 0/655 | 9 |
| [145] | Caffeine consumption | 11 |
3341 10,202 |
2/38(1/76–3/23) | 0/47–3/98 | 0/0001 | 2/21(1/53–3/19) | 63% | 0/110 | 9 |
| [146] | Fruit consumption | 3 | - | 0/46(0/24–0/87) | Including the null value | 0/017 | 0/30(0/20–0/30) | 86/7% | 0/585 | 11 |
| [146] | Vegetable consumption | 3 | - | 0/58(0/45–0/75) | 0/001–6/94 | 0/0001 | 0/60(0/40–0/80) | 0% | 0/535 | 11 |
| [146] | Fruit and vegetable consumption | 3 | - | 0/81(0/43–1/53) | Including the null value | 0/530 | 0/49(0/36–0/66) | 79/7% | 0/154 | 11 |
| [146] | Meat consumption | 2 | - | 0/84(0/44–1/61) | It could not be calculated | 0/608 | 1/10(0/90–1/30) | 74/4% | It could not be calculated | 11 |
| [146] | Red meat consumption | 3 | - | 0/99(0/84–1/18) | 0/01–5/22 | 0/994 | 0/98(0/81–1/18) | 0% | 0/984 | 11 |
| [146] | White meat consumption | 2 | - | 0/80(0/64–0/99) | It could not be calculated | 0/046 | 0/82(0/65–1/02) | 0% | It could not be calculated | 11 |
| [146] | Seafood consumption | 4 | - | 0/81(0/67–0/98) | 0/15–2/48 | 0/036 | 0/86(0/71–1/03) | 35/7% | 0/736 | 11 |
| [146] | Dairy consumption | 5 | - | 0/65(0/51–0/82) | 0/13–2/22 | 0/0001 | 0/60(0/50–0/80) | 44/8% | 0/426 | 11 |
| [146] | Egg consumption | 3 | - | 0/85(0/62–1/15) | 0/0002–9/06 | 0/307 | 0/70(0/60–0/80) | 79/7% | 0/743 | 11 |
| [146] | Fat and oil consumption | 2 | - | 1/07(0/49–2/31) | It could not be calculated | 0/858 | 0/73(0/54–0/99) | 90/4% | It could not be calculated | 11 |
| [146] | Sugar consumption | 2 | - | 2/36(0/37–14/88) | It could not be calculated | 0/361 | 1/10(0/87–1/40) | 78/8 5 | It could not be calculated | 11 |
| [146] | Cereal consumption | 2 | - | 0/70(0/44–1/09) | It could not be calculated | 0/118 | 0/57(0/41–0/79) | 63/5% | It could not be calculated | 11 |
| Serum platelets | ||||||||||
| [147] | Average platelet volume | 18 |
2168 1985 |
1/38(0/61–3/15) | 0/009–6/37 | 0/433 | 1/43(1/07–1/91) | 97/1% | 0/682 | 10 |
| [147] | Platelet distribution width | 13 |
2100 2611 |
6/42(2/50–16/11) | 0/03–11/77 | 0/0001 | 1/40(1/10–1/76) | 98/2% | 0/978 | 10 |
The original article has been corrected.
References
- 1.Arshadi M, Lotfi MH, Madadizadeh F, et al. Non-genetic risk factors of miscarriage: a comprehensive umbrella review of systematic review and meta-analysis. Reprod Health. 2025;22:236. [DOI] [PMC free article] [PubMed] [Google Scholar]
