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. 1979 Jul;292:421–428. doi: 10.1113/jphysiol.1979.sp012861

Plasma active and inactive renin in the rabbit: effect of dietary sodium depletion and repletion.

S A Grace, K A Munday, A R Noble, H K Richards
PMCID: PMC1280868  PMID: 490374

Abstract

1. Active and acid-activatable (inactive) renins were measured in rabbit plasma under control conditions and during sodium depletion with subsequent repletion. 2. Active renin increased by 97% during sodium depletion and returned to control levels on repletion. Both changes were complete within 1 day of changing the diet. 3. During dietary sodium depletion inactive renin levels initially fell to zero and then increased until, after 13 days, inactive renin was again 10% of total renin levels, a proportion comparable to the control values. 4. Sodium repletion caused plasma inactive renin to return to control levels over about 13 days, a quite different time course to active renin. Therefore, in the first phase of repletion the proportion of total renin in the inactive form rose to 19%. 5. These changes are discussed in relation to concurrent changes in sodium, potassium and water metabolism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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