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. 1979 Jun;291:1–9. doi: 10.1113/jphysiol.1979.sp012794

Endogenous prostaglandins and stimulated gastric secretion in the cat: the effect of various secretory inhibitors.

R Baker, B M Jaffe, J D Reed, B Shaw, C W Venables
PMCID: PMC1280882  PMID: 383948

Abstract

1. The effects of cimetidine, somatostatin and atropine upon the outputs of acid, pepsin, prostaglandins (PG) E and F in gastric juice secreted in response to i.v. infusions of pentagastrin and histamine (H) have been studied in the conscious gastric fistula cat. 2. At constant rate infusions secretion of PGE occurs and follows a similar pattern to that of gastric acid. However the ratio of H:PGE varies considerably and to an extent inexplicable in terms of assay variation. 3. Inhibition of acid output is matched by inhibition of the output of PGE, but changes in concentration of PGE suggest this is a volume related phenomenon. 4. It is concluded that gastric juice PGE is most unlikely to have a regulatory effect upon acid secretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker R., Jaffe B. M., Reed J. D., Shaw B., Venables C. W. Endogenous prostaglandins and gastric secretion in the cat. J Physiol. 1978 May;278:451–460. doi: 10.1113/jphysiol.1978.sp012316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carter D. C., Karim S. M., Bhana D., Ganesan P. A. Inhibition of human gastric secretion by prostaglandin. Br J Surg. 1973 Oct;60(10):828–831. doi: 10.1002/bjs.1800601018. [DOI] [PubMed] [Google Scholar]
  3. Chiang L., Sanchez-Chiang L., Wolf S., Tang J. The separate determination of human pepsin and gastricsin. Proc Soc Exp Biol Med. 1966 Jul;122(3):700–704. doi: 10.3181/00379727-122-31231. [DOI] [PubMed] [Google Scholar]
  4. Coceani F., Pace-Asciak C., Volta F., Wolfe L. S. Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Am J Physiol. 1967 Oct;213(4):1056–1064. doi: 10.1152/ajplegacy.1967.213.4.1056. [DOI] [PubMed] [Google Scholar]
  5. Horton E. W. Hypotheses on physiological roles of prostaglandins. Physiol Rev. 1969 Jan;49(1):122–161. doi: 10.1152/physrev.1969.49.1.122. [DOI] [PubMed] [Google Scholar]
  6. Jaffe B. M., Behrman H. R., Parker C. W. Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. J Clin Invest. 1973 Feb;52(2):398–405. doi: 10.1172/JCI107196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jaffe B. M., Smith J. W., Newton W. T., Parker C. W. Radioimmunoassay for prostaglandins. Science. 1971 Feb 5;171(3970):494–496. doi: 10.1126/science.171.3970.494. [DOI] [PubMed] [Google Scholar]
  8. Nezamis J. E., Robert A., Stowe D. F. Inhibition by prostaglandin E 1 of gastric secretion in the dog. J Physiol. 1971 Oct;218(2):369–383. doi: 10.1113/jphysiol.1971.sp009623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pace-Asciak C. Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds. Biochim Biophys Acta. 1972 Sep 7;280(1):161–171. doi: 10.1016/0005-2760(72)90221-4. [DOI] [PubMed] [Google Scholar]
  10. Pace-Asciak C., Wolfe L. S. Biosynthesis of prostaglandins E2 and F2-alpha from tritium-labelled arachidonic acid by rat stomach homogenates. Biochim Biophys Acta. 1970 Dec 15;218(3):539–542. doi: 10.1016/0005-2760(70)90017-2. [DOI] [PubMed] [Google Scholar]
  11. Ramwell P. W., Shaw J. E. Prostaglandin inhibition of gastric secretion. J Physiol. 1968 Mar;195(2):34P–36P. [PubMed] [Google Scholar]

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