Skip to main content
NCBI home page
Biophysical Journal logoLink to Biophysical Journal
. 1990 Jul;58(1):267–271. doi: 10.1016/S0006-3495(90)82372-9

Stroboscopic nuclear magnetic resonance microscopy of arterial blood flow.

R W Behling 1, H K Tubbs 1, M D Cockman 1, L W Jelinski 1
PMCID: PMC1280959  PMID: 2383635

Abstract

NMR microscopy was used to obtain transverse flow profiles of arterial blood flow in the rat carotid artery at 33 microns resolution. The images were gated to the EKG and correspond to identified regions of diastole. The profiles show that flow is laminar during this part of the heart cycle. These results provide the first direct view of blood flow profiles in arteries of submillimeter diameter and suggest that animals as small as juvenile rodents will serve as valuable models for hemodynamic studies. Extensions to flow during systole, stenoses, and flow in the vicinity of the carotid bifurcation are discussed.

Full text

PDF
267

Images in this article

268FIGURE 1
on p.268
269FIGURE 2
on p.269

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman J. J., Ewy C. S., Becker N. N., Shalwitz R. A. Deuterium nuclear magnetic resonance measurements of blood flow and tissue perfusion employing 2H2O as a freely diffusible tracer. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4099–4102. doi: 10.1073/pnas.84.12.4099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Behling R. W., Tubbs H. K., Cockman M. D., Jelinski L. W. Stroboscopic NMR microscopy of the carotid artery. Nature. 1989 Sep 28;341(6240):321–323. doi: 10.1038/341321a0. [DOI] [PubMed] [Google Scholar]
  3. Bottomley P. A., Rogers H. H., Foster T. H. NMR imaging shows water distribution and transport in plant root systems in situ. Proc Natl Acad Sci U S A. 1986 Jan;83(1):87–89. doi: 10.1073/pnas.83.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kim S. G., Ackerman J. J. Multicompartment analysis of blood flow and tissue perfusion employing D2O as a freely diffusible tracer: a novel deuterium NMR technique demonstrated via application with murine RIF-1 tumors. Magn Reson Med. 1988 Dec;8(4):410–426. doi: 10.1002/mrm.1910080405. [DOI] [PubMed] [Google Scholar]
  5. Pettigrew R. I., Dannels W., Galloway J. R., Pearson T., Millikan W., Henderson J. M., Peterson J., Bernardino M. E. Quantitative phase-flow MR imaging in dogs by using standard sequences: comparison with in vivo flow-meter measurements. AJR Am J Roentgenol. 1987 Feb;148(2):411–414. doi: 10.2214/ajr.148.2.411. [DOI] [PubMed] [Google Scholar]
  6. Rittgers S. E., Fei D. Y., Kraft K. A., Fatouros P. P., Kishore P. R. Velocity profiles in stenosed tube models using magnetic resonance imaging. J Biomech Eng. 1988 Aug;110(3):180–184. doi: 10.1115/1.3108428. [DOI] [PubMed] [Google Scholar]
  7. Walker M. F., Souza S. P., Dumoulin C. L. Quantitative flow measurement in phase contrast MR angiography. J Comput Assist Tomogr. 1988 Mar-Apr;12(2):304–313. doi: 10.1097/00004728-198803000-00021. [DOI] [PubMed] [Google Scholar]
  8. Wedeen V. J., Meuli R. A., Edelman R. R., Geller S. C., Frank L. R., Brady T. J., Rosen B. R. Projective imaging of pulsatile flow with magnetic resonance. Science. 1985 Nov 22;230(4728):946–948. doi: 10.1126/science.4059917. [DOI] [PubMed] [Google Scholar]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

RESOURCES