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. 1979 Mar;288:437–447.

Evidence for primary afferent depolarization of single tooth-pulp afferents in the cat.

S J Lisney
PMCID: PMC1281437  PMID: 469728

Abstract

1. Responses of single tooth-pulp afferents to electrical stimulation of sites in the trigeminal sensory nuclear complex were recorded from caine teeth in cats. 2. Changes in the excitability of the central terminals of a pulpal afferent after stimulation of other groups of sensory nerves were taken as evidence for changes in their polarization. 3. Electrical stimulation of nerves in other teeth resulted in raised excitability of the central terminals of pulpal afferents lasting up to 300 msec. The greatest effects were observed 30--100 msec after the conditioning stimulus. 4. Increased terminal excitability was also observed after the ipsilateral infraorbital nerve was stimulated. This occurred when only nerve fibres with conduction velocities in the A alpha range were excited. 5. Mechanical stimulation of a canine tooth produced increases in terminal excitability of pulpal afferents innervating the same tooth. 6. A similar effect was also observed after a brief pull on a group of ipsilateral mystacial vibrissae. 7. No evidence of decreases in the excitability of the central terminals of tooth-pulp afferents was obtained with any of the conditioning stimuli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DARIAN-SMITH I. PRESYNAPTIC COMPONENT IN THE AFFERENT INHIBITION OBSERVED WITHIN TRIGEMINAL BRAIN-STEM NUCLEI OF THE CAT. J Neurophysiol. 1965 Jul;28:695–709. doi: 10.1152/jn.1965.28.4.695. [DOI] [PubMed] [Google Scholar]
  2. Davies W. I., Scott D., Jr, Vesterstrom K., Vyklický L. Depolarization of the tooth pulp afferent terminals in the brain stem of the cat. J Physiol. 1971 Nov;218(3):515–532. doi: 10.1113/jphysiol.1971.sp009631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Greenwood F., Horiuchi H., Matthews B. Electrophysiological evidence on the types of nerve fibres excited by electrical stimulation of teeth with a pulp tester. Arch Oral Biol. 1972 Apr;17(4):701–709. doi: 10.1016/0003-9969(72)90196-3. [DOI] [PubMed] [Google Scholar]
  4. Greenwood L. F., Sessle B. J. Inputs to trigeminal brain stem neurones from facial, oral, tooth pulp and pharyngolaryngeal tissues: II. Role of trigeminal nucleus caudalis in modulating responses to innocuous and noxious stimuli. Brain Res. 1976 Nov 26;117(2):227–238. doi: 10.1016/0006-8993(76)90732-0. [DOI] [PubMed] [Google Scholar]
  5. Jänig W., Schmidt R. F., Zimmermann M. Two specific feedback pathways to the central afferent terminals of phasic and tonic mechanoreceptors. Exp Brain Res. 1968;6(2):116–129. doi: 10.1007/BF00239166. [DOI] [PubMed] [Google Scholar]
  6. Kawamura Y., Nishiyama T. Projection of dental afferent impulses to the trigeminal nuclei of the cat. Jpn J Physiol. 1966 Oct 15;16(5):584–597. doi: 10.2170/jjphysiol.16.584. [DOI] [PubMed] [Google Scholar]
  7. Khayyat G. F., Yu U. J., King R. B. Response patterns to noxious and non-noxious stimuli in rostral trigeminal relay nuclei. Brain Res. 1975 Oct 24;97(1):47–60. doi: 10.1016/0006-8993(75)90913-0. [DOI] [PubMed] [Google Scholar]
  8. Lisney S. J. Evidence for primary afferent depolarization of tooth pulp afferents following stimulation of other trigeminal afferents in the cat [proceedings]. J Physiol. 1978 Sep;282:12P–13P. [PubMed] [Google Scholar]
  9. Lisney S. J., Matthews B. Branched afferent nerves supplying tooth-pulp in the cat. J Physiol. 1978 Jun;279:509–517. doi: 10.1113/jphysiol.1978.sp012359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lisney S. J. Some anatomical and electrophysiological properties of tooth-pulp afferents in the cat. J Physiol. 1978 Nov;284:19–36. doi: 10.1113/jphysiol.1978.sp012525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Matthews B. Responses of intradental nerves to electrical and thermal stimulation of teeth in dogs. J Physiol. 1977 Jan;264(3):641–664. doi: 10.1113/jphysiol.1977.sp011687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nord S. G. Bilateral projection of the canine tooth pulp to bulbar trigeminal neurons. Brain Res. 1976 Sep 3;113(3):517–525. doi: 10.1016/0006-8993(76)90053-6. [DOI] [PubMed] [Google Scholar]
  13. Nord S. G., Young R. F. Projection of tooth pulp afferents to the cat trigeminal nucleus caudalis. Brain Res. 1975 Jun 13;90(2):195–204. doi: 10.1016/0006-8993(75)90301-7. [DOI] [PubMed] [Google Scholar]
  14. Schmidt R. F. Presynaptic inhibition in the vertebrate central nervous system. Ergeb Physiol. 1971;63:20–101. doi: 10.1007/BFb0047741. [DOI] [PubMed] [Google Scholar]
  15. Sessle B. J., Greenwood L. F. Inputs to trigeminal brain stem neurones from facial, oral, tooth pulp and pharyngolaryngeal tissues: I. Responses to innocuous and noxious stimuli. Brain Res. 1976 Nov 26;117(2):211–226. doi: 10.1016/0006-8993(76)90731-9. [DOI] [PubMed] [Google Scholar]
  16. WAGERS P. W., SMITH C. M. Responses in dental nerves of dogs to tooth stimulation and the effects of systemically administered procaine, lidocaine and morphine. J Pharmacol Exp Ther. 1960 Sep;130:89–105. [PubMed] [Google Scholar]
  17. WALL P. D. Excitability changes in afferent fibre terminations and their relation to slow potentials. J Physiol. 1958 Jun 18;142(1):1–21. doi: 10.1113/jphysiol.1958.sp005997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Whitehorn D., Burgess P. R. Changes in polarization of central branches of myelinated mechanoreceptor and nociceptor fibers during noxious and innocuous stimulation of the skin. J Neurophysiol. 1973 Mar;36(2):226–237. doi: 10.1152/jn.1973.36.2.226. [DOI] [PubMed] [Google Scholar]
  19. Willis W. D., Núnez R., Rudomín P. Excitability changes of terminal arborizations of single Ia and Ib afferent fibers produced by muscle and cutaneous conditioning volleys. J Neurophysiol. 1976 Nov;39(6):1150–1159. doi: 10.1152/jn.1976.39.6.1150. [DOI] [PubMed] [Google Scholar]
  20. Yokota T. Two types of tooth pulp units in the bulbar lateral reticular formation. Brain Res. 1976 Mar 12;104(2):325–329. doi: 10.1016/0006-8993(76)90626-0. [DOI] [PubMed] [Google Scholar]
  21. Young R. F., Nord S. G. Experimental modulation of medullary dental pulp units by mechanical stimulation of oro-facial fields. Exp Neurol. 1975 Dec;49(3):813–821. doi: 10.1016/0014-4886(75)90061-8. [DOI] [PubMed] [Google Scholar]
  22. Young R. F. Response properties of neurons in trigeminal nucleus caudalis to noxious and innocuous stimuli under chloralose anesthesia. Exp Neurol. 1978 Feb;58(3):521–534. doi: 10.1016/0014-4886(78)90106-1. [DOI] [PubMed] [Google Scholar]
  23. Yu Y. J., King R. B. Trigeminal main sensory nucleus polymodal unit responses to noxious and non-noxious stimuli. Brain Res. 1974 May 31;72(1):147–152. doi: 10.1016/0006-8993(74)90658-1. [DOI] [PubMed] [Google Scholar]

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