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. 1995 Mar;68(3):795–799. doi: 10.1016/S0006-3495(95)80255-9

Membrane potential and input resistance are ambiguous measures of sealing of transected cable-like structures.

T L Krause 1, Y Magarshak 1, H M Fishman 1, G D Bittner 1
PMCID: PMC1281803  PMID: 7756546

Abstract

For many years, membrane potential (Vm) and input resistance have been used to characterize the electrophysiological nature of a seal (barrier) that forms at the cut end of a transected axon or other extended cytoplasmic structure. Data from a mathematical and an analog model of a transected axon and other theoretical considerations show that steady-state values of Vm and input resistance measured from any cable-like structure provide a very equivocal assessment of the electrical barrier (seal) at the cut end. Extracellular assessments of injury currents almost certainly provide a better electrophysiological measure of the status of plasma membrane sealing because measurements of these currents do not depend on the cable properties of extended cytoplasmic processes after transection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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