Abstract
Externally applied nonuniform electric fields can strongly affect thermodynamic phases in a lipid monolayer when applied under conditions of temperature, pressure, and composition that are near phase boundaries. Under such conditions nonuniform applied fields can produce or suppress phase separations. Field-induced phase-separated domains have sizes that are in good agreement with calculations. Field gradients can also produce large concentration gradients in binary mixtures just above their critical points. The present work elaborates our earlier studies of these field effects using thermodynamic models of the phase behavior of two-component liquid mixtures. The calculations are of interest in connection with biological membranes that, at the growth temperature, are in a liquid state close to a phase boundary.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Behan-Martin M. K., Jones G. R., Bowler K., Cossins A. R. A near perfect temperature adaptation of bilayer order in vertebrate brain membranes. Biochim Biophys Acta. 1993 Sep 19;1151(2):216–222. doi: 10.1016/0005-2736(93)90106-a. [DOI] [PubMed] [Google Scholar]
- Lee K. Y., Klingler J. F., McConnell H. M. Electric field-induced concentration gradients in lipid monolayers. Science. 1994 Feb 4;263(5147):655–658. doi: 10.1126/science.8303272. [DOI] [PubMed] [Google Scholar]
- Linden C. D., Wright K. L., McConnell H. M., Fox C. F. Lateral phase separations in membrane lipids and the mechanism of sugar transport in Escherichia coli. Proc Natl Acad Sci U S A. 1973 Aug;70(8):2271–2275. doi: 10.1073/pnas.70.8.2271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Möhwald H. Phospholipid and phospholipid-protein monolayers at the air/water interface. Annu Rev Phys Chem. 1990;41:441–476. doi: 10.1146/annurev.pc.41.100190.002301. [DOI] [PubMed] [Google Scholar]
- Recktenwald D. J., McConnell H. M. Phase equilibria in binary mixtures of phosphatidylcholine and cholesterol. Biochemistry. 1981 Jul 21;20(15):4505–4510. doi: 10.1021/bi00518a042. [DOI] [PubMed] [Google Scholar]
- Rice P. A., McConnell H. M. Critical shape transitions of monolayer lipid domains. Proc Natl Acad Sci U S A. 1989 Sep;86(17):6445–6448. doi: 10.1073/pnas.86.17.6445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seul M, Sammon MJ. Competing interactions and domain-shape instabilities in a monomolecular film at an air-water interface. Phys Rev Lett. 1990 Apr 16;64(16):1903–1906. doi: 10.1103/PhysRevLett.64.1903. [DOI] [PubMed] [Google Scholar]
- Vist M. R., Davis J. H. Phase equilibria of cholesterol/dipalmitoylphosphatidylcholine mixtures: 2H nuclear magnetic resonance and differential scanning calorimetry. Biochemistry. 1990 Jan 16;29(2):451–464. doi: 10.1021/bi00454a021. [DOI] [PubMed] [Google Scholar]