Retraction Note: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

Retraction Note: Nature Communications 10.1038/s41467-018-05812-2, published online 17 August 2018

The Editors have retracted this article. After publication, concerns were raised regarding some of the images presented in the figures, specifically:

• Fig. 2b Ad-LacZ ECKO and 7f Ad-LacZ R2-SUMO1 images appear to overlap;

• Fig. 2b Ad-VEGF WT and 7f WT Empty vector Ad-VEGF and STZ R2-WT Ad-VEGF images appear to overlap;

• Fig. 2b Ad-VEGF ECKO and 7f Ad-VEGF R2-SUMO1 images appear to overlap (rotated 180 degrees);

• Fig. 3g SENP1 blot appears highly similar to Fig. 7c VEGFR2 in the authors’ earlier study¹;

• Fig. 5e siSENP1/R2-SUMO1 0 h and siSENP1/R2-KR 0 h images appear to overlap;

• Fig. 7f STZ Empty vector Ad-VEGF and R2-SUMO1 Ad-VEGF images appear to overlap.

Further issues have been identified in the uncut blots provided in the supplementary materials.

Due to the high number of concerns, the Editors no longer have confidence in the presented data.

Huanjiao Jenny Zhou and Wang Min do not agree with this retraction. None of the other authors have responded to any correspondence from the publisher about this retraction.