Correction to: Journal of Clinical Immunology (2023) 43:1827–1839
https://doi.org/10.1007/s10875-023-01551-2
Table 1 carried an erratum. The reference numbers were incorrect.
Table 1.
Patient characteristics and transplant procedure in XLA patients
| Patient | Age (At the diagnosis) | Variant of BTK (gene, protein) | Age (At HCT) | Indication | Neurological complication | IBD | Infectious complication at HCT | CLD | Donor source | HLA matching (genotype) | Donor | Conditioning regimen (dose, days) | MAC, RTC, or RIC | GVHD prophylaxis | NCC 108/kg | CD34 106/kg |
Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | NA | 5 | Bacterial infection | None | None | Infection of the right lower limb, Chronic nasosinusitis | None | BM | 10/10 | Sibling | BU 12 mg/kg, CY 6.0 g/m2, CD3 McAb 6 mg/kg | MAC | CsA, sMTX | 4.6 | NA | [9] |
| 2 | 5 | A to G variant (AAAGGGGAACTA to AAAGGGAGCTG) at position − 29 in the BTK promoter | 14 | AML | None | None | None | None | PBSC | 10/10 | Unrelated donor | TBI 12 Gy, CY 120 mg/kg, ETP 40 mg/kg | MAC | Tac, sMTX | - | 10.4 | [10] |
| 3 | NA | NA | 28 | Bacterial infection | Meningitis | None | None | None | PBSC | 6/6 | Sibling | Flu 180 mg/m2, CY 100 mg/kg, TBI 3 Gy, ATG (T) 2.5 mg/kg | RIC | CsA, MMF | 6.7 | 4.8 | [13 |
| 4 | 2 | c.1908 + 1G > C | 24 | ALL (MRD+) | None | None | None | +* | PBSC | 6/6 | Sibling | TBI 13.2 Gy, ETP (Data of dose is none) | MAC | CsA, sMTX | - | 5.0 | [17 |
| 5 | 0.7 | NA | 1.4 | Bacterial infection | None | None | Pneumonia, Gastroenteritis | None | BM | 6/6 | Sibling | TT 8 mg/kg, Treo 28 g/m2, Flu 160 mg/m2 | RT-MAC | Tac, sMTX | - | 7.0 | [16, 18] |
| 6 | 1 | Exon 3 to 5 deletion | 1.7 | Bacterial infection | None | None | Pneumonia | None | BM | 6/6 | Sibling | BU 12.8 mg/kg, Flu 160 mg/m2 | RIC | Tac, sMTX | - | NA | [16, 18] |
| 6-re | 2 | PBSC | 6/6 | Sibling | TT 8 mg/kg, Treo 28 g/m2, Flu 160 mg/m2 | RT-MAC | Tac, sMTX | - | 6.5 | [16, 18] | |||||||
| 7 | 1.5 | c.777–3 C > G | 9 | Bacterial infection | Meningoencephalitis | None | Pneumonia, Diarrhea, Otitis media | None | PBSC | 5/10 | NA | Treo, Flu (Data of dose is NA) | RIC | PTCY, Tac | - | 5.5 | - |
| 8 | 1 | NA | 6 | Bacterial infection | None | None | Pneumonia, Gastroenteritis | None | PBSC | 6/6 | Sibling | TT, Treo, Flu (Data of dose is NA) | RT-MAC | Tac, sMTX | - | 6.8 | - |
| 9 | 3 | c.1815_1819delinsTCACTGAACACATTGCCCAAG, p.E605Dfs*3 | 4 | Bacterial infection | None | None | +* | None | PBSC | 9/10 | Unrelated donor | BU 12 mg/kg, Flu 150 mg/m2, Ara-C 3 g/m2, CY 50 mg/kg, ATG (T) 6 mg/kg | RIC | PTCY, CsA, sMTX | 25.5 | 8.9 | [15] |
| 10 | 23 | c.1902G > C, p.W634C | 24 | Lymphoma | None | + | +* | +* | PBSC | 5/10 | Haploidentical related donor | BU 12.8 mg/kg, Flu 200 mg/m2, CY 50 mg/kg, ATG (T) 10 mg/kg | RIC | PTCY, CsA, sMTX | 16.4 | 7.4 | [15] |
| 11 | 0.7 | c.1750 + 2T > C | 8 | Norovirus infection | None | None | Norovirus enteropathy | None | PBSC | 12/12 | Unrelated donor | TT 10 mg/kg, Treo 42 g/m2, Flu 150 mg/m2, ALZ 0.5 mg/kg | RT-MAC | CsA, MMF | 11.7 | 9.0 | [8] |
| 12 | 0.1 | IVS10 -5 T > G | 11 | SCD | None | None | None | None | BM | 10/10 | Father | BU AUC 63 mg*h/ml, TT 10 mg/kg, Flu 150 mg/m2, ATG (G) 45 mg/kg | RT-MAC | CsA, MMF | 2.9 | 2.4 | - |
| 13 | 0.7 | с.763 C > T, p.R255* | 10 | Crohn’s disease | None | + | None | None | PBSC | 9/10 | NA | Treo 42 g/m2, Flu 150 mg/m2, ATG (T) 5 mg/kg, RTX 100 mg/m2 | RIC | TCRαβ depletion, Tac, sMTX | 6.7 | 7.1 | [14] |
| 14 | 3 | c82C > T, p.R28C | 14 | Aichi virus infection | None | None | Aichi virus infections (Liver and kidney failure, Obstructive pancreatitis) | None | PBSC | 10/10 | Sibling | Treo 42 g/m2, Flu 150 mg/m2 | RIC | CsA, MMF | - | 5.0 | [11] |
| 15 | 0.5 | NA | 14 | Bacterial infection | NA | NA | NA | NA | UCB | 5/6 | Unrelated donor | BU 12 mg/kg, CY 200 mg/kg, CD3 McAb 50 mg | MAC | CsA, sMTX, MMF | 0.42 | 3.5 | [12] |
| 16 | 2 | BTK expression absent (Protein) | 25 |
Bacterial infection (IBD, CLD) |
None | + | Chronic Haemophilus influenzae infection of eye, Persistent COVID-19, Giardia in GI tract | Left lobectomy | PBSC | 12/12 | NA | Treo 42 g/m2, Fludarabine 150 mg/m2, TT 10 mg/kg, ALZ 1 mg/kg | RT-MAC | CsA, MMF | 5.6 | 3.2 | - |
| 17 | 5 | c.43 C > T, p.Gln15Ter | 22 | Norovirus infection | None | None | Chronic norovirus infection, Severe GI and GU fistula, Recurrent UTI | None | PBSC | 10/10 | Unrelated donor | Treo 42 g/m2, Fludarabine 150 mg/m2, TT 10 mg/kg, ALZ 1 mg/kg | RT-MAC | CsA, MMF | 6.6 | 6.5 | - |
| 18 | 0.8 | NA | 3 | Bacterial infection | None | None | Pneumonia, Gastroenteritis | None | PBSC | 5/10 | Haploidentical paternal donor | TT, Treo, Flu, rATG (Data of dose is NA) | RT-MAC | TCRαβ depletion | - | 15 | - |
| 19 | 1 | c.1816 C > T, p.Arg562Trp | 18 | Aichi virus infection | None | None |
Disseminated Aichi infection (Severe renal damage) |
None | PBSC | NA | Haploidentical maternal donor | Treo 42 g/m2, Flu 160 mg/m2, TT 10 mg/kg, ATG (G) 45 mg/kg | RT-MAC | TCRαβ depletion | 5 | 45 | [19] |
| 20 | 6 | c.1750 + 5G > A | 42 | CD8 T-cell LPD | None | None | None | + | PBSC | 10/10 | NA | Me 140 mg/m2, Flu 120 mg/m2, TT 10 mg/kg, ATG (G) 30 mg/kg | RT-MAC | CsA, MMF | 5.8 | 5.0 | - |
| 21 | 4 | NA | 6 | Bacterial infection | None | None | Pneumonia, GI infection | None | PBSC | 5/10 | NA | Treo, Flu, ATG (T) (Data of dose is NA) | RIC | PTCY, Siro, MMF | NA | 11 | - |
| 22 | 13 | c.-31 + 1G > A | 13 | Aichi virus infection | None | None | Nodular regenerative hyperplasia and chronic hepatitis | None | PBSC | NA | Haploidentical paternal donor | TT, Treo, Flu (Data of dose is NA), ALZ 1 mg/kg | RT-MAC | TCRαβ depletion | 7.5 | 9.7 | - |
| 22-re | 13 | PBSC | NA | Haploidentical maternal donor | Flu, ATG (Data of dose is NA) | RIC | NA | NA | NA | - |
IBD Inflammatory bowel disease, LPD Lymphoproliferative disease, HCT Hematopoietic cell transplantation, CLD Chronic lung disease, GVHD Graft-versus-host disease, NCC Nucleated cell count, AML Acute myeloid leukemia, ALL Acute lymphoblastic leukemia, MRD Minimal residual disease, SCD Sickle cell disease, BM: Bone marrow, PBSC: Peripheral blood stem cell, UCB Umbilical cord blood, BU Busulfan, CY Cyclophosphamide, McAb Monoclonal antibody, TBI Total body irradiation, ETP Etoposide, ATG Anti-thymocyte globulin (T Thymoglobuline, G Grafalon), Flu Fludarabine, Treo Treosulfan, TT Thiotepa, Ara-C Cytarabine, RTX Rituximab, MAC Myeloablative conditioning, RTC Reduced toxicity conditioning, CsA Cyclosporin, sMTX Short-term methotrexate, MMF Mycophenolate mofetil, PTCY Post-transplant cyclophosphamide, Siro Sirolimus, GI Gastrointestinal, GU Genitourinary, UTI Urinary tract infection, NA Not available, *No detailed informationa
The corrected table is on the next page.
The original version has been corrected.
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