Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1978 Jan;274:9–16. doi: 10.1113/jphysiol.1978.sp012130

Glucose transport by brush-border membrane vesicles after proximal resection or ileo-jejunal transposition in the rat.

H Menge, H Murer, J W Robinson
PMCID: PMC1282473  PMID: 625015

Abstract

1. The functional properties of the ileal mucosa following jejunal resection or interposition in the jejunum were studied with the help of membrane vesicles. 2. Despite the development of functional and morphological features in the mucosa which are more generally associated with the jejunum than with the ileum, examination of brush-border vesicles derived from ileal and jejunal enterocytes from resected or transposed intestines reveals that the functional characteristics of apical membranes isolated from the different regions of the intestine are maintained after these surgical manoeuvres. Vesicles from control ileum develop an 'overshoot' uptake of glucose that is 3-4 times smaller than that of jejunal vesicles, a difference that is still observed in membranes prepared from mucosa of ileal loops following proximal resection or interposition in the jejunum.

Full text

PDF
9

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dowling R. H., Gleeson M. H. Cell turnover following small bowel resection and by-pass. Digestion. 1973;8(2):176–190. doi: 10.1159/000197312. [DOI] [PubMed] [Google Scholar]
  2. Grönqvist B., Engström B., Grimelius L. Morphological studies of the rat small intestine after jejuno-ileal transposition. Acta Chir Scand. 1975;141(3):208–217. [PubMed] [Google Scholar]
  3. Hanson W. R., Osborne J. W. Epithelial cell kinetics in the small intestine of the rat 60 days after resection of 70 per cent of the ileum and jejunum. Gastroenterology. 1971 Jun;60(6):1087–1097. [PubMed] [Google Scholar]
  4. Hopfer U. Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2027–2031. doi: 10.1073/pnas.72.6.2027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hopfer U., Sigrist-Nelson K., Groseclose R. Jejunal and ileal D-glucose transport in isolated brush border membranes. Biochim Biophys Acta. 1976 Mar 5;426(2):349–353. doi: 10.1016/0005-2736(76)90344-8. [DOI] [PubMed] [Google Scholar]
  6. Menge H., Gräfe M., Lorenz-Meyer H., Riecken E. O. The influence of food intake on the development of structural and functional adaptation following ileal resection in the rat. Gut. 1975 Jun;16(6):468–472. doi: 10.1136/gut.16.6.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Menge H., Robinson J. W., Mirkovitch V. Morphologie und Funktion der Dünndarmschleimhaut nach proximaler Dünndarmresektion unterschiedlicher Ausdehnung. Helv Chir Acta. 1976 Dec;43(5-6):755–757. [PubMed] [Google Scholar]
  8. Menge H., Robinson J. W., Riecken E. O. Anpassungsmöglichkeiten der Dünndarmschleimhaut an verschiedene intraluminale Milieuveränderungen. Z Gastroenterol. 1976 May;14(3):420–433. [PubMed] [Google Scholar]
  9. Murer H., Ammann E., Biber J., Hopfer U. The surface membrane of the small intestinal epithelial cell. I. Localization of adenyl cyclase. Biochim Biophys Acta. 1976 May 21;433(3):509–519. doi: 10.1016/0005-2736(76)90277-7. [DOI] [PubMed] [Google Scholar]
  10. Murer H., Hopfer U. Demonstration of electrogenic Na+-dependent D-glucose transport in intestinal brush border membranes. Proc Natl Acad Sci U S A. 1974 Feb;71(2):484–488. doi: 10.1073/pnas.71.2.484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Robinson J. W., Menge H., Sepúlveda F. V., Mirkovitch V. Functional and structural characteristics of the jejunum and ileum in the dog and the rat. Digestion. 1977;15(3):188–199. doi: 10.1159/000198003. [DOI] [PubMed] [Google Scholar]
  12. Schmitz J., Preiser H., Maestracci D., Ghosh B. K., Cerda J. J., Crane R. K. Purification of the human intestinal brush border membrane. Biochim Biophys Acta. 1973 Sep 27;323(1):98–112. doi: 10.1016/0005-2736(73)90434-3. [DOI] [PubMed] [Google Scholar]
  13. Sigrist-Nelson K., Murer H., Hopfer U. Active alanine transport in isolated brush border membranes. J Biol Chem. 1975 Jul 25;250(14):5674–5680. [PubMed] [Google Scholar]
  14. Tilson D., Clifford B. A glucose-stimulated nonelectrogenic sodium pump in ileal remnants after jejunectomy. J Surg Res. 1975 Apr;18(4):405–408. doi: 10.1016/0022-4804(75)90101-8. [DOI] [PubMed] [Google Scholar]
  15. Weser E., Hernandez M. H. Studies of small bowel adaptation after intestinal resection in the rat. Gastroenterology. 1971 Jan;60(1):69–75. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES