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. 1978 Jan;274:323–328. doi: 10.1113/jphysiol.1978.sp012150

Lability of renal papillary tissue composition in the rat.

J C Atherton
PMCID: PMC1282493  PMID: 624997

Abstract

1. The acute effects of (a) a minor operative procedure using ether as the anaesthetic, and (b) the administration of 0.9% saline as a single I.V. injection in the conscious rat, on renal tissue composition were studied in hydropenic and normally hydrated rats. 2. The operative procedure and anaesthesia induced a rapid and transient decrease in papillary osmolality in both hydropenic and normally hydrated animals, the important contributing factor being a significant decrease in urea content. 3. Administration of a small volume of saline caused a rapid decrease in urea content, and an increase in water content. 4. It is concluded that papillary composition is extremely labile, large changes being produced by relatively minor experimental procedures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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