Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1978 Oct;283:439–456. doi: 10.1113/jphysiol.1978.sp012511

Microvascular pressures and filtration coefficients in the cat mesentery.

P A Fraser, L H Smaje, A Verrinder
PMCID: PMC1282788  PMID: 722585

Abstract

1. Filtration coefficient and hydrostatic pressure have been measured in single capillaries and venules in the cat mesentery using a modification of the Landis (1927) single vessel occlusion technique. 2. Venules were found to be filtering fluid, not absorbing it as is often supposed. 3. The mean filtration coefficient in capillaries was 0.018 micrometers . s-1 . mmHg-1 (1.35 X 10(-10)m . s-1 . Pa-1) while that in venules, was 0.027 micrometers . s-1 . mmHg-1 (2.02 X 10(-10)m . s-1 . Pa-1). 4. In both capillaries and venules, filtration coefficient increased with decreasing pressure. 5. The difference between directly measured venular pressure and that calculated from the occlusion data was used to determine the contribution of the interstitium to fluid exchange. In the mesentery superfused with Krebs solution the tissue pressure so determined was found to be zero or subatmospheric initially but became increasingly positive with lengthening exposure of the mesentery.

Full text

PDF
439

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLOCH E. H. A quantitative study of the hemodynamics in the living microvascular system. Am J Anat. 1962 Mar;110:125–153. doi: 10.1002/aja.1001100204. [DOI] [PubMed] [Google Scholar]
  2. Blake T. R., Schneyer G. P. On the occluded capillary. Microvasc Res. 1974 May;7(3):362–375. doi: 10.1016/0026-2862(74)90023-5. [DOI] [PubMed] [Google Scholar]
  3. CREESE R., D'SILVA J. L., SHAW D. M. Interfibre fluid from guinea-pig muscle. J Physiol. 1962 Jun;162:44–53. doi: 10.1113/jphysiol.1962.sp006913. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clough G., Smaje L. H. Simultaneous measurement of pressure in the interstitium and the terminal lymphatics of the cat mesentery. J Physiol. 1978 Oct;283:457–468. doi: 10.1113/jphysiol.1978.sp012512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davies R. W., Gamble J. Changes in the rate of transudation of vascular fluid in the isolated rat mesentery following irradiation [proceedings]. J Physiol. 1977 Mar;266(1):71P–72P. [PubMed] [Google Scholar]
  6. Intaglietta M. Evidence for a gradient of permeability in frog mesenteric capillaries. Bibl Anat. 1967;9:465–468. [PubMed] [Google Scholar]
  7. Intaglietta M., Pawula R. F., Tompkins W. R. Pressure measurements in the mammalian microvasculature. Microvasc Res. 1970 Apr;2(2):212–220. doi: 10.1016/0026-2862(70)90009-9. [DOI] [PubMed] [Google Scholar]
  8. Lee J. S., Smaje L. H., Zweifach B. W. Fluid movement in occluded single capillaries of rabbit omentum. Circ Res. 1971 Mar;28(3):358–370. doi: 10.1161/01.res.28.3.358. [DOI] [PubMed] [Google Scholar]
  9. Levick J. R., Michel C. C. A densitometric method for determining the filtration coefficients of single capillaries in the frog mesentery. Microvasc Res. 1977 Mar;13(2):141–151. doi: 10.1016/0026-2862(77)90081-4. [DOI] [PubMed] [Google Scholar]
  10. Levick J. R., Michel C. C. The effects of position and skin temperature on the capillary pressures in the fingers and toes. J Physiol. 1978 Jan;274:97–109. doi: 10.1113/jphysiol.1978.sp012136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Levick J. R., Michel C. C. The permeability of individually perfused frog mesenteric capillaries to T1824 and T1824-albumin as evidence for a large pore system. Q J Exp Physiol Cogn Med Sci. 1973 Jan;58(1):67–85. doi: 10.1113/expphysiol.1973.sp002192. [DOI] [PubMed] [Google Scholar]
  12. MELLANDER S., OBERG B., ODELRAM H. VASCULAR ADJUSTMENTS TO INCREASED TRANSMURAL PRESSURE IN CAT AND MAN WITH SPECIAL REFERENCE TO SHIFTS IN CAPILLARY FLUID TRANSFER. Acta Physiol Scand. 1964 May-Jun;61:34–48. doi: 10.1111/j.1748-1716.1964.tb02940.x. [DOI] [PubMed] [Google Scholar]
  13. Michel C. C., Mason J. C., Curry F. E., Tooke J. E., Hunter P. J. A development of the Landis technique for measuring the filtration coefficient of individual capillaries in the frog mesentery. Q J Exp Physiol Cogn Med Sci. 1974 Oct;59(4):283–309. doi: 10.1113/expphysiol.1974.sp002275. [DOI] [PubMed] [Google Scholar]
  14. RENKIN E. M., ZAUN B. D. Effects of adrenal hormones on capillary permeability in perfused rat tissues. Am J Physiol. 1955 Mar;180(3):498–502. doi: 10.1152/ajplegacy.1955.180.3.498. [DOI] [PubMed] [Google Scholar]
  15. Simionescu M., Simionescu N., Palade G. E. Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature. J Cell Biol. 1975 Dec;67(3):863–885. doi: 10.1083/jcb.67.3.863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Skalak R., Branemark P. I. Deformation of red blood cells in capillaries. Science. 1969 May 9;164(3880):717–719. doi: 10.1126/science.164.3880.717. [DOI] [PubMed] [Google Scholar]
  17. Smaje L., Zweifach B. W., Intaglietta M. Micropressures and capillary filtration coefficients in single vessels of the cremaster muscle of the rat. Microvasc Res. 1970 Jan;2(1):96–110. doi: 10.1016/0026-2862(70)90055-5. [DOI] [PubMed] [Google Scholar]
  18. Starling E. H. On the Absorption of Fluids from the Connective Tissue Spaces. J Physiol. 1896 May 5;19(4):312–326. doi: 10.1113/jphysiol.1896.sp000596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. WIEDERHIELM C. A., WOODBURY J. W., KIRK S., RUSHMER R. F. PULSATILE PRESSURES IN THE MICROCIRCULATION OF FROG'S MESENTERY. Am J Physiol. 1964 Jul;207:173–176. doi: 10.1152/ajplegacy.1964.207.1.173. [DOI] [PubMed] [Google Scholar]
  20. Zewifach B. W., Intaglietta M. Measurement of blood plasma colloid osmotic pressure. II. Comparative study of different species. Microvasc Res. 1971 Jan;3(1):83–88. doi: 10.1016/0026-2862(71)90009-4. [DOI] [PubMed] [Google Scholar]
  21. Zweifach B. W., Prather J. W. Micromanipulation of pressure in terminal lymphatics in the mesentery. Am J Physiol. 1975 May;228(5):1326–1335. doi: 10.1152/ajplegacy.1975.228.5.1326. [DOI] [PubMed] [Google Scholar]
  22. Zweifach B. W. Quantitative studies of microcirculatory structure and function. I. Analysis of pressure distribution in the terminal vascular bed in cat mesentery. Circ Res. 1974 Jun;34(6):843–857. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES