Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1980 Jun;303:315–323. doi: 10.1113/jphysiol.1980.sp013287

The action of somatostatin on neurones of the myenteric plexus of the guinea-pig ileum.

Y Katayama, R A North
PMCID: PMC1282893  PMID: 6107380

Abstract

1. Intracellular recordings were made from neurones in ganglia of the myenteric plexus of the guinea-pig ileum. 2. Somatostatin (10-300 nM) was applied to the neurones by adding it to the perfusing solution or by ejecting it (charges up to 500 nC) from an ionophoresis electrode onto the soma membrane. 3. By both methods of application, somatostatin either hyperpolarized or depolarized a proportion of neurones. Depolarizing responses were more often observed with ionophoretic application, and hyperpolarizing responses were more often observed with application by perfusion. Both responses were preserved in solutions containing zero Ca and elevated (6 mM) Mg. Some cells were both hyperpolarized and depolarized, depending on the method of administration. 4. The depolarizing responses to somatostatin were associated with an increase in cell input resistance; they became larger with membrane depolarization and smaller with membrane hyperpolarization, and reversed in polarity at a potential close to the potassium equilibrium potential. The hyperpolarizing responses to somatostatin were accompanied by a fall in cell input resistance.

Full text

PDF
315

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen M. L., Rosing E., Wiley K. S., Slater I. H. Somatostatin inhibits adrenergic and cholinergic neurotransmission in smooth muscle. Life Sci. 1978 Oct 23;23(16):1659–1664. doi: 10.1016/0024-3205(78)90463-0. [DOI] [PubMed] [Google Scholar]
  2. Dodd J., Kelly S. Is somatostatin an excitatory transmitter in the hippocampus? Nature. 1978 Jun 22;273(5664):674–675. doi: 10.1038/273674a0. [DOI] [PubMed] [Google Scholar]
  3. Furness J. B., Costa M. Actions of somatostatin on excitatory and inhibitory nerves in the intestine. Eur J Pharmacol. 1979 Jun;56(1-2):69–74. doi: 10.1016/0014-2999(79)90434-5. [DOI] [PubMed] [Google Scholar]
  4. Guillemin R. Somatostatin inhibits the release of acetylcholine induced electrically in the myenteric plexus. Endocrinology. 1976 Dec;99(6):1653–1654. doi: 10.1210/endo-99-6-1653. [DOI] [PubMed] [Google Scholar]
  5. Hirst G. D., Holman M. E., Spence I. Two types of neurones in the myenteric plexus of duodenum in the guinea-pig. J Physiol. 1974 Jan;236(2):303–326. doi: 10.1113/jphysiol.1974.sp010436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hökfelt T., Johansson O., Efendic S., Luft R., Arimura A. Are there somatostatin-containing nerves in the rat gut? Immunohistochemical evidence for a new type of peripheral nerves. Experientia. 1975 Jul 15;31(7):852–854. doi: 10.1007/BF01938502. [DOI] [PubMed] [Google Scholar]
  7. Ioffe S., Havlicek V., Friesen H., Chernick V. Effect of somatostatin (SRIF) and L-glutamate on neurons of the sensorimotor cortex in awake habituated rabbits. Brain Res. 1978 Sep 22;153(2):414–418. doi: 10.1016/0006-8993(78)90425-0. [DOI] [PubMed] [Google Scholar]
  8. Johnson S. M., Katayama Y., North R. A. Slow synaptic potentials in neurones of the myenteric plexus. J Physiol. 1980 Apr;301:505–516. doi: 10.1113/jphysiol.1980.sp013220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Katayama Y., North R. A., Williams J. T. The action of substance P on neurons of the myenteric plexus of the guinea-pig small intestine. Proc R Soc Lond B Biol Sci. 1979 Nov 30;206(1163):191–208. doi: 10.1098/rspb.1979.0101. [DOI] [PubMed] [Google Scholar]
  10. Nishi S., North R. A. Intracellular recording from the myenteric plexus of the guinea-pig ileum. J Physiol. 1973 Jun;231(3):471–491. doi: 10.1113/jphysiol.1973.sp010244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. North R. A., Katayama Y., Williams J. T. On the mechanism and site of action of enkephalin on single myenteric neurons. Brain Res. 1979 Apr 6;165(1):67–77. doi: 10.1016/0006-8993(79)90045-3. [DOI] [PubMed] [Google Scholar]
  12. North R. A., Tonini M. The mechanism of action of narcotic analgesics in the guinea-pig ileum. Br J Pharmacol. 1977 Dec;61(4):541–549. doi: 10.1111/j.1476-5381.1977.tb07546.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Renaud L. P., Martin J. B., Brazeau P. Depressant action of TRH, LH-RH and somatostatin on activity of central neurones. Nature. 1975 May 15;255(5505):233–235. doi: 10.1038/255233a0. [DOI] [PubMed] [Google Scholar]
  14. Williams J. T., North R. A. Inhibition of firing of myenteric neurones by somatostatin. Brain Res. 1978 Oct 20;155(1):165–168. doi: 10.1016/0006-8993(78)90319-0. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES