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. 1980 Jul;304:51–57. doi: 10.1113/jphysiol.1980.sp013309

Contrasting roles of 5-hydroxytryptamine and noradrenaline in fever in rats.

D M Ford, K P Klugman
PMCID: PMC1282915  PMID: 6449591

Abstract

1. We have investigated the effects of endogenous monoamine depletion on the development of fever in rats. 2. Fever was produced in rats by a single intraperitoneal injection of Salmonella typhosa endotoxin or leucocyte pyrogen manufactured from ox blood. 3. Depletion of brain 5-hydroxytryptamine (5-HT) by pretreatment with p-chlorophenylalanine prevented the rise in rectal temperature produced both by bacterial endotoxin and by leucocyte pyrogen. 4. On the other hand depletion of noradrenaline (NA) by 6-hydroxydopamine pretreatment resulted in a potentiation of the fever produced by bacterial endotoxin. 5. These results suggest that 5-HT is involved in mechanisms responsible for the rise in temperature during fever and that NA is involved in mechanisms which serve to attenuate the rise.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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