Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1977 Apr;266(3):567–586. doi: 10.1113/jphysiol.1977.sp011782

Effects of steady-state plasma vasopressin levels on the distribution of intrarenal blood flow on electrolyte excretion.

N Akatsuka, W H Moran, M L Morgan, M F Wilson
PMCID: PMC1283580  PMID: 864614

Abstract

1. In order to evaluate the effects of arginine vasopressin (AVP) on the distribution of intrarenal blood flow and on electrolyte excretion, steady-state plasma AVP levels (4-8, 19-1, 44-3, and 100-6 micro u./ml.) were produced in anaesthetized dogs, which were hydrated to minimize endogenous anti-diuretic hormone (ADH) release. 2. The urinary excretion of sodium and potassium increased without change in their filtered loads during AVP infusion. 3. Measurement by the 133xenon washout method revealed diphasic blood flow shifts, as a function of the plasma AVP level, between compartment 1 (outer cortex) and compartment 2 (inner cortex and outer medulla) without change in compartment 3 (inner medulla). 4. In a separate study, the radioactive microsphere (15 micronm) method was used with a plasma AVP levels of 19-8 micronu./ml. Blood flow (expressed as % flow/g tissue) decreased in the outer cortex and increased in the inner cortex. 5. Total renal blood flow did not change during infusion of AVP. However, the values measured by 133xenon were lower than those measured by the microsphere method. 6. There was agreement between these two independent methods that blood flow shifted from outer to inner cortex, with no change in total renal flow, at similar plasma AVP levels (19-1 and 19-8 micronu./ml.). The relationship of these intrarenal circulatory changes to the increased electrolyte excretion is discussed.

Full text

PDF
567

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen A. M., Ladefoged J. Partition coefficient of 133-xenon between various tissues and blood in vivo. Scand J Clin Lab Invest. 1967;19(1):72–78. doi: 10.3109/00365516709093483. [DOI] [PubMed] [Google Scholar]
  2. Antoniou L. D., Burke T. J., Robinson R. R., Clapp J. R. Vasopressin-related alterations of sodium reabsorption in the loop of Henle. Kidney Int. 1973 Jan;3(1):6–13. doi: 10.1038/ki.1973.2. [DOI] [PubMed] [Google Scholar]
  3. Atherton J. C., Green R., Thomas S. Influence of lysine-vasopressin dosage on the time course of changes in renal tissue and urinary composition in the conscious rat. J Physiol. 1971 Mar;213(2):291–309. doi: 10.1113/jphysiol.1971.sp009383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Attallah A. A., Lee J. B. Radioimmunoassay of prostaglandin A. Intrarenal PGA2 as a factor mediating saline-induced natriuresis. Circ Res. 1973 Dec;33(6):696–703. doi: 10.1161/01.res.33.6.696. [DOI] [PubMed] [Google Scholar]
  5. BARTELSTONE H. J., NASMYTH P. A. VASOPRESSIN POTENTIATION OF CATECHOLAMINE ACTIONS IN DOG, RAT, CAT, AND RAT AORTIC STRIP. Am J Physiol. 1965 Apr;208:754–762. doi: 10.1152/ajplegacy.1965.208.4.754. [DOI] [PubMed] [Google Scholar]
  6. Bartter F. C., Schwartz W. B. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967 May;42(5):790–806. doi: 10.1016/0002-9343(67)90096-4. [DOI] [PubMed] [Google Scholar]
  7. Beeuwkes R., 3rd, Bonventre J. V. Tubular organization and vascular-tubular relations in the dog kidney. Am J Physiol. 1975 Sep;229(3):695–713. doi: 10.1152/ajplegacy.1975.229.3.695. [DOI] [PubMed] [Google Scholar]
  8. Blantz R. C., Katz M. A., Rector F. C., Jr, Seldin D. W. Measurement of intrarenal blood flow. II. Effect of saline diuresis in the dog. Am J Physiol. 1971 Jun;220(6):1914–1920. doi: 10.1152/ajplegacy.1971.220.6.1914. [DOI] [PubMed] [Google Scholar]
  9. DOBSON E. L., WARNER G. F. Measurement of regional sodium turnover rates and their application to the estimation of regional blood flow. Am J Physiol. 1957 May;189(2):269–276. doi: 10.1152/ajplegacy.1957.189.2.269. [DOI] [PubMed] [Google Scholar]
  10. Davis J. M., Schnermann J. The effect of antidiuretic hormone on the distribution of nephron filtration rates in rats with hereditary diabetes insipidus. Pflugers Arch. 1971;330(4):323–334. doi: 10.1007/BF00588584. [DOI] [PubMed] [Google Scholar]
  11. Domenech R. J., Hoffman J. I., Noble M. I., Saunders K. B., Henson J. R., Subijanto S. Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res. 1969 Nov;25(5):581–596. doi: 10.1161/01.res.25.5.581. [DOI] [PubMed] [Google Scholar]
  12. Ericsson B. F. Effect of vasopressin on the distribution of cardiac output and organ blood flow in the anesthetized dog. Acta Chir Scand. 1971;137(8):729–738. [PubMed] [Google Scholar]
  13. Fichman M. P., Michelakis A. M., Horton R. Regulation of aldosterone in the syndrome of inappropriate antidiuretic hormone secretion (SIADH). J Clin Endocrinol Metab. 1974 Jul;39(1):136–144. doi: 10.1210/jcem-39-1-136. [DOI] [PubMed] [Google Scholar]
  14. Fisher R. D., Grünfeld J. P., Barger A. C. Intrarenal distribution of blood flow in diabetes insipidus: role of ADH. Am J Physiol. 1970 Nov;219(5):1348–1358. doi: 10.1152/ajplegacy.1970.219.5.1348. [DOI] [PubMed] [Google Scholar]
  15. Fourman J., Kennedy G. C. An effect of antidiuretic hormone on the flow of blood through the vasa recta of the rat kidney. J Endocrinol. 1966 Jun;35(2):173–176. doi: 10.1677/joe.0.0350173. [DOI] [PubMed] [Google Scholar]
  16. HARE R. S. Endogenous creatinine in serum and urine. Proc Soc Exp Biol Med. 1950 May;74(1):148–151. doi: 10.3181/00379727-74-17837. [DOI] [PubMed] [Google Scholar]
  17. Hai M. A., Thomas S. The time-course of changes in renal tissue composition during lysine vasopressin infusion in the rat. Pflugers Arch. 1969;310(4):297–317. doi: 10.1007/BF00587241. [DOI] [PubMed] [Google Scholar]
  18. Hollenberg N. K., Epstein M., Guttmann R. D., Conroy M., Basch R. I., Merrill J. P. Effect of sodium balance on intrarenal distribution of blood flow in normal man. J Appl Physiol. 1970 Mar;28(3):312–317. doi: 10.1152/jappl.1970.28.3.312. [DOI] [PubMed] [Google Scholar]
  19. Horster M., Thurau K. Micropuncture studies on the filtration rate of single superficial and juxtamedullary glomeruli in the rat kidney. Pflugers Arch Gesamte Physiol Menschen Tiere. 1968;301(2):162–181. doi: 10.1007/BF00362733. [DOI] [PubMed] [Google Scholar]
  20. Humphreys M. H., Friedler R. M., Earley L. E. Natrriuresis produced by vasopressin or hemorrhage during water diuresis in the dog. Am J Physiol. 1970 Sep;219(3):658–665. doi: 10.1152/ajplegacy.1970.219.3.658. [DOI] [PubMed] [Google Scholar]
  21. Jamison R. L., Buerkert J., Lacy F. A micropuncture study of collecting tubule function in rats with hereditary diabetes insipidus. J Clin Invest. 1971 Nov;50(11):2444–2452. doi: 10.1172/JCI106743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. LEAF A., BARTTER F. C., SANTOS R. F., WRONG O. Evidence in man that urinary electrolyte loss induced by pitressin is a function of water retention. J Clin Invest. 1953 Sep;32(9):868–878. doi: 10.1172/JCI102805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Landwehr D. M., Klose R. M., Giebisch G. Renal tubular sodium and water reabsorption in the isotonic sodium chloride-loaded rat. Am J Physiol. 1967 Jun;212(6):1327–1333. doi: 10.1152/ajplegacy.1967.212.6.1327. [DOI] [PubMed] [Google Scholar]
  24. Lauson H. D. Metabolism of antidiuretic hormones. Am J Med. 1967 May;42(5):713–744. doi: 10.1016/0002-9343(67)90091-5. [DOI] [PubMed] [Google Scholar]
  25. MORAN W. H., Jr, MILTENBERGER F. W., SHUAYB W. A., ZIMMERMANN B. THE RELATIONSHIP OF ANTIDIURETIC HORMONE SECRETION TO SURGICAL STRESS. Surgery. 1964 Jul;56:99–108. [PubMed] [Google Scholar]
  26. McNay J. L., Abe Y. Pressure-dependent heterogeneity of renal cortical blood flow in dogs. Circ Res. 1970 Oct;27(4):571–587. doi: 10.1161/01.res.27.4.571. [DOI] [PubMed] [Google Scholar]
  27. Migdal S., Alexander E. A., Bruns F. J., Riley A. L., Levinsky N. G. Effect of hemodilution on the distribution of renal blood flow. Circ Res. 1975 Jan;36(1):71–75. doi: 10.1161/01.res.36.1.71. [DOI] [PubMed] [Google Scholar]
  28. Mowat P., Lupu A. N., Maxwell M. H. Limitations of 133 Xe washout technique in estimation of renal blood flow. Am J Physiol. 1972 Sep;223(3):682–688. doi: 10.1152/ajplegacy.1972.223.3.682. [DOI] [PubMed] [Google Scholar]
  29. Nakano J. Studies on the cardiovascular effects of synthetic vasopressin. J Pharmacol Exp Ther. 1967 Jul;157(1):19–31. [PubMed] [Google Scholar]
  30. PERLMUTT J. H. Influence of hydration on renal function and medullary sodium during vasopressin infusion. Am J Physiol. 1962 Jun;202:1098–1104. doi: 10.1152/ajplegacy.1962.202.6.1098. [DOI] [PubMed] [Google Scholar]
  31. Persson A. E., Schnermann J., Ulfendahl H. R., Wolgast M., Wunderlich P. The effect of water diuresis and antidiuretic hormone on the regional renal red cell flow. Acta Physiol Scand. 1974 Jan;90(1):193–201. doi: 10.1111/j.1748-1716.1974.tb05577.x. [DOI] [PubMed] [Google Scholar]
  32. Schmid P. G., Abboud F. M., Wendling M. G., Ramberg E. S., Mark A. L., Heistad D. D., Eckstein J. W. Regional vascular effects of vasopressin: plasma levels and circulatory responses. Am J Physiol. 1974 Nov;227(5):998–1004. doi: 10.1152/ajplegacy.1974.227.5.998. [DOI] [PubMed] [Google Scholar]
  33. Schnermann J., Valtin H., Thurau K., Nagel W., Horster M., Fischbach H., Wahl M., Liebau G. Micropuncture studies on the influence of antidiuretic hormone on tubular fluid reabsorption in rats with hereditary diabetes insipidus. Pflugers Arch. 1969;306(2):103–118. doi: 10.1007/BF00586878. [DOI] [PubMed] [Google Scholar]
  34. Stein J. H., Osgood R. W., Ferris T. F. Effect of volume expansion on distribution of glomerular filtrate and renal cortical blood flow in the dog. Am J Physiol. 1972 Oct;223(4):984–990. doi: 10.1152/ajplegacy.1972.223.4.984. [DOI] [PubMed] [Google Scholar]
  35. THORBURN G. D., KOPALD H. H., HERD J. A., HOLLENBERG M., O'MORCHOE C. C., BARGER A. C. INTRARENAL DISTRIBUTION OF NUTRIENT BLOOD FLOW DETERMINED WITH KRYPTON 85 IN THE UNANESTHETIZED DOG. Circ Res. 1963 Oct;13:290–307. doi: 10.1161/01.res.13.4.290. [DOI] [PubMed] [Google Scholar]
  36. Ukai M., Moran W. H., Jr, Zimmermann B. The role of visceral afferent pathways on vasopressin secretion and urinary exeretory patterns during surgical stress. Ann Surg. 1968 Jul;168(1):16–28. doi: 10.1097/00000658-196807000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES