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. 2000 Sep;74(2):229–243. doi: 10.1901/jeab.2000.74-229

The effects of morphine on fixed-interval patterning and temporal discrimination.

A L Odum 1, D W Schaal 1
PMCID: PMC1284793  PMID: 11029024

Abstract

Changes produced by drugs in response patterns under fixed-interval schedules of reinforcement have been interpreted to result from changes in temporal discrimination. To examine this possibility, this experiment determined the effects of morphine on the response patterning of 4 pigeons during a fixed-interval 1-min schedule of food delivery with interpolated temporal discrimination trials. Twenty of the 50 total intervals were interrupted by choice trials. Pecks to one key color produced food if the interval was interrupted after a short time (after 2 or 4.64 s). Pecks to another key color produced food if the interval was interrupted after a long time (after 24.99 or 58 s). Morphine (1.0 to 10.0 mg/kg) decreased the index of curvature (a measure of response patterning) during fixed intervals and accuracy during temporal discrimination trials. Accuracy was equally disrupted following short and long sample durations. Although morphine disrupted temporal discrimination in the context of a fixed-interval schedule, these effects are inconsistent with interpretations of the disruption of response patterning as a selective overestimation of elapsed time. The effects of morphine may be related to the effects of more conventional external stimuli on response patterning.

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Selected References

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  1. Azrin N. H. Some Effects of Noise on Human Behavior. J Exp Anal Behav. 1958 Apr;1(2):183–200. doi: 10.1901/jeab.1958.1-183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Branch M. N., Gollub L. R. A detailed analysis of the effects of d-amphetamine on behavior under fixed-interval schedules. J Exp Anal Behav. 1974 May;21(3):519–539. doi: 10.1901/jeab.1974.21-519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Branch M. N. Rate dependency, behavioral mechanisms, and behavioral pharmacology. J Exp Anal Behav. 1984 Nov;42(3):511–522. doi: 10.1901/jeab.1984.42-511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown P. L., Jenkins H. M. Auto-shaping of the pigeon's key-peck. J Exp Anal Behav. 1968 Jan;11(1):1–8. doi: 10.1901/jeab.1968.11-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FRY W., KELLEHER R. T., COOK L. A mathematical index of performance on fixed-interval schedules of reinforcement. J Exp Anal Behav. 1960 Jul;3:193–199. doi: 10.1901/jeab.1960.3-193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gentry G. D., Weiss B., Laties V. G. The microanalysis of fixed-interval responding. J Exp Anal Behav. 1983 Mar;39(2):327–343. doi: 10.1901/jeab.1983.39-327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heifetz S. A., McMillan D. E. Development of behavioral tolerance to morphine and methadone using the schedule-controlled behavior of the pigeon. Psychopharmacologia. 1971;19(1):40–52. doi: 10.1007/BF00403701. [DOI] [PubMed] [Google Scholar]
  8. Howell L. L., Byrd L. D., Marr M. J. Similarities in the rate-altering effects of white noise and cocaine. J Exp Anal Behav. 1986 Nov;46(3):381–394. doi: 10.1901/jeab.1986.46-381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Katz J. L., Goldberg S. R. Effects of ethylketazocine and morphine on schedule-controlled behavior in pigeons and squirrel monkeys. J Pharmacol Exp Ther. 1986 Nov;239(2):433–441. [PubMed] [Google Scholar]
  10. Kelleher R. T., Morse W. H. Determinants of the specificity of behavioral effects of drugs. Ergeb Physiol. 1968;60:1–56. doi: 10.1007/BFb0107250. [DOI] [PubMed] [Google Scholar]
  11. Killeen P. R., Fetterman J. G. A behavioral theory of timing. Psychol Rev. 1988 Apr;95(2):274–295. doi: 10.1037/0033-295x.95.2.274. [DOI] [PubMed] [Google Scholar]
  12. Lattal K. A., Bryan A. J. Effects of concurrent response-independent reinforcement on fixed-interval schedule performance. J Exp Anal Behav. 1976 Nov;26(3):495–504. doi: 10.1901/jeab.1976.26-495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Maricq A. V., Roberts S., Church R. M. Methamphetamine and time estimation. J Exp Psychol Anim Behav Process. 1981 Jan;7(1):18–30. doi: 10.1037//0097-7403.7.1.18. [DOI] [PubMed] [Google Scholar]
  14. McAuley F., Leslie J. C. Molecular analyses of the effects of d-amphetamine on fixed-interval schedule performances of rats. J Exp Anal Behav. 1986 Mar;45(2):207–219. doi: 10.1901/jeab.1986.45-207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McKearney J. W. Effects of d-amphetamine, morphine and chlorpromazine on responding under fixed-interval schedules of food presentation or electric shock presentation. J Pharmacol Exp Ther. 1974 Jul;190(1):141–153. [PubMed] [Google Scholar]
  16. McKim W. A. The effects of scopolamine on fixed-interval behaviour in the rat: a rate-dependency effect. Psychopharmacologia. 1973 Sep 28;32(3):255–264. doi: 10.1007/BF00422147. [DOI] [PubMed] [Google Scholar]
  17. McMillan D. E. Effects of chemicals on delayed matching behavior in pigeons I: acute effects of drugs. Neurotoxicology. 1981 Nov;2(3):485–498. [PubMed] [Google Scholar]
  18. Meck W. H. Neuropharmacology of timing and time perception. Brain Res Cogn Brain Res. 1996 Jun;3(3-4):227–242. doi: 10.1016/0926-6410(96)00009-2. [DOI] [PubMed] [Google Scholar]
  19. Odum A. L., Haworth S. C., Schaal D. W. Food-deprivation level alters the effects of morphine on pigeons' key pecking. J Exp Anal Behav. 1998 May;69(3):295–310. doi: 10.1901/jeab.1998.69-295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Odum A. L., Schaal D. W. The effects of morphine on clocked fixed-interval performance: stimulus function or strength of stimulus control? Behav Pharmacol. 1999 May;10(3):243–255. doi: 10.1097/00008877-199905000-00002. [DOI] [PubMed] [Google Scholar]
  21. Picker M., Massie C. A., Dykstra L. A. Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons. Psychopharmacology (Berl) 1987;93(2):230–236. doi: 10.1007/BF00179940. [DOI] [PubMed] [Google Scholar]
  22. Sanger D. J., Blackman D. E. Rate-dependent effects of drugs: a review of the literature. Pharmacol Biochem Behav. 1976 Jan;4(1):73–83. doi: 10.1016/0091-3057(76)90178-7. [DOI] [PubMed] [Google Scholar]
  23. Singh D., Wickens D. D. Disinhibition in instrumental conditioning. J Comp Physiol Psychol. 1968 Oct;66(2):557–559. doi: 10.1037/h0026359. [DOI] [PubMed] [Google Scholar]
  24. Stubbs A. The discrimination of stimulus duration by pigeons. J Exp Anal Behav. 1968 May;11(3):223–238. doi: 10.1901/jeab.1968.11-223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Stubbs D. A., Vautin S. J., Reid H. M., Delehanty D. L. Discriminative functions of schedule stimuli and memory: a combination of schedule and choice procedures. J Exp Anal Behav. 1978 Mar;29(2):167–180. doi: 10.1901/jeab.1978.29-167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wenger G. R., Hudzik T. J., Wright D. W. Titrating matching-to-sample performance in pigeons: effects of diazepam, morphine, and cholinergic agents. Pharmacol Biochem Behav. 1993 Oct;46(2):435–443. doi: 10.1016/0091-3057(93)90376-5. [DOI] [PubMed] [Google Scholar]
  27. Wenger G.R., McMillan D.E., Moore E., Williamson A.P. Disruption of temporal discrimination by drugs of abuse: I. Unmasking of a color bias. Behav Pharmacol. 1995 Jun;6(4):297–310. [PubMed] [Google Scholar]

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