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Journal of the Experimental Analysis of Behavior logoLink to Journal of the Experimental Analysis of Behavior
. 2002 Mar;77(2):157–169. doi: 10.1901/jeab.2002.77-157

Disruption of temporally organized behavior by morphine.

Todd W Knealing 1, David W Schaal 1
PMCID: PMC1284854  PMID: 11936249

Abstract

Four pigeons pecked keys in two different procedures commonly used in the study of timing, or temporal discrimination. Sessions consisted of 40 trials. During half of the trials, two keys were presented for 50 s. Left-key pecks were reinforced according to a variable-interval 67.86-s schedule during the first 25 s of the trial, and right-key pecks were not reinforced. During the second 25 s of the trial, right-key pecks were reinforced according to the same schedule, and left-key pecks were not reinforced. In the other half of the 40-trial session, the center key was presented. The majority of these trials arranged fixed-interval 2.5-s schedules. Occasionally a probe, or peak-interval, trial was presented. These trials were 100 s in duration and terminated without reinforcement. These two procedures were used to examine the effects of morphine on indexes of timing and on patterns of responding. Morphine altered behavior in a race-dependent manner in both procedures. Low baseline (saline) response rates were increased following morphine administration, and high baseline rates were either unaffected or decreased slightly. Rate-dependent effects appeared as leftward shifts in the timing index for two-key trials and decreases in the index of curvature for fixed-interval trials. Despite large changes in response rates, no consistent shift of the peak time was observed during peak-interval trials. These results are discussed primarily in terms of rate dependency; that is, rates of responding following drug administration tend to be determined in large part by rates of responding under baseline conditions.

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Selected References

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  1. Bayley P. J., Bentley G. D., Dawson G. R. The effects of selected antidepressant drugs on timing behaviour in rats. Psychopharmacology (Berl) 1998 Mar;136(2):114–122. doi: 10.1007/s002130050546. [DOI] [PubMed] [Google Scholar]
  2. Bizo L. A., White K. G. Biasing the pacemaker in the behavioral theory of timing. J Exp Anal Behav. 1995 Sep;64(2):225–235. doi: 10.1901/jeab.1995.64-225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bizo L. A., White K. G. The behavioral theory of timing: Reinforcer rate determines pacemaker rate. J Exp Anal Behav. 1994 Jan;61(1):19–33. doi: 10.1901/jeab.1994.61-19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chiang T. J., Al-Ruwaitea A. S., Mobini S., Ho M. Y., Bradshaw C. M., Szabadi E. The effect of d-amphetamine on performance on two operant timing schedules. Psychopharmacology (Berl) 2000 Jun;150(2):170–184. doi: 10.1007/s002130000422. [DOI] [PubMed] [Google Scholar]
  5. DEWS P. B. Studies on behavior. II. The effects of pentobarbital, methamphetamine and scopolamine on performances in pigeons involving discriminations. J Pharmacol Exp Ther. 1955 Dec;115(4):380–389. [PubMed] [Google Scholar]
  6. FLESHLER M., HOFFMAN H. S. A progression for generating variable-interval schedules. J Exp Anal Behav. 1962 Oct;5:529–530. doi: 10.1901/jeab.1962.5-529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FRY W., KELLEHER R. T., COOK L. A mathematical index of performance on fixed-interval schedules of reinforcement. J Exp Anal Behav. 1960 Jul;3:193–199. doi: 10.1901/jeab.1960.3-193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gibbon J., Church R. M. Comparison of variance and covariance patterns in parallel and serial theories of timing. J Exp Anal Behav. 1992 May;57(3):393–406. doi: 10.1901/jeab.1992.57-393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Heifetz S. A., McMillan D. E. Development of behavioral tolerance to morphine and methadone using the schedule-controlled behavior of the pigeon. Psychopharmacologia. 1971;19(1):40–52. doi: 10.1007/BF00403701. [DOI] [PubMed] [Google Scholar]
  10. Katz J. L. Effects of drugs on stimulus control of behavior. I. Independent assessment of effects on response rates and stimulus control. J Pharmacol Exp Ther. 1982 Dec;223(3):617–623. [PubMed] [Google Scholar]
  11. Katz J. L. Effects of drugs on stimulus control of behavior. II. Degree of stimulus control as a determinant of effect. J Pharmacol Exp Ther. 1983 Sep;226(3):756–763. [PubMed] [Google Scholar]
  12. Katz J. L., Goldberg S. R. Effects of ethylketazocine and morphine on schedule-controlled behavior in pigeons and squirrel monkeys. J Pharmacol Exp Ther. 1986 Nov;239(2):433–441. [PubMed] [Google Scholar]
  13. Kelleher R. T., Morse W. H. Determinants of the specificity of behavioral effects of drugs. Ergeb Physiol. 1968;60:1–56. doi: 10.1007/BFb0107250. [DOI] [PubMed] [Google Scholar]
  14. Kraemer P. J., Randall C. K., Dose J. M., Brown R. W. Impact of d-amphetamine on temporal estimation in pigeons tested with a production procedure. Pharmacol Biochem Behav. 1997 Oct;58(2):323–327. doi: 10.1016/s0091-3057(97)00296-7. [DOI] [PubMed] [Google Scholar]
  15. Laties V. G., Weiss B. Influence of drugs on behavior controlled by internal and external stimuli. J Pharmacol Exp Ther. 1966 Jun;152(3):388–396. [PubMed] [Google Scholar]
  16. Machado A., Guilhardi P. Shifts in the psychometric function and their implications for models of timing. J Exp Anal Behav. 2000 Jul;74(1):25–54. doi: 10.1901/jeab.2000.74-25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Maricq A. V., Roberts S., Church R. M. Methamphetamine and time estimation. J Exp Psychol Anim Behav Process. 1981 Jan;7(1):18–30. doi: 10.1037//0097-7403.7.1.18. [DOI] [PubMed] [Google Scholar]
  18. McAuley F., Leslie J. C. Molecular analyses of the effects of d-amphetamine on fixed-interval schedule performances of rats. J Exp Anal Behav. 1986 Mar;45(2):207–219. doi: 10.1901/jeab.1986.45-207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. McKearney J. W. Effects of d-amphetamine, morphine and chlorpromazine on responding under fixed-interval schedules of food presentation or electric shock presentation. J Pharmacol Exp Ther. 1974 Jul;190(1):141–153. [PubMed] [Google Scholar]
  20. Meck W. H. Selective adjustment of the speed of internal clock and memory processes. J Exp Psychol Anim Behav Process. 1983 Apr;9(2):171–201. [PubMed] [Google Scholar]
  21. Odum A. L., Haworth S. C., Schaal D. W. Food-deprivation level alters the effects of morphine on pigeons' key pecking. J Exp Anal Behav. 1998 May;69(3):295–310. doi: 10.1901/jeab.1998.69-295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Odum A. L., Schaal D. W. The effects of morphine on clocked fixed-interval performance: stimulus function or strength of stimulus control? Behav Pharmacol. 1999 May;10(3):243–255. doi: 10.1097/00008877-199905000-00002. [DOI] [PubMed] [Google Scholar]
  23. Odum A. L., Schaal D. W. The effects of morphine on fixed-interval patterning and temporal discrimination. J Exp Anal Behav. 2000 Sep;74(2):229–243. doi: 10.1901/jeab.2000.74-229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Roberts S. Isolation of an internal clock. J Exp Psychol Anim Behav Process. 1981 Jul;7(3):242–268. [PubMed] [Google Scholar]
  25. Stubbs D. A., Vautin S. J., Reid H. M., Delehanty D. L. Discriminative functions of schedule stimuli and memory: a combination of schedule and choice procedures. J Exp Anal Behav. 1978 Mar;29(2):167–180. doi: 10.1901/jeab.1978.29-167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Thompson T., Trombley J., Luke D., Lott D. Effects of morphine on behavior maintained by four simple food-reinforcement schedules. Psychopharmacologia. 1970;17(2):182–192. doi: 10.1007/BF00402708. [DOI] [PubMed] [Google Scholar]
  27. Wenger G. R., Wright D. W. Behavioral effects of cocaine and its interaction with d-amphetamine and morphine in rats. Pharmacol Biochem Behav. 1990 Mar;35(3):595–600. doi: 10.1016/0091-3057(90)90296-t. [DOI] [PubMed] [Google Scholar]

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