Skip to main content
NCBI home page
Archives of Emergency Medicine logoLink to Archives of Emergency Medicine
. 1984 Sep;1(3):135–142. doi: 10.1136/emj.1.3.135

The plasma kallikrein kinin system in severely ill and traumatised patients.

A D Cumming, C E Robertson, S S Jeffrey, J S Robson, I M Ledingham
PMCID: PMC1285216  PMID: 6570948

Abstract

Serial estimations of plasma prekallikrein in four critically ill patients in intensive care showed reduced values in each case, suggesting activation of the plasma kallikrein kinin system. In contrast, samples taken early from 15 patients attending an accident and emergency department with multiple trauma showed significantly elevated plasma prekallikrein concentrations; the significance of this observation is at present unclear.

Full text

PDF
135

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker S. P., O'Neill B., Haddon W., Jr, Long W. B. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974 Mar;14(3):187–196. [PubMed] [Google Scholar]
  2. Friberger P., Eriksson E., Gustavsson S., Claeson G. Determination of prekallikrein in plasma by means of a chromogenic tripeptide substrate for plasma kallikrein. Adv Exp Med Biol. 1979;120A:67–82. doi: 10.1007/978-1-4757-0926-1_8. [DOI] [PubMed] [Google Scholar]
  3. Kaplan A. P., Meier H. L., Mandle R. J., Jr The role of Hageman factor, prekallifrein, and high molecular weight kininogen in the generation of bradykinin and the initiation of coagulation and fibrinolysis. Monogr Allergy. 1977;12:120–130. [PubMed] [Google Scholar]
  4. Kimball H. R., Melmon M. L., Wolff S. M. Endotoxin-induced kinin production in man. Proc Soc Exp Biol Med. 1972 Mar;139(3):1078–1082. doi: 10.3181/00379727-139-36302. [DOI] [PubMed] [Google Scholar]
  5. Levinsky N. G. The renal kallikrein-kinin system. Circ Res. 1979 Apr;44(4):441–451. doi: 10.1161/01.res.44.4.441. [DOI] [PubMed] [Google Scholar]
  6. Mason J. W., Kleeberg U., Dolan P., Colman R. W. Plasma kallikrein and Hageman factor in Gram-negative bacteremia. Ann Intern Med. 1970 Oct;73(4):545–551. doi: 10.7326/0003-4819-73-4-545. [DOI] [PubMed] [Google Scholar]
  7. Mills I. H. Kallikrein, kininogen and kinins in control of blood pressure. Nephron. 1979;23(2-3):61–71. doi: 10.1159/000181611. [DOI] [PubMed] [Google Scholar]
  8. Nies A. S., Forsyth R. P., Williams H. E., Melmon K. L. Contribution of kinins to endotoxin shock in unanesthetized Rhesus monkeys. Circ Res. 1968 Feb;22(2):155–164. doi: 10.1161/01.res.22.2.155. [DOI] [PubMed] [Google Scholar]
  9. O'Donnell T. F., Jr, Clowes G. H., Jr, Talamo R. C., Colman R. W. Kinin activation in the blood of patients with sepsis. Surg Gynecol Obstet. 1976 Oct;143(4):539–545. [PubMed] [Google Scholar]
  10. Sealey J. E., Atlas S. A., Laragh J. H., Oza N. B., Ryan J. W. Human urinary kallikrein converts inactive to active renin and is a possible physiological activator of renin. Nature. 1978 Sep 14;275(5676):144–145. doi: 10.1038/275144a0. [DOI] [PubMed] [Google Scholar]
  11. Sumida S. Experimental studies on the effect of prophylactic proteinase inhibitor therapy on endotoxin shock. Adv Exp Med Biol. 1979;120B:395–401. [PubMed] [Google Scholar]
  12. WEBSTER M. E., CLARK W. R. Significance of the callicreincallidinogen-callidin system in shock. Am J Physiol. 1959 Aug;197:406–412. doi: 10.1152/ajplegacy.1959.197.2.406. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Emergency Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES