Abstract
A total of 300 patients attending an Accident and Emergency department with ophthalmic complaints needing topical antibiotic treatment were treated with fucithalmic or chloramphenicol (chloromycetin). Their compliance and the incidence of side effects were assessed. There was a 70.3% response rate to the questionnaire. Of the patients 51.3% using fucithalmic completed the 5 day course compared with 37.2% of those taking chloramphenicol. However, no patients were found to have suffered as a result of failing to complete the course. The incidence of side effects was similar in both groups.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dutro M. P. Chloramphenicol and aplastic anemia. Am J Ophthalmol. 1981 Dec;92(6):870–871. doi: 10.1016/s0002-9394(14)75650-8. [DOI] [PubMed] [Google Scholar]
- Flach A. J. Chloramphenicol and aplastic anemia. Am J Ophthalmol. 1982 May;93(5):664–666. doi: 10.1016/s0002-9394(14)77394-5. [DOI] [PubMed] [Google Scholar]
- Fraunfelder F. T., Bagby G. C., Jr, Kelly D. J. Fatal aplastic anemia following topical administration of ophthalmic chloramphenicol. Am J Ophthalmol. 1982 Mar;93(3):356–360. doi: 10.1016/0002-9394(82)90540-2. [DOI] [PubMed] [Google Scholar]
- Hansen S. Intraocular penetration of fusidic acid with topical Fucithalmic. Eur J Drug Metab Pharmacokinet. 1985 Oct-Dec;10(4):329–331. doi: 10.1007/BF03189761. [DOI] [PubMed] [Google Scholar]
- Hvidberg J. Fusidic acid in acute conjunctivitis. Single-blind, randomized comparison of fusidic acid and chloramphenicol viscous eye drops. Acta Ophthalmol (Copenh) 1987 Feb;65(1):43–47. doi: 10.1111/j.1755-3768.1987.tb08489.x. [DOI] [PubMed] [Google Scholar]
- Stevens J. D., Mission G. P. Ophthalmic use of chloramphenicol. Lancet. 1987 Dec 19;2(8573):1456–1456. doi: 10.1016/s0140-6736(87)91148-2. [DOI] [PubMed] [Google Scholar]
- van Bijsterveld O. P., Andriesse H., Nielsen B. H. Fusidic acid in tear fluid: pharmacokinetic study with fusidic acid viscous eye drops. Eur J Drug Metab Pharmacokinet. 1987 Jul-Sep;12(3):215–218. doi: 10.1007/BF03189900. [DOI] [PubMed] [Google Scholar]
