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. 1992 Mar;9(1):1–8. doi: 10.1136/emj.9.1.1

The effect of low molecular weight dextran on haemodynamics and respiratory function during endotoxin-induced shock.

J T Christenson 1, A al-Sarraf 1, R Abu-Saleh 1
PMCID: PMC1285818  PMID: 1373624

Abstract

The effects of low molecular weight dextran (LMWD) infusion, on gas exchange and haemodynamics were evaluated in sheep during endotoxin shock. The infusion of LMWD was started after signs of shock and lung injury were evident. After a stabilization period 10 micrograms kg-1 E. Coli endotoxin was infused i.v.. Endotoxin infusion resulted in an marked increase in pulmonary artery pressure (PAP) and decrease in mean arterial pressure (MAP), respiratory compliance, arterial oxygen tension (PaO2) and oxygen delivery index (DO2l). After 3 h MAP, PaO2, DO2l and compliance improved significantly in LMWD treated animals. The PAP had also decreased significantly in the LMWD-treated animals, but remained high in the controls (P less than 0.01). It was concluded that LMWD infusion improves haemodynamics and gas-exchange in sheep during endotoxin shock.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Huneidi W., Owunwanne A., Christenson J. T. The effect of low molecular weight dextran on early platelet deposition onto vascular grafts. Int Angiol. 1988 Jul-Sep;7(3):266–269. [PubMed] [Google Scholar]
  2. Al-Sarraf A. A., Christenson J. T., Owunwanne A. Early and late platelet sequestration in different organs during endotoxic shock. Res Exp Med (Berl) 1988;188(1):59–66. doi: 10.1007/BF01852095. [DOI] [PubMed] [Google Scholar]
  3. Brigham K. L., Bowers R., Haynes J. Increased sheep lung vascular permeability caused by Escherichia coli endotoxin. Circ Res. 1979 Aug;45(2):292–297. doi: 10.1161/01.res.45.2.292. [DOI] [PubMed] [Google Scholar]
  4. Brigham K. L. Metabolites of arachidonic acid in experimental lung vascular injury. Fed Proc. 1985 Jan;44(1 Pt 1):43–45. [PubMed] [Google Scholar]
  5. Brigham K. L. Role of free radicals in lung injury. Chest. 1986 Jun;89(6):859–863. doi: 10.1378/chest.89.6.859. [DOI] [PubMed] [Google Scholar]
  6. Christenson J. T., Sigurdsson G. H., Mousawi M., Owunwanne A. Use of indium-111 oxine to study the effects of terbutaline on pulmonary and hepatic platelet sequestration in endotoxin shock. Am J Physiol Imaging. 1987;2(4):186–191. [PubMed] [Google Scholar]
  7. Cooper J. A., Solano S. J., Bizios R., Kaplan J. E., Malik A. B. Pulmonary neutrophil kinetics after thrombin-induced intravascular coagulation. J Appl Physiol Respir Environ Exerc Physiol. 1984 Sep;57(3):826–832. doi: 10.1152/jappl.1984.57.3.826. [DOI] [PubMed] [Google Scholar]
  8. Demling R. H. Role of prostaglandins in acute pulmonary microvascular injury. Ann N Y Acad Sci. 1982;384:517–534. doi: 10.1111/j.1749-6632.1982.tb21397.x. [DOI] [PubMed] [Google Scholar]
  9. Demling R. H. The pathogenesis of respiratory failure after trauma and sepsis. Surg Clin North Am. 1980 Dec;60(6):1373–1390. doi: 10.1016/s0039-6109(16)42285-1. [DOI] [PubMed] [Google Scholar]
  10. Fischer P., Millen J. E., Glauser F. L. Endotoxin-induced increased alveolar capillary membrane permeability. Circ Shock. 1977;4(4):387–395. [PubMed] [Google Scholar]
  11. Gruber U. F., Bergentz S. E. The antithrombotic effect of dextran. J Surg Res. 1966 Sep;6(9):379–382. doi: 10.1016/s0022-4804(66)80080-x. [DOI] [PubMed] [Google Scholar]
  12. Gruber U. F., Messmer K. Colloids for blood volume support. Prog Surg. 1977;15:49–76. doi: 10.1159/000399580. [DOI] [PubMed] [Google Scholar]
  13. Harrison L. H., Beller J. J., Hinshaw L. B., Coalson J. J., Greenfield L. J. Effects of endotoxin on pulmonary capillary permeability, ultrastructure, and surfactant. Surg Gynecol Obstet. 1969 Oct;129(4):723–733. [PubMed] [Google Scholar]
  14. Lindberg B., Darle N. The effect of dextran 40 and blood transfusion on hepatic circulation and oxygen consumption in hemorrhagic shock. J Surg Res. 1977 Oct;23(4):264–273. doi: 10.1016/0022-4804(77)90175-5. [DOI] [PubMed] [Google Scholar]
  15. Modig J. Effectiveness of dextran 70 versus Ringer's acetate in traumatic shock and adult respiratory distress syndrome. Crit Care Med. 1986 May;14(5):454–457. doi: 10.1097/00003246-198605000-00003. [DOI] [PubMed] [Google Scholar]
  16. Moon B. C., Girotti M. J., Dawson R., Wren S. F. PMN superoxide radical production following a metabolic-endocrine simulation of trauma. Ann Surg. 1986 Mar;203(3):246–249. doi: 10.1097/00000658-198603000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Robb H. J., Margulis R. R., Jabs C. M. Role of pulmonary microembolism in the hemodynamics of endotoxin shock. Surg Gynecol Obstet. 1972 Nov;135(5):777–783. [PubMed] [Google Scholar]
  18. Sigurdsson G. H., Christenson J. T. Influence of terbutaline on endotoxin-induced lung injury. Circ Shock. 1988 Jul;25(3):153–163. [PubMed] [Google Scholar]
  19. Weigelt J. A., Norcross J. F., Borman K. R., Snyder W. H., 3rd Early steroid therapy for respiratory failure. Arch Surg. 1985 May;120(5):536–540. doi: 10.1001/archsurg.1985.01390290018003. [DOI] [PubMed] [Google Scholar]

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