Abstract
There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bown R. L., Gibson J. A., Sladen G. E., Hicks B., Dawson A. M. Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Gut. 1974 Dec;15(12):999–1004. doi: 10.1136/gut.15.12.999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Castleden W. M. Prolonged survival and decrease in intestinal tumours in dimethylhydrazine-treated rats fed a chemically defined diet. Br J Cancer. 1977 Apr;35(4):491–495. doi: 10.1038/bjc.1977.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Celik C., Mittelman A., Paolini N. S., Jr, Lewis D., Evans J. T. Effects of 1,2-symmetrical dimethylhydrazine on jejunocolic transposition in Sprague-Dawley rats. Cancer Res. 1981 Jul;41(7):2908–2911. [PubMed] [Google Scholar]
- Cleveland J. C., Cole J. W. Relationship of experimentally induced intestinal tumors to laxative ingestion. Cancer. 1969 May;23(5):1200–1203. doi: 10.1002/1097-0142(196905)23:5<1200::aid-cncr2820230528>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
- Cummings J. H., Hill M. J., Jenkins D. J., Pearson J. R., Wiggins H. S. Changes in fecal composition and colonic function due to cereal fiber. Am J Clin Nutr. 1976 Dec;29(12):1468–1473. doi: 10.1093/ajcn/29.12.1468. [DOI] [PubMed] [Google Scholar]
- Linos D., Beard C. M., O'Fallon W. M., Dockerty M. B., Beart R. W., Jr, Kurland L. T. Cholecystectomy and carcinoma of the colon. Lancet. 1981 Aug 22;2(8243):379–381. doi: 10.1016/s0140-6736(81)90829-1. [DOI] [PubMed] [Google Scholar]
- Macdonald I. A., Webb G. R., Mahony D. E. Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh-Day Adventists, control subjects, and bowel cancer patients. Am J Clin Nutr. 1978 Oct;31(10 Suppl):S233–S238. doi: 10.1093/ajcn/31.10.S233. [DOI] [PubMed] [Google Scholar]
- Malhotra S. L. Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology. J R Soc Med. 1982 Sep;75(9):709–714. doi: 10.1177/014107688207500907. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nelson R. L. Experimental colon cancer: what animal models have demonstrated about the origin of human colon cancer. Curr Surg. 1983 Nov-Dec;40(6):419–423. [PubMed] [Google Scholar]
- Pomare E. W., Heaton K. W., Low-Beer T. S., Espiner H. J. The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients. Am J Dig Dis. 1976 Jul;21(7):521–526. doi: 10.1007/BF01464757. [DOI] [PubMed] [Google Scholar]
- Thornton J. R., Heaton K. W. Do colonic bacteria contribute to cholesterol gall-stone formation? Effects of lactulose on bile. Br Med J (Clin Res Ed) 1981 Mar 28;282(6269):1018–1020. doi: 10.1136/bmj.282.6269.1018. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thornton J. R. High colonic pH promotes colorectal cancer. Lancet. 1981 May 16;1(8229):1081–1083. doi: 10.1016/s0140-6736(81)92244-3. [DOI] [PubMed] [Google Scholar]
- Ward J. M., Yamamoto R. S., Weisburger J. H. Cellulose dietary bulk and azoxymethane-induced intestinal cancer. J Natl Cancer Inst. 1973 Aug;51(2):713–715. [PubMed] [Google Scholar]
- Werner B., de Heer K., Mitschke H. Cholecystektomie und experimentell erzeugtes Dickdarmcarcinom. Langenbecks Arch Chir. 1977 Apr 22;343(4):267–274. doi: 10.1007/BF01300573. [DOI] [PubMed] [Google Scholar]