Skip to main content
NCBI home page
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1985 Oct;78(10):838–841. doi: 10.1177/014107688507801009

Iron status in hypogammaglobulinaemia.

H I Atrah
PMCID: PMC1289949  PMID: 4045886

Abstract

Iron, transferrin and ferritin were measured in serum samples from 16 patients with primary hypogammaglobulinaemia. Transferrin saturation was low in 12 patients (75%) and serum ferritin was low in 9 patients (56.25%). Both parameters were low, confirming the state of iron deficiency, in 6 patients (37.5%). These figures are highly significant (P less than 0.01) when compared with the prevalence of iron deficiency in the general population. Eight patients were maintained on intravenous immunoglobulin infusions and the rest on intramuscular immunoglobulin injections, their mean serum IgG being 4.4 g/l and 2.6 g/l respectively. There was no difference in the prevalence of iron deficiency between the two groups.

Full text

PDF
838

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baltimore R. S., Shedd D. G., Pearson H. A. Effect of iron saturation on the bacteriostasis of human serum: in vivo does not correlate with in vitro saturation. J Pediatr. 1982 Oct;101(4):519–523. doi: 10.1016/s0022-3476(82)80693-8. [DOI] [PubMed] [Google Scholar]
  2. Barclay R. The role of iron in infection. Med Lab Sci. 1985 Apr;42(2):166–177. [PubMed] [Google Scholar]
  3. Cook J. D. Clinical evaluation of iron deficiency. Semin Hematol. 1982 Jan;19(1):6–18. [PubMed] [Google Scholar]
  4. Cook J. D., Finch C. A., Smith N. J. Evaluation of the iron status of a population. Blood. 1976 Sep;48(3):449–455. [PubMed] [Google Scholar]
  5. Dolby J. M., Webster A. D., Borriello S. P., Barclay F. E., Bartholomew B. A., Hill M. J. Bacterial colonization and nitrite concentration in the achlorhydric stomachs of patients with primary hypogammaglobulinaemia or classical pernicious anaemia. Scand J Gastroenterol. 1984 Jan;19(1):105–110. [PubMed] [Google Scholar]
  6. Hermans P. E., Diaz-Buxo J. A., Stobo J. D. Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients. Am J Med. 1976 Aug;61(2):221–237. doi: 10.1016/0002-9343(76)90173-x. [DOI] [PubMed] [Google Scholar]
  7. Hughes W. S., Cerda J. J., Holtzapple P., Brooks F. P. Primary hypogammaglobulinemia and malabsorption. Ann Intern Med. 1971 Jun;74(6):903–910. doi: 10.7326/0003-4819-74-6-903. [DOI] [PubMed] [Google Scholar]
  8. Jacobs A., Miller F., Worwood M., Beamish M. R., Wardrop C. A. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. doi: 10.1136/bmj.4.5834.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kinlen L. J., Webster A. D., Bird A. G., Haile R., Peto J., Soothill J. F., Thompson R. A. Prospective study of cancer in patients with hypogammaglobulinaemia. Lancet. 1985 Feb 2;1(8423):263–266. doi: 10.1016/s0140-6736(85)91037-2. [DOI] [PubMed] [Google Scholar]
  10. Magilavy D. B., Cassidy J. T., Tubergen D. G., Petty R. E., Chrisholm R., McCall K. Intravenous gamma globulin in the management of patients with hypogammaglobulinemia. J Allergy Clin Immunol. 1978 Jun;61(6):378–383. doi: 10.1016/0091-6749(78)90117-3. [DOI] [PubMed] [Google Scholar]
  11. Nolte M. T., Pirofsky B., Gerritz G. A., Golding B. Intravenous immunoglobulin therapy for antibody deficiency. Clin Exp Immunol. 1979 May;36(2):237–243. [PMC free article] [PubMed] [Google Scholar]
  12. Peter F., Wang S. Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency. Clin Chem. 1981 Feb;27(2):276–279. [PubMed] [Google Scholar]
  13. Pollack S. Malaria and iron. Br J Haematol. 1983 Feb;53(2):181–183. doi: 10.1111/j.1365-2141.1983.tb02009.x. [DOI] [PubMed] [Google Scholar]
  14. So A., Brenner M. K., Hill I. D., Asherson G. L., Webster A. D. Intravenous gammaglobulin treatment in patients with hypogammaglobulinaemia. Br Med J (Clin Res Ed) 1984 Nov 3;289(6453):1177–1178. doi: 10.1136/bmj.289.6453.1177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stockman J. A., 3rd Infections and iron. Too much of a good thing? Am J Dis Child. 1981 Jan;135(1):18–20. doi: 10.1001/archpedi.1981.02130250006003. [DOI] [PubMed] [Google Scholar]
  16. Twomey J. J., Jordan P. H., Jr, Laughter A. H., Meuwissen H. J., Good R. A. The gastric disorder in immunoglobulin-deficient patients. Ann Intern Med. 1970 Apr;72(4):499–504. doi: 10.7326/0003-4819-72-4-499. [DOI] [PubMed] [Google Scholar]
  17. Webster A. D. The gut and immunodeficiency disorders. Clin Gastroenterol. 1976 May;5(2):323–340. [PubMed] [Google Scholar]
  18. Weinberg E. D. Iron and susceptibility to infectious disease. Science. 1974 May 31;184(4140):952–956. doi: 10.1126/science.184.4140.952. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES