Past
The study addresses the clinical question of how increasing patient age affects the utilization and outcomes of radical prostatectomy (RP) for prostate cancer. As life expectancy continues to rise in Western countries, more elderly men seek curative treatment.1 However, most previous studies were limited to single institutions and smaller cohorts, providing little insight into nationwide trends.2,3 The main scientific problem was the lack of population-based data examining whether older patients (particularly those aged ≥ 75 years) increasingly undergo RP and how age impacts perioperative outcomes such as mortality, transfusion rates, and hospital stay length.
Present
Using national hospital billing data from Germany (2006–2022; 444,102 cases), the study demonstrates a clear and continuous increase in the mean age of RP patients, with the proportion of men ≥ 75 years quadrupling from 3 to 12% over 17 years. Although older patients experienced higher in-hospital mortality (0.3% versus 0.1%), higher transfusion rates (5% versus 2%), and longer hospital stays (8.15 versus 7.57 days), these differences were statistically significant but clinically minor. Importantly, the study shows that RP, including robotic-assisted approaches, remains a feasible and safe option for well-selected elderly patients. It also highlights a shift in treatment decision-making—from rigid chronological age criteria to biological fitness and comorbidity assessment—reflecting increased flexibility in guideline adherence.4
Future
Future research should focus on functional outcomes (continence and erectile function) in elderly patients, as these aspects substantially affect quality of life but remain underexplored in national data.5 Studies should also assess whether the growing number of elderly RP patients impacts overall postoperative recovery and healthcare resource allocation. Furthermore, given the rising demand for surgical treatment among older men alongside a declining medical workforce, there is a need for strategic planning to ensure that these patients receive optimal care in high-volume, experienced centers. Future investigations integrating geriatric assessment tools and long-term oncological outcomes will be crucial for refining patient selection and treatment guidelines.
Funding
Open Access funding enabled and organized by Projekt DEAL.
Disclosure
The authors declare no conflicts of interest.
Footnotes
This article refers to: Baunacke, M et al., Increasing age at radical prostatectomy: a total population analysis in Germany from 2006 to 2022. Ann Surg Oncol. 2025. (10.1245/s10434-025-18740-5).
Publisher's Note
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References
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