Abstract
The timing of drug ingestion over 24 hours was assessed in 58 outpatients taking drugs three times daily. The mean time between 1st and 2nd dose was 5.7 hours, 2nd and 3rd 6.1 hours and between 3rd and 1st of the next day 12.2 hours. Based on a simulation of hydralazine pharmacokinetics, such irregular administration would increase peak levels by 10% and decrease trough levels by 64% compared with regular 8-hourly doses.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Harron D. W., Howe A., Shanks R. G. Slow release beta-adrenoceptor blocking drugs. J R Coll Physicians Lond. 1983 Apr;17(2):126–132. [PMC free article] [PubMed] [Google Scholar]
- Howe A. Treatment of hypertension. Comparative trial of metoprolol Durules (once daily) and metoprolol tablets (twice daily). Practitioner. 1982 Mar;226(1365):573–575. [PubMed] [Google Scholar]
- Porter A. M. Drug defaulting in a general practice. Br Med J. 1969 Jan 25;1(5638):218–222. doi: 10.1136/bmj.1.5638.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Quaterman C. P., Kendall M. J., Welling P. G. Plasma levels and negative chronotropic effect of metoprolol following single doses of a conventional and sustained-release formulation. Eur J Clin Pharmacol. 1979 Mar 26;15(2):97–103. doi: 10.1007/BF00609871. [DOI] [PubMed] [Google Scholar]
- Talseth T. Clinical pharmacokinetics of hydrallazine. Clin Pharmacokinet. 1977 Sep-Oct;2(5):317–329. doi: 10.2165/00003088-197702050-00001. [DOI] [PubMed] [Google Scholar]