Skip to main content
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1986 Jan;79(1):19–21. doi: 10.1177/014107688607900107

Atropine or glycopyrrolate with neostigmine 5 mg: a comparative dose-response study.

M G Salem, R S Ahearn
PMCID: PMC1290140  PMID: 3944815

Abstract

One hundred and fifteen patients, separated into 4 groups, received neostigmine 5 mg with either atropine 1.2 mg or 1.8 mg, or glycopyrrolate 0.6 mg or 0.9 mg. Those receiving 0.9 mg glycopyrrolate had insignificant changes in heart rate in the immediate postreversal period. It is recommended that when glycopyrrolate is used with 5 mg neostigmine, the optimum dose is 0.9 mg.

Full text

PDF
19

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baraka A., Yared J. P., Karam A. M., Winnie A. Glycopyrrolate-neostigmine and atropine-neostigmine mixtures affect postanesthetic arousal times differently. Anesth Analg. 1980 Jun;59(6):431–434. [PubMed] [Google Scholar]
  2. Blitt C. D., Moon B. J., Kartchner C. D. Duration of action of neostigmine in man. Can Anaesth Soc J. 1976 Jan;23(1):80–84. doi: 10.1007/BF03004997. [DOI] [PubMed] [Google Scholar]
  3. Bridenbaugh P. O., Churchll-Davidson H. C. Response to tubocurarine chloride and its reversal by neostigmine methylsulfate in man. JAMA. 1968 Feb 19;203(8):541–544. [PubMed] [Google Scholar]
  4. Kongsrud F., Sponheim S. A comparison of atropine and glycopyrrolate in anaesthetic practice. Acta Anaesthesiol Scand. 1982 Dec;26(6):620–625. doi: 10.1111/j.1399-6576.1982.tb01827.x. [DOI] [PubMed] [Google Scholar]
  5. Koppanyi T., Vivino A. E. PREVENTION AND TREATMENT OF d-TUBOCURARINE POISONING. Science. 1944 Nov 24;100(2604):474–475. doi: 10.1126/science.100.2604.474. [DOI] [PubMed] [Google Scholar]
  6. Mirakhur R. K., Dundee J. W., Clarke R. S. Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture. Br J Anaesth. 1977 Aug;49(8):825–829. doi: 10.1093/bja/49.8.825. [DOI] [PubMed] [Google Scholar]
  7. Mirakhur R. K., Dundee J. W. Comparison of the effects of atropine and glycopyrrolate on various end-organs. J R Soc Med. 1980 Oct;73(10):727–730. [PMC free article] [PubMed] [Google Scholar]
  8. Mirakhur R. K., Dundee J. W. Glycopyrrolate: pharmacology and clinical use. Anaesthesia. 1983 Dec;38(12):1195–1204. doi: 10.1111/j.1365-2044.1983.tb12525.x. [DOI] [PubMed] [Google Scholar]
  9. Mirakhur R. K., Dundee J. W., Jones C. J., Coppel D. L., Clarke R. S. Reversal of neuromuscular blockade: dose determination studies with atropine and glycopyrrolate given before or in a mixture with neostigmine. Anesth Analg. 1981 Aug;60(8):557–562. [PubMed] [Google Scholar]
  10. Proakis A. G., Harris G. B. Comparative penetration of glycopyrrolate and atropine across the blood--brain and placental barriers in anesthetized dogs. Anesthesiology. 1978 May;48(5):339–344. doi: 10.1097/00000542-197805000-00007. [DOI] [PubMed] [Google Scholar]
  11. Viby-Mogensen J., Jørgensen B. C., Ording H. Residual curarization in the recovery room. Anesthesiology. 1979 Jun;50(6):539–541. doi: 10.1097/00000542-197906000-00014. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES