Abstract
A study was performed to determine the morbidity and mortality from ischaemic heart disease (IHD) in patients with heterozygous familial hypercholesterolaemia (FH) and severe hypertriglyceridaemia (pretreatment plasma triglyceride greater than 5 mmol/l). Twenty-nine (38%) of 76 patients with FH and 8(44%) of 18 patients with hypertriglyceridaemia had evidence of IHD. Over a mean follow-up period of 5.5 years, 2 patients with hypertriglyceridaemia died but there were no deaths in patients with FH. This contrasts with earlier reports which showed a high mortality in FH patients. The lower mortality may be due to improved treatment and consequent lower levels of cholesterol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burstein M., Scholnick H. R., Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970 Nov;11(6):583–595. [PubMed] [Google Scholar]
- Heiberg A. The risk of atherosclerotic vascular disease in subjects with xanthomatosis. Acta Med Scand. 1975 Oct;198(4):249–261. doi: 10.1111/j.0954-6820.1975.tb19536.x. [DOI] [PubMed] [Google Scholar]
- Hjermann I., Velve Byre K., Holme I., Leren P. Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men. Lancet. 1981 Dec 12;2(8259):1303–1310. doi: 10.1016/s0140-6736(81)91338-6. [DOI] [PubMed] [Google Scholar]
- Jensen J., Blankenhorn D. H., Kornerup V. Coronary disease in familial hypercholesterolemia. Circulation. 1967 Jul;36(1):77–82. doi: 10.1161/01.cir.36.1.77. [DOI] [PubMed] [Google Scholar]
- Kannel W. B., Castelli W. P., Gordon T., McNamara P. M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med. 1971 Jan;74(1):1–12. doi: 10.7326/0003-4819-74-1-1. [DOI] [PubMed] [Google Scholar]
- Keys A., Aravanis C., Blackburn H., Van Buchem F. S., Buzina R., Djordjevic B. S., Fidanza F., Karvonen M. J., Menotti A., Puddu V. Probability of middle-aged men developing coronary heart disease in five years. Circulation. 1972 Apr;45(4):815–828. doi: 10.1161/01.cir.45.4.815. [DOI] [PubMed] [Google Scholar]
- Onongbu I. C., Lewis B. Lipoprotein fractionation by a precipitation method. A simple quantitative procedure. Clin Chim Acta. 1976 Sep 20;71(3):397–402. doi: 10.1016/0009-8981(76)90090-5. [DOI] [PubMed] [Google Scholar]
- Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet. 1969 Dec 27;2(7635):1380–1382. doi: 10.1016/s0140-6736(69)90930-1. [DOI] [PubMed] [Google Scholar]