Abstract
Gross metal poisoning as a causative factor in mental handicap is now relatively rare although historically it was important. Currently attention is being focused on the importance of chronic metal poisoning, there being much debate on, for instance, the possible effects of low levels of lead on intelligence in childhood. This paper examines the levels of a number of metals, both toxic and essential, in two groups of agitated patients in a long-stay psychiatric hospital in the UK. The two groups examined comprise 'hyperactive' mentally handicapped children and senile dementia patients, all of whom showed moderate to severe agitation. Blood and hair tissue were used to assess the body status of a number of metals and the results were compared with controls matched as closely as possible and from a similar hospital environment. The most significant findings are the raised levels of aluminium in the agitated senile dementia patients and the low levels of zinc and raised levels of lead in the hyperactive children.
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Selected References
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- Chittleborough G. A chemist's view of the analysis of human hair for trace elements. Sci Total Environ. 1980 Jan;14(1):53–75. doi: 10.1016/0048-9697(80)90126-6. [DOI] [PubMed] [Google Scholar]
- Crapper D. R., Krishnan S. S., Dalton A. J. Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration. Science. 1973 May 4;180(4085):511–513. doi: 10.1126/science.180.4085.511. [DOI] [PubMed] [Google Scholar]
- Gibson R. S. Hair as a biopsy material for the assessment of trace element status in infancy. A review. J Hum Nutr. 1980 Dec;34(6):405–416. [PubMed] [Google Scholar]
- Howard J. M. Clinical import of small increases in serum aluminum. Clin Chem. 1984 Oct;30(10):1722–1723. [PubMed] [Google Scholar]
- Laker M. On determining trace element levels in man: the uses of blood and hair. Lancet. 1982 Jul 31;2(8292):260–262. doi: 10.1016/s0140-6736(82)90336-1. [DOI] [PubMed] [Google Scholar]
- Maugh T. H., 2nd Hair: a diagnostic tool to complement blood serum and urine. Science. 1978 Dec 22;202(4374):1271–1273. doi: 10.1126/science.725602. [DOI] [PubMed] [Google Scholar]
- Needleman H. L., Gunnoe C., Leviton A., Reed R., Peresie H., Maher C., Barrett P. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med. 1979 Mar 29;300(13):689–695. doi: 10.1056/NEJM197903293001301. [DOI] [PubMed] [Google Scholar]