Abstract
Three out of 41 patients treated with azathioprine and low-dose corticosteroids from 1976 to 1983 developed non-Hodgkin's lymphoma. This strikingly high incidence of lymphoma may be a reflection of long-term use of azathioprine.
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- Barnes C. G., Turnbull A. L., Vernon-Roberts B. Felty's syndrome. A clinical and pathological survey of 21 patients and their response to treatment. Ann Rheum Dis. 1971 Jul;30(4):359–374. doi: 10.1136/ard.30.4.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunter T., Urowitz M. B., Gordon D. A., Smythe H. A., Ogryzlo M. A. Azathioprine in rheumatoid arthritis: a long-term follow-up study. Arthritis Rheum. 1975 Jan-Feb;18(1):15–20. doi: 10.1002/art.1780180103. [DOI] [PubMed] [Google Scholar]
- Isomäki H. A., Hakulinen T., Joutsenlahti U. Excess risk of lymphomas, leukemia and myeloma in patients with rheumatoid arthritis. J Chronic Dis. 1978;31(11):691–696. doi: 10.1016/0021-9681(78)90071-1. [DOI] [PubMed] [Google Scholar]
- Jack A. S., Boyce B. F., Lee F. D. Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. J Clin Pathol. 1986 Jan;39(1):16–21. doi: 10.1136/jcp.39.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis P., Hazleman B. L., Hanka R., Roberts S. Cause of death in patients with rheumatoid arthritis with particular reference to azathioprine. Ann Rheum Dis. 1980 Oct;39(5):457–461. doi: 10.1136/ard.39.5.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prior P., Symmons D. P., Hawkins C. F., Scott D. L., Brown R. Cancer morbidity in rheumatoid arthritis. Ann Rheum Dis. 1984 Apr;43(2):128–131. doi: 10.1136/ard.43.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Speerstra F., Boerbooms A. M., van de Putte L. B., van Beusekom H. J., Kruijsen M. W., Vandenbroucke J. P. Side-effects of azathioprine treatment in rheumatoid arthritis: analysis of 10 years of experience. Ann Rheum Dis. 1982;41 (Suppl 1):37–39. doi: 10.1136/ard.41.suppl_1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Symington G. R., Mackay I. R., Lambert R. P. Cancer and teratogenesis: infrequent occurrence after medical use of immunosuppressive drugs. Aust N Z J Med. 1977 Aug;7(4):368–372. doi: 10.1111/j.1445-5994.1977.tb04397.x. [DOI] [PubMed] [Google Scholar]
- Whisnant J. K., Pelkey J. Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. Ann Rheum Dis. 1982;41 (Suppl 1):44–47. doi: 10.1136/ard.41.suppl_1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zulman J., Jaffe R., Talal N. Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm. N Engl J Med. 1978 Nov 30;299(22):1215–1220. doi: 10.1056/NEJM197811302992204. [DOI] [PubMed] [Google Scholar]