Abstract
The addition of protamine, of both human and animal origin, to cultures of epithelial and fibroblastic cells has demonstrated that this component of sperm proteins may be capable of bringing about neoplastic transformation in vitro.
Full text
PDF



Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AMOS H., KEARNS K. E. INFLUENCE OF BACTERIAL RIBONUCLEIC ACID ON ANIMAL CELLS IN CULTURE. II. PROTAMINE ENHANCEMENT OF RNA UPTAKE. Exp Cell Res. 1963 Oct;32:14–25. doi: 10.1016/0014-4827(63)90064-8. [DOI] [PubMed] [Google Scholar]
- BECKER F. F., GREEN H. The effects of protamines and histones on the nucleic acids of ascites tumor cells. Exp Cell Res. 1960 Mar;19:361–375. doi: 10.1016/0014-4827(60)90014-8. [DOI] [PubMed] [Google Scholar]
- Cooper H. S., Patchefsky A. S., Marks G. Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. Dis Colon Rectum. 1979 Nov-Dec;22(8):557–558. doi: 10.1007/BF02587005. [DOI] [PubMed] [Google Scholar]
- FELIX K., FISCHER H., KREKELS A. Protamines and nucleoprotamines. Prog Biophys Biophys Chem. 1956;6:1–23. [PubMed] [Google Scholar]
- French P. Ethanol extraction of basic proteins from ejaculated human spermatozoa. Aust J Biol Sci. 1979 Oct;32(4-5):443–449. doi: 10.1071/bi9790443. [DOI] [PubMed] [Google Scholar]
- Latner A. L., Longstaff E., Lunn J. M. Invasive properties of histone transformed cells. Br J Cancer. 1971 Sep;25(3):568–573. doi: 10.1038/bjc.1971.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Latner A. L., Longstaff E. Modification by crude histones of gene activity for lactate dehydrogenase. Nature. 1969 Oct 4;224(5214):71–73. doi: 10.1038/224071a0. [DOI] [PubMed] [Google Scholar]
- Latner A. L., Longstaff E., Turner G. A. Enhanced malignant behaviour of cells treated with crude rat liver histone. Br J Cancer. 1973 Mar;27(3):218–229. doi: 10.1038/bjc.1973.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levine A. S., Nesbit M. E., White J. G., Yarbro J. W. Effects of fractionated histones on nucleic acid synthesis in 6C3HED mouse ascites tumor cells and in normal spleen cells. Cancer Res. 1968 May;28(5):831–844. [PubMed] [Google Scholar]
- Phillips R. K., Quill D. S., Dudley H. A. Experimental colon neoplasia enhanced by extract of sperm (protamine). J R Soc Med. 1984 Oct;77(10):830–832. doi: 10.1177/014107688407701005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reid B. L., French P. W., Singer A., Hagan B. E., Coppleson M. Sperm basic proteins in cervical carcinogenesis: Correlation with socioeconomic class. Lancet. 1978 Jul 8;2(8080):60–62. doi: 10.1016/s0140-6736(78)91378-8. [DOI] [PubMed] [Google Scholar]
- Ryser H. J., Hancock R. Histones and basic polyamino acids stimulate the uptake of albumin by tumor cells in culture. Science. 1965 Oct 22;150(3695):501–503. doi: 10.1126/science.150.3695.501. [DOI] [PubMed] [Google Scholar]
- Singer A., Reid B. L., Coppleson M. A hypothesis: the role of a high-risk male in the etiology of cervical carcinoma: a correlation of epidemiology and molecular biology. Am J Obstet Gynecol. 1976 Sep 1;126(1):110–115. doi: 10.1016/0002-9378(76)90474-9. [DOI] [PubMed] [Google Scholar]
- Wang E., Goldberg A. R. Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4065–4069. doi: 10.1073/pnas.73.11.4065. [DOI] [PMC free article] [PubMed] [Google Scholar]





