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. 2026 Feb 17;15(2):e70155. doi: 10.1002/open.70155

Front Cover: Ruthenium‐Catalyzed C—H Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study (ChemistryOpen 2/2026)

Esther R S Paz 1, Cauê P Souza 2, Joyce C De Oliveira 1, Renata G Almeida 1, Chonny Herrera‐Acevedo 3, Sulaiman Lakoh 4, Guilherme A M Jardim 1,, Eufrânio N da Silva Júnior 1,, Felipe Fantuzzi 2,
PMCID: PMC12910514

Abstract

The Front Cover image highlights a computational study of the Ru(II)‐catalyzed C–H alkenylation of menadione with ethenesulfonyl fluoride, enabling SuFEx functionalization of quinones. Density functional benchmarking against DLPNO‐CCSD(T) establishes a robust mechanistic picture and supports the rational design of naphthoquinone derivatives targeting Trypanosoma cruzi. More details are available in the Research Article by Felipe Fantuzzi and co‐workers (DOI: 10.1002/open.202500465).

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